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Table 4. Genetic and related effects of fumonisin B1
Test system
Result a
Without
exogenous
metabolic
system
With
exogenous
metabolic
system
Dose
(LED or HID) b
Reference
SOS repair, Escherichia coli PQ37 – – 500 μg/plate Knasmüller et al. (1997)
Escherichia coli rec strains, differential toxicity – – 500 μg/plate Knasmüller et al. (1997)
Salmonella typhimurium TA100, TA102, TA97a, TA98, reverse mutation – – 5000 μg/plate c
Gelderblom & Snyman
(1991)
Salmonella typhimurium TA100, reverse mutation – – 100 μg/plate Park et al. (1992)
Salmonella typhimurium TA100, TA98, reverse mutation – – 500 μg/plate Knasmüller et al. (1997)
Salmonella typhimurium TA100, TA102, TA98, reverse mutation – – 114 μg/plate Aranda et al. (2000)
Salmonella typhimurium TA100, TA102, TA1535, TA1537, TA98, reverse
mutation
NT – d
200 μg/plate Ehrlich et al. (2002)
Luminescence induction, Vibrio fischeri, mutation in vitro + NT 5 Sun and Stahr (1993)
DNA strand breaks (DNA-unwinding method), rat liver cells in vitro + NT 29 Sahu et al. (1998)
DNA strand breaks (Comet assay), C6 rat brain glioma cells in vitro + NT 2.2 Mobio et al. (2000a)
DNA adduct formation, oligonucleotides in vitro e
– NT 360 Pocsfalvi et al. (2000)
Unscheduled DNA synthesis, rat primary hepatocytes, in vitro – NT 58 Gelderblom et al.
(1992b)
Unscheduled DNA synthesis, rat primary hepatocytes, in vitro – NT 180 Norred et al. (1992)
DNA hypermethylation, C6 rat brain glioma cells, in vitro + NT 6.5 Mobio et al. (2000b)
Micronucleus formation, rat hepatocytes in vitro – NT 100 Knasmüller et al. (1997)
Chromosomal aberrations, rat hepatocytes in vitro + NT 1 Knasmüller et al. (1997)
Cell transformation, BALB/3T3 A31-1-1 mouse embryo cells – NT 1000 Sheu et al. (1996)
DNA damage (Comet assay), human hepatoma (HepG2) cells in vitro + NT 25 Ehrlich et al. (2002)
DNA damage (Comet assay), human fibroblasts in vitro + NT 7.2 Galvano et al. (2002)
Micronucleus formation, human hepatoma (HepG2) cells in vitro + NT 25 Ehrlich et al. (2002)
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