IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC ...

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ANNEX 299 Pitt, J.I. & Miscamble, B.F. (1995) Water relations of Aspergillus flavus and closely related species. J. Food Prot., 58, 86–90 Pitt, J.I., Dyer, S.K. & McCammon, S. (1991) Systemic invasion of developing peanut plants by Aspergillus flavus. Lett. appl. Microbiol., 13, 16–20 Pitt, J.I., Hocking, A.D., Bhudhasamai, K., Miscamble, B.F., Wheeler, K.A. & Tanboon-Ek, P. (1993) The normal mycoflora of commodities from Thailand. 1. Nuts and oilseeds. Int. J. Food Microbiol., 20, 211–226 Pitt, J.I., Hocking, A.D., Bhudhasamai, K., Miscamble, B.F., Wheeler, K.A. & Tanboon-Ek, P. (1994) The normal mycoflora of commodities from Thailand. 2. Beans, rice, small grains and other commodities. Int. J. Food Microbiol., 23, 35–53 Pitt, J.I., Hocking, A.D., Miscamble, B.F., Dharmaputra, O.S., Kuswanto, K.R., Rahayu, E.S. & Sardjono, T. (1998) The mycoflora of food commodities from Indonesia. J. Food Mycol., 1, 41–60 Pohland, A.E. & Wood, G.E. (1987) Occurrence of mycotoxins in food. In: Krogh, P., ed., Mycotoxins in Food, London, Academic Press, pp. 35– 64 Prevot, A. (1986) Commercial detoxification of aflatoxin-contaminated peanut meal. Bioact. Mol., 1, 341–351 Price, R.L., Lough, O.G. & Brown, W.H. (1982) Ammoniation of whole cottonseed at atmospheric pressure and ambient temperature to reduce aflatoxin M 1 in milk. J. Food Prot., 45, 341–344 Rachaputi, N. (1999) Pre-harvest management trials. In: Proceedings of the Aflatoxin Research Update Workshop, Kingaroy, Queensland, 25th August, 1999, Kingaroy, Qld, Queensland Department of Primary Industries Read, M. (1989) Removal of aflatoxin contamination from the Australian groundnut crop. In: Aflatoxin Contamination of Groundnut: Proceedings of the International Workshop, 6-9 October, 1987, ICRISAT Center, India, Patancheru, ICRISAT (International Crops Institute for the Semi-Arid Tropics), pp. 133–140 Sanders, T.H., Hill, R.A., Cole, R.H. & Blankenship, P.D. (1981) Effect of drought on occurrence of Aspergillus flavus in maturing peanuts. J. Am. Oil Chem. Soc., 58, 966A–970A Sanders, T.H., Blankenship, P.D., Cole, R.J. & Hill, R.A. (1984) Effect of soil temperature and drought on peanut pod and stem temperatures relative to Aspergillus flavus invasion and aflatoxin contamination. Mycopathologia, 86, 51–54 Sanders, T.H., Cole, R.J., Blankenship, P.D. & Hill, R.A. (1985) Relation of environmental stress duration to Aspergillus flavus invasion and aflatoxin production in preharvest peanuts. Peanut Sci., 12, 90–93 Sauer, D.B., Storey, C.L. & Walker, D.E. (1984) Fungal populations in US farm-stored grain and their relationship to moisture, storage time, regions and insect infestation. Phytopathology, 74, 1050–1053 Schroeder, H.W. & Boller, R.A. (1973) Aflatoxin production of species and strains of the Aspergillus flavus group isolated from field crops. Appl. Microbiol., 25, 885–889 Schroder, H.W., Boller, R.A. & Hein, H., Jr (1968) Reduction in aflatoxin contamination of rice by milling procedures. Cereal Chem., 45, 574–580 Scott, P.M. (1984) Effects of food processing on mycotoxins. J. Food Prot., 47, 489–499
300 IARC MONOGRAPHS VOLUME 82 Sharman, M., Patey, A.L., Bloomfield, D.A. & Gilbert, J. (1991) Surveillance and control of aflatoxin contamination of dried figs and fig paste imported into the United Kingdom. Food Addit. Contam., 8, 299–304 Shotwell, O.L. (1983) Aflatoxin detection and determination in corn. In: Diener, U.L., Asquith, R.L. & Dickens, J.W., eds, Aflatoxin and Aspergillus flavus in Corn (Southern Cooperative Series Bulletin 279), Opelika, AL, Craftmaster Printers, pp. 38–45 Shotwell, O.L., Goulden, M.L. & Hesseltine, C.W. (1972) Aflatoxin contamination: Association with foreign material and characteristic fluorescence in damaged corn kernels. Cereal Chem., 49, 458–465 Simpson, M.E. & Batra, L.R. (1984) Ecological relations in respect to a boll rot of cotton caused by Aspergillus flavus. In: Kurata, H. & Ueno, Y., eds, Toxigenic Fungi — Their Toxins and Health Hazard (Developments in Food Science 7), Amsterdam, Elsevier, pp. 24–32 Steiner, W.E., Rieker, R.H. & Battaglia, R. (1988) Aflatoxin contamination in dried figs: Distribution and association with fluorescence. J. agric. Food Chem., 36, 88–91 Stoloff, L., Trucksess, M., Anderson, P.W. & Glabe, E.F. (1978) Determination of the potential for