IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC ...

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LIST OF ABBREVIATIONS USED IN THIS VOLUME AA-I: aristolochic acid I AA-II: aristolochic acid II ABS: acrylonitrile–butadiene–styrene ACGIH: American Conference of Governmental Industrial Hygienists AESGP: Association of the European Self-Medication Industry AFAR: aflatoxin aldehyde reductase AFB: B aflatoxins AFB 1: aflatoxin B 1 AFG: G aflatoxins AFM 1: aflatoxin M 1 AFP 1: aflatoxin P 1 AIN: American Institute of Nutrition anti-HBc: antibody to hepatitis B core antigen anti-HBs: antibody to HBsAg AOAC: Association of Official Analytical Chemists AP/AT: atmospheric pressure/ambient temperature APCI: atmospheric pressure chemical ionization AR: aldehyde reductase AUC: area under the curve a w: water activity BASE: Building Assessment Survey and Evaluation CAM: complementary and alternative medicine CBI: covalent binding index CDSL: Commission on Dietary Supplement Labels CHN: Chinese herb nephropathy CI: confidence interval CNS: central nervous system CPA: cyclopiazonic acid CZE: capillary zone electrophoresis dA: deoxyadenosine dAMP: deoxyadenosine 5′-monophosphate dTMP: deoxythymidine 5′-monophosphate dCMP: deoxycytidine 5′-monophosphate dG: deoxyguanosine –553–
554 IARC MONOGRAPHS VOLUME 82 DGAL: Direction Générale de l’Alimentation DGCCRF: Direction Générale de la Concurrence, de la Consommation et de la Répression des Fraudes DMDTC: dimethyldithiocarbamate DMSO: dimethyl sulfoxide DSHEA: Dietary Supplements Health and Education Act EC: European Commission ELEM: equine leukoencephalomalacia ELISA: enzyme-linked immunosorbent assay EMEA: European Agency for the Evaluation of Medicinal Products EN: European norm EQL: estimated quantitation limit ESCOP: European Scientific Cooperative on Phytotherapy ETS: environmental tobacco smoke EU: European Union FAO: Food and Agriculture Organization FB 1: fumonisin B 1 FD: fluorescence detection FDA: Food and Drug Administration FID: flame ionization detection FT–IR: Fourier transform infrared detection GAP: good agriculture practice GC: gas chromatography GEMS: Global Environment Monitoring System GF: growth factor GPA: glycophorin A Gpt: guanine phosphoribosyl transferase GRAS: generally recognized as safe GSH: (reduced) glutathione GST: glutathione S-transferase GSTP: placental glutathione S-transferase HACCP: hazard analysis: critical control point HBsAg: hepatitis B (virus) surface antigen HBV: hepatitis B virus HCC: hepatocellular carcinoma HCV: hepatitis C virus HFB 1: hydrolysed fumonisin B 1 HFB 2: hydrolysed fumonisin B 2 HGF: hepatocyte growth factor HP/HT: high pressure/high temperature HPB: Health Protection Branch HPLC: high-performance liquid chromatography
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WORLD HEALTH ORGANIZATION INTERNATI
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IARC MONOGRAPHS In 1969, the Intern
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iv IARC MONOGRAPHS VOLUME 82 3.2 Th
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vi IARC MONOGRAPHS VOLUME 82 SOME M
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IARC WORKING GROUP ON THE EVALUATIO
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PARTICIPANTS 5 Observer, representi
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PREAMBLE
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10 IARC MONOGRAPHS VOLUME 82 plasms
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12 IARC MONOGRAPHS VOLUME 82 collec
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14 agents present. For processes, i
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16 IARC MONOGRAPHS VOLUME 82 Finall
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18 IARC MONOGRAPHS VOLUME 82 and mi
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20 IARC MONOGRAPHS VOLUME 82 (c) St
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22 IARC MONOGRAPHS VOLUME 82 may le
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24 IARC MONOGRAPHS VOLUME 82 It is
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26 IARC MONOGRAPHS VOLUME 82 Data r
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28 when there is strong evidence th
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30 IARC MONOGRAPHS VOLUME 82 Vol. 7
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GENERAL REMARKS ON THE SUBSTANCES C
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SOME TRADITIONAL HERBAL MEDICINES
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44 which may include, for example,
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46 2. Use of Traditional Herbal Med
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48 IARC MONOGRAPHS VOLUME 82 decade
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50 IARC MONOGRAPHS VOLUME 82 Table
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52 3.2.1 Definition of herbal medic
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54 3.2.8 Individual supply Herbal m
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58 3.3.2 Germany (see Kraft, 1999;
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60 beyond placebo, and this informa
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62 3.3.5 Canada The Canadian Food a
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64 of adverse reactions to OTC drug
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66 IARC MONOGRAPHS VOLUME 82 3.3.12
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68 IARC MONOGRAPHS VOLUME 82 Jellin
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70 IARC MONOGRAPHS VOLUME 82 Simila
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72 IARC MONOGRAPHS VOLUME 82 Figure
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74 diameter of 4-6 cm or more, lobe
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76 1.2 Use 1.2.1 Aristolochia conto
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78 1.3.3 Aristolochia fangchi Compo
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80 1.6.2 Structural and molecular f
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82 chromatographic separation with
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84 may contain aristolochic acids.