mycotoxin contamination of pasta products. J. Food Sci., 3, 228–230 Wambugu, F. (1999) Why Africa needs agricultural biotech. Nature, 400, 15–16 Wells, T.R. & Kreutzer, W.A. (1972) Aerial invasion of peanut flower tissues by Aspergillus flavus under gnotobiotic conditions (Abstract). Phytopathology, 62, 797 Weng, C.Y., Martinez, A.J. & Park, D.L. (1994) Efficacy and permanency of ammonia treatment in reducing aflatoxin levels in corn. Food Addit. Contam., 11, 649–658 Wheeler, K.A., Hurdman, B.F. & Pitt, J.I. (1991) Influence of pH on the growth of some toxigenic species of Aspergillus, Penicillium and Fusarium. Int. J. Food Microbiol., 12, 141–150 Widstrom, N.W., McMillian, W.W. & Wilson, D. (1987) Segregation for resistance to aflatoxin contamination among seeds on an ear of hybrid maize. Crop Sci., 27, 961–963 Wood, G.M. (1982) Effects of processing on mycotoxins in maize. Chem. Ind., 18 Dec., 972–974
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WORLD HEALTH ORGANIZATION INTERNATI
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IARC MONOGRAPHS In 1969, the Intern
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iv IARC MONOGRAPHS VOLUME 82 3.2 Th
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vi IARC MONOGRAPHS VOLUME 82 SOME M
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IARC WORKING GROUP ON THE EVALUATIO
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PARTICIPANTS 5 Observer, representi
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PREAMBLE
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10 IARC MONOGRAPHS VOLUME 82 plasms
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12 IARC MONOGRAPHS VOLUME 82 collec
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14 agents present. For processes, i
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16 IARC MONOGRAPHS VOLUME 82 Finall
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18 IARC MONOGRAPHS VOLUME 82 and mi
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20 IARC MONOGRAPHS VOLUME 82 (c) St
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22 IARC MONOGRAPHS VOLUME 82 may le
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24 IARC MONOGRAPHS VOLUME 82 It is
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26 IARC MONOGRAPHS VOLUME 82 Data r
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28 when there is strong evidence th
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30 IARC MONOGRAPHS VOLUME 82 Vol. 7
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GENERAL REMARKS ON THE SUBSTANCES C
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SOME TRADITIONAL HERBAL MEDICINES
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44 which may include, for example,
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46 2. Use of Traditional Herbal Med
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48 IARC MONOGRAPHS VOLUME 82 decade
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50 IARC MONOGRAPHS VOLUME 82 Table
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52 3.2.1 Definition of herbal medic
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54 3.2.8 Individual supply Herbal m
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58 3.3.2 Germany (see Kraft, 1999;
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60 beyond placebo, and this informa
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62 3.3.5 Canada The Canadian Food a
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64 of adverse reactions to OTC drug
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66 IARC MONOGRAPHS VOLUME 82 3.3.12
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68 IARC MONOGRAPHS VOLUME 82 Jellin
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70 IARC MONOGRAPHS VOLUME 82 Simila
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72 IARC MONOGRAPHS VOLUME 82 Figure
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74 diameter of 4-6 cm or more, lobe
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76 1.2 Use 1.2.1 Aristolochia conto
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78 1.3.3 Aristolochia fangchi Compo
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80 1.6.2 Structural and molecular f
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82 chromatographic separation with
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84 may contain aristolochic acids.