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86 IARC MONOGRAPHS VOLUME 82 A bila
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88 received distilled water. The an
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90 IARC MONOGRAPHS VOLUME 82 Figure
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92 varied from undetectable (< 0.02
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94 lochic acids enhanced immune res
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96 4.4 Genetic and related effects
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Table 3 (contd) Details of study DN
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Table 4. DNA adduct formation with
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Table 4 (contd) Details of study Co
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Table 5 (contd) Species Treatment I
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Table 6. DNA adduct formation by ar
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Table 6 (contd) Test system Assay D
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Table 6 (contd) Test system Assay D
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Table 7. Polymerase action on arist
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Table 8 (contd) Test system Drosoph
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116 of the forestomach and lung of
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118 lochic acid II (three metabolit
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120 IARC MONOGRAPHS VOLUME 82 Che,
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122 IARC MONOGRAPHS VOLUME 82 Healt
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124 IARC MONOGRAPHS VOLUME 82 Nishi
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126 IARC MONOGRAPHS VOLUME 82 Schme
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128 IARC MONOGRAPHS VOLUME 82 Yang,
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130 Figure 1. Morinda officinalis H
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132 1.3.2 Morinda officinalis A num
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134 by Soxhlet extraction with ethy
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136 2.1 Case-control studies 2.1.1
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138 3. Studies of Cancer in Experim
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140 1,3-Dihydroxy-2-hydroxymethylan
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142 4.3 Reproductive and developmen
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Table 1 (contd) Test system Result
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146 5.1 Exposure data 5. Summary of
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148 IARC MONOGRAPHS VOLUME 82 Brigg
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150 IARC MONOGRAPHS VOLUME 82 Nusko
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D. SENECIO SPECIES AND RIDDELLIINE
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metry (Witte et al., 1992). Thin-la
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sex were killed after a seven-week
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4.2.2 Experimental systems SOME TRA
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Table 1. Genetic and related effect
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Riddelliine induced unscheduled DNA
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5.3 Animal carcinogenicity data In
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SOME TRADITIONAL HERBAL MEDICINES 1
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SOME MYCOTOXINS
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172 Aflatoxin G 1 IARC MONOGRAPHS V
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Table 2 (contd) Method no. Aflatoxi
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178 indicates that A. flavus and A.