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86 IARC MONOGRAPHS VOLUME 82 A bila
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88 received distilled water. The an
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90 IARC MONOGRAPHS VOLUME 82 Figure
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92 varied from undetectable (< 0.02
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94 lochic acids enhanced immune res
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96 4.4 Genetic and related effects
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Table 3 (contd) Details of study DN
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Table 4. DNA adduct formation with
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Table 4 (contd) Details of study Co
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Table 5 (contd) Species Treatment I
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Table 6. DNA adduct formation by ar
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Table 6 (contd) Test system Assay D
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Table 6 (contd) Test system Assay D
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Table 7. Polymerase action on arist
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Table 8 (contd) Test system Drosoph
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116 of the forestomach and lung of
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118 lochic acid II (three metabolit
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120 IARC MONOGRAPHS VOLUME 82 Che,
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122 IARC MONOGRAPHS VOLUME 82 Healt
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124 IARC MONOGRAPHS VOLUME 82 Nishi
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126 IARC MONOGRAPHS VOLUME 82 Schme
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128 IARC MONOGRAPHS VOLUME 82 Yang,
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130 Figure 1. Morinda officinalis H
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132 1.3.2 Morinda officinalis A num
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134 by Soxhlet extraction with ethy
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136 2.1 Case-control studies 2.1.1
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138 3. Studies of Cancer in Experim
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140 1,3-Dihydroxy-2-hydroxymethylan
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142 4.3 Reproductive and developmen
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Table 1 (contd) Test system Result
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146 5.1 Exposure data 5. Summary of
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148 IARC MONOGRAPHS VOLUME 82 Brigg
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150 IARC MONOGRAPHS VOLUME 82 Nusko
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D. SENECIO SPECIES AND RIDDELLIINE
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metry (Witte et al., 1992). Thin-la
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sex were killed after a seven-week
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4.2.2 Experimental systems SOME TRA
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Table 1. Genetic and related effect
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Riddelliine induced unscheduled DNA
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5.3 Animal carcinogenicity data In
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SOME TRADITIONAL HERBAL MEDICINES 1
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SOME MYCOTOXINS
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172 Aflatoxin G 1 IARC MONOGRAPHS V
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Table 2 (contd) Method no. Aflatoxi
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178 indicates that A. flavus and A.