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Table 4. Occurrence of aflatoxin B1
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182 IARC MONOGRAPHS VOLUME 82 aflat
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Table 6. Co-occurrence of aflatoxin
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186 IARC MONOGRAPHS VOLUME 82 Figur
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188 1.4 International exposure esti
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190 (c) Impact of establishing maxi
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192 IARC MONOGRAPHS VOLUME 82 used
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Table 10 (contd) Reference Area Uni
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198 were collapsed into a conventio
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Table 11 (contd) Reference Area Stu
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202 IARC MONOGRAPHS VOLUME 82 histo
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204 IARC MONOGRAPHS VOLUME 82 resid
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Table 12. Summary of principal case
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208 IARC MONOGRAPHS VOLUME 82 disea
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210 3. Studies of Cancer in Experim
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212 IARC MONOGRAPHS VOLUME 82 diet
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214 3.4 Administration with known c
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216 IARC MONOGRAPHS VOLUME 82 The 8
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218 observed in rat liver slices, a
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222 IARC MONOGRAPHS VOLUME 82 an α
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224 (mainly hepatocellular carcinom
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226 IARC MONOGRAPHS VOLUME 82 but i
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228 lordosis and reduction in conce
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232 IARC MONOGRAPHS VOLUME 82 sampl
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234 In eight subjects (four from Ho
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Table 16 (contd) Test system Result
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240 IARC MONOGRAPHS VOLUME 82 anima
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242 difference between the two stud
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244 IARC MONOGRAPHS VOLUME 82 HBV-t
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246 In a large cohort study in Shan
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248 experimental data in showing th
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250 IARC MONOGRAPHS VOLUME 82 Ander
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252 IARC MONOGRAPHS VOLUME 82 Buetl
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254 IARC MONOGRAPHS VOLUME 82 Denis
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256 IARC MONOGRAPHS VOLUME 82 Galla
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258 IARC MONOGRAPHS VOLUME 82 Heino
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260 IARC MONOGRAPHS VOLUME 82 Jalon
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262 IARC MONOGRAPHS VOLUME 82 Kirk,
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264 IARC MONOGRAPHS VOLUME 82 Lunn,
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266 IARC MONOGRAPHS VOLUME 82 Olubu
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268 IARC MONOGRAPHS VOLUME 82 Roll,
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270 IARC MONOGRAPHS VOLUME 82 Stett
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272 IARC MONOGRAPHS VOLUME 82 Verge
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274 IARC MONOGRAPHS VOLUME 82 Yang,
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Table 1. IARC evaluations Previous
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278 kernels and in less than 0.1% o
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280 2.5.3 Cottonseed A. flavus is a
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294 IARC MONOGRAPHS VOLUME 82 8. Re
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296 IARC MONOGRAPHS VOLUME 82 Guo,
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298 IARC MONOGRAPHS VOLUME 82 Marti
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300 IARC MONOGRAPHS VOLUME 82 Sharm
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302 (d ) Solubility: Soluble in wat
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304 1.4 Occurrence Fumonisins have
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306 Table 1 (contd) IARC MONOGRAPHS
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308 (c) Formation in commodities ot
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312 IARC MONOGRAPHS VOLUME 82 3.1 O
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314 3.2.2 Rat IARC MONOGRAPHS VOLUM
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316 with NDEA and fumonisin B 1, wh
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318 IARC MONOGRAPHS VOLUME 82 In pi
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Figure 2. Allometric relationship b
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322 IARC MONOGRAPHS VOLUME 82 obser
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324 IARC MONOGRAPHS VOLUME 82 Hepat
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326 4.2.3 Related studies IARC MONO
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328 4.3.2 Experimental systems IARC
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330 and litters on postnatal day 21
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Table 4. Genetic and related effect
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334 IARC MONOGRAPHS VOLUME 82 The f
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336 IARC MONOGRAPHS VOLUME 82 (d )
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338 IARC MONOGRAPHS VOLUME 82 treat
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340 4.5.2 Interference with fatty a
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344 5.2 Human carcinogenicity data
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346 IARC MONOGRAPHS VOLUME 82 Alber
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348 IARC MONOGRAPHS VOLUME 82 Chamb
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350 IARC MONOGRAPHS VOLUME 82 Floss
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352 IARC MONOGRAPHS VOLUME 82 Hiroo
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354 IARC MONOGRAPHS VOLUME 82 Lee,
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356 IARC MONOGRAPHS VOLUME 82 Mobio
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358 IARC MONOGRAPHS VOLUME 82 Prelu
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360 IARC MONOGRAPHS VOLUME 82 Savar
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362 IARC MONOGRAPHS VOLUME 82 Steve
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364 IARC MONOGRAPHS VOLUME 82 Flett
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366 IARC MONOGRAPHS VOLUME 82 Yu, C
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368 disulfide, carbon tetrachloride
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Table 1 (contd) Sample matrix Sampl
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Table 3. Naphthalene production (th
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374 1.4 Occurrence 1.4.1 Natural oc
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Table 5. Occupational exposure to n
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378 water assuming a water concentr
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380 (Scheepers & Bos, 1992). The av
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382 (d ) Biodegradation Studies on
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386 3.2 Inhalation exposure 3.2.1 M
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388 3.3.2 Rat Ten BD I and BD III r
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Figure 1. Main metabolic pathways o
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392 IARC MONOGRAPHS VOLUME 82 and t
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394 IARC MONOGRAPHS VOLUME 82 and 1
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396 IARC MONOGRAPHS VOLUME 82 1-240
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398 IARC MONOGRAPHS VOLUME 82 Perfu
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400 Siegel and Wason (1986) reviewe
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402 IARC MONOGRAPHS VOLUME 82 liver
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404 IARC MONOGRAPHS VOLUME 82 to id
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406 IARC MONOGRAPHS VOLUME 82 Alkal
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408 hyperplasia, atrophy, chronic i
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410 had deficient glucose-6-phospha
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Table 10. Genetic and related effec
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Table 10 (contd) Test system Micron
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416 assay with or without metabolic
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418 There is some evidence of devel
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420 IARC MONOGRAPHS VOLUME 82 Bjør
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422 IARC MONOGRAPHS VOLUME 82 Conkl
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424 IARC MONOGRAPHS VOLUME 82 Envir
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426 IARC MONOGRAPHS VOLUME 82 Ho, C
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428 IARC MONOGRAPHS VOLUME 82 Lynch
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430 IARC MONOGRAPHS VOLUME 82 O’B
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432 IARC MONOGRAPHS VOLUME 82 Schee
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434 IARC MONOGRAPHS VOLUME 82 Versc
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STYRENE This substance was consider
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EPA Method 8260B can be used to det
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Styrene is produced mainly by catal
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STYRENE 443 Table 3. Use patterns f
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STYRENE 445 most samples taken from
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STYRENE 447 successive layers of ch
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Table 4 (contd) Country and year of
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Table 5. Biological monitoring of o
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STYRENE 453 Since 1990, the long-te
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same products resulted in exposures
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STYRENE 457 Ambient air monitoring
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200 μg/kg, although 77% of the foo
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Table 8 (contd) Country or region Y
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2.1 Case reports 2. Studies of Canc
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Table 10 (contd) Reference (country
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Table 10 (contd) Reference (country
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STYRENE 469 (95% CI, 1.4-5.2; 10 de
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who had been employed in 1964-70 (t
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elationship for styrene became nega
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atio, 4.4; 95% CI, 1.1-17 in multip
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controls versus 32/32 treated). No
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3.4 Intraperitoneal administration
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Figure 1. Main metabolic pathways f
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STYRENE 483 a maximum and averaged
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(b) Distribution STYRENE 485 An ear
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STYRENE 487 rats with phenobarbital
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STYRENE 489 gavage (100-350 mg/kg b
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CYP2E1 and CYP2F2) inhibited nasal
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model indicated that absorbed styre
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female workers in the glass fibre-r
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STYRENE 497 continuously for seven
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STYRENE 499 exposure concentrations
Page 508 and 509: STYRENE 501 The frequency of sponta
Page 510 and 511: STYRENE 503 groups. Only minor gene
Page 512 and 513: concentrations of styrene in air we
Page 514 and 515: Table 12. Cytogenetic studies in ly
Page 516 and 517: Table 13. Genetic and related effec
Page 518 and 519: (b) Experimental systems (see Table
Page 520 and 521: Table 14 (contd) Test system Result
Page 522 and 523: STYRENE 515 styrene 7,8-oxide. Joha
Page 524 and 525: Styrene 7,8-oxide can bind to DNA w
Page 526 and 527: STYRENE 519 a small and non-signifi
Page 528 and 529: STYRENE 521 and immune systems, liv
Page 530 and 531: STYRENE 523 Artuso, M., Angotzi, G.
Page 532 and 533: STYRENE 525 Brugnone, F., Perbellin
Page 534 and 535: STYRENE 527 Coccini, T., Maestri, L
Page 536 and 537: STYRENE 529 Edling, C., Anundi, H.,
Page 538 and 539: STYRENE 531 Gobba, F., Galassi, C.,
Page 540 and 541: STYRENE 533 Horvath, E., Pongracz,
Page 542 and 543: STYRENE 535 logical Study and the I
Page 544 and 545: STYRENE 537 Linhart, I., Gut, I.,
Page 546 and 547: STYRENE 539 Miller, S.L., Branoff,
Page 548 and 549: STYRENE 541 Newhook, R. & Caldwell,
Page 550 and 551: STYRENE 543 Pryor