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Table 4. Occurrence of aflatoxin B1
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182 IARC MONOGRAPHS VOLUME 82 aflat
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Table 6. Co-occurrence of aflatoxin
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186 IARC MONOGRAPHS VOLUME 82 Figur
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188 1.4 International exposure esti
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190 (c) Impact of establishing maxi
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192 IARC MONOGRAPHS VOLUME 82 used
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Table 10 (contd) Reference Area Uni
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198 were collapsed into a conventio
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Table 11 (contd) Reference Area Stu
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202 IARC MONOGRAPHS VOLUME 82 histo
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204 IARC MONOGRAPHS VOLUME 82 resid
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Table 12. Summary of principal case
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208 IARC MONOGRAPHS VOLUME 82 disea
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210 3. Studies of Cancer in Experim
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212 IARC MONOGRAPHS VOLUME 82 diet
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214 3.4 Administration with known c
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216 IARC MONOGRAPHS VOLUME 82 The 8
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218 observed in rat liver slices, a
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220 IARC MONOGRAPHS VOLUME 82 Figur
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222 IARC MONOGRAPHS VOLUME 82 an α
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224 (mainly hepatocellular carcinom
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226 IARC MONOGRAPHS VOLUME 82 but i
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228 lordosis and reduction in conce
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232 IARC MONOGRAPHS VOLUME 82 sampl
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234 In eight subjects (four from Ho
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240 IARC MONOGRAPHS VOLUME 82 anima
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242 difference between the two stud
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244 IARC MONOGRAPHS VOLUME 82 HBV-t
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246 In a large cohort study in Shan
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Page 283 and 284: Table 1. IARC evaluations Previous
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Page 287 and 288: 280 2.5.3 Cottonseed A. flavus is a
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Page 311 and 312: 304 1.4 Occurrence Fumonisins have
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Page 333 and 334: 326 4.2.3 Related studies IARC MONO
Page 335 and 336: 328 4.3.2 Experimental systems IARC
Page 337 and 338: 330 and litters on postnatal day 21
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Page 345 and 346: 338 IARC MONOGRAPHS VOLUME 82 treat
Page 347 and 348: 340 4.5.2 Interference with fatty a
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Page 351 and 352: 344 5.2 Human carcinogenicity data
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350 IARC MONOGRAPHS VOLUME 82 Floss
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352 IARC MONOGRAPHS VOLUME 82 Hiroo
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354 IARC MONOGRAPHS VOLUME 82 Lee,
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356 IARC MONOGRAPHS VOLUME 82 Mobio
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358 IARC MONOGRAPHS VOLUME 82 Prelu
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360 IARC MONOGRAPHS VOLUME 82 Savar
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362 IARC MONOGRAPHS VOLUME 82 Steve
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364 IARC MONOGRAPHS VOLUME 82 Flett
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366 IARC MONOGRAPHS VOLUME 82 Yu, C
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368 disulfide, carbon tetrachloride
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Table 1 (contd) Sample matrix Sampl
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Table 3. Naphthalene production (th
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374 1.4 Occurrence 1.4.1 Natural oc
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Table 5. Occupational exposure to n
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378 water assuming a water concentr
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380 (Scheepers & Bos, 1992). The av
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382 (d ) Biodegradation Studies on
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386 3.2 Inhalation exposure 3.2.1 M
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388 3.3.2 Rat Ten BD I and BD III r
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Figure 1. Main metabolic pathways o
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392 IARC MONOGRAPHS VOLUME 82 and t
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394 IARC MONOGRAPHS VOLUME 82 and 1
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396 IARC MONOGRAPHS VOLUME 82 1-240
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398 IARC MONOGRAPHS VOLUME 82 Perfu
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400 Siegel and Wason (1986) reviewe
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402 IARC MONOGRAPHS VOLUME 82 liver
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404 IARC MONOGRAPHS VOLUME 82 to id
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406 IARC MONOGRAPHS VOLUME 82 Alkal
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408 hyperplasia, atrophy, chronic i
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410 had deficient glucose-6-phospha
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Table 10. Genetic and related effec
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Table 10 (contd) Test system Micron
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416 assay with or without metabolic
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418 There is some evidence of devel
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420 IARC MONOGRAPHS VOLUME 82 Bjør
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422 IARC MONOGRAPHS VOLUME 82 Conkl
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424 IARC MONOGRAPHS VOLUME 82 Envir
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426 IARC MONOGRAPHS VOLUME 82 Ho, C
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428 IARC MONOGRAPHS VOLUME 82 Lynch
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430 IARC MONOGRAPHS VOLUME 82 O’B
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432 IARC MONOGRAPHS VOLUME 82 Schee
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434 IARC MONOGRAPHS VOLUME 82 Versc
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STYRENE This substance was consider
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EPA Method 8260B can be used to det
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Styrene is produced mainly by catal
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STYRENE 443 Table 3. Use patterns f
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STYRENE 445 most samples taken from
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STYRENE 447 successive layers of ch
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Table 4 (contd) Country and year of
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Table 5. Biological monitoring of o
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STYRENE 453 Since 1990, the long-te
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same products resulted in exposures
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STYRENE 457 Ambient air monitoring
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200 μg/kg, although 77% of the foo
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Table 8 (contd) Country or region Y
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2.1 Case reports 2. Studies of Canc
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Table 10 (contd) Reference (country
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Table 10 (contd) Reference (country
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STYRENE 469 (95% CI, 1.4-5.2; 10 de
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who had been employed in 1964-70 (t
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elationship for styrene became nega
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atio, 4.4; 95% CI, 1.1-17 in multip
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controls versus 32/32 treated). No
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3.4 Intraperitoneal administration
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Figure 1. Main metabolic pathways f
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STYRENE 483 a maximum and averaged
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(b) Distribution STYRENE 485 An ear
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STYRENE 487 rats with phenobarbital
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STYRENE 489 gavage (100-350 mg/kg b
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CYP2E1 and CYP2F2) inhibited nasal
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model indicated that absorbed styre
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female workers in the glass fibre-r
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STYRENE 497 continuously for seven
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STYRENE 499 exposure concentrations
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STYRENE 501 The frequency of sponta
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STYRENE 503 groups. Only minor gene
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concentrations of styrene in air we
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Table 12. Cytogenetic studies in ly
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Table 13. Genetic and related effec
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(b) Experimental systems (see Table
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STYRENE 515 styrene 7,8-oxide. Joha
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Styrene 7,8-oxide can bind to DNA w
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STYRENE 519 a small and non-signifi
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STYRENE 521 and immune systems, liv
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STYRENE 523 Artuso, M., Angotzi, G.
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STYRENE 525 Brugnone, F., Perbellin
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STYRENE 527 Coccini, T., Maestri, L
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STYRENE 529 Edling, C., Anundi, H.,
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STYRENE 531 Gobba, F., Galassi, C.,
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STYRENE 533 Horvath, E., Pongracz,
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STYRENE 535 logical Study and the I
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STYRENE 537 Linhart, I., Gut, I.,
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STYRENE 539 Miller, S.L., Branoff,
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STYRENE 541 Newhook, R. & Caldwell,
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STYRENE 543 Pryor, G.T., Rebert, C.
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STYRENE 545 Sielken, R.L. & Valdez-
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STYRENE 547 Tsuda, S., Matsusaka, N
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STYRENE 549 Boffetta, P. (1996b) Ex
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Agent SUMMARY OF FINAL EVALUATIONS
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554 IARC MONOGRAPHS VOLUME 82 DGAL:
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556 IARC MONOGRAPHS VOLUME 82 PMTDI
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558 IARC MONOGRAPHS VOLUME 82 Aldri
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560 IARC MONOGRAPHS VOLUME 82 Benz[
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562 β-Butyrolactone 11, 225 (1976)
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564 IARC MONOGRAPHS VOLUME 82 Chlor
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566 Cyproterone acetate 72, 49 (199
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568 IARC MONOGRAPHS VOLUME 82 Diepo
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570 Ethionamide 13, 83 (1977); Supp
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572 IARC MONOGRAPHS VOLUME 82 Haema
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574 L Lasiocarpine 10, 281 (1976);
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576 IARC MONOGRAPHS VOLUME 82 Methy
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578 IARC MONOGRAPHS VOLUME 82 Nicke
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580 O Ochratoxin A 10, 191 (1976);
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582 IARC MONOGRAPHS VOLUME 82 Polyb
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584 Rhodamine 6G 16, 233 (1978); Su
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586 Sulfafurazole 24, 275 (1980); S
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588 1,1,1-Trichloroethane 20, 515 (
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590 Y Yellow AB 8, 279 (1975); Supp
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Volume 31 Some Food Additives, Feed
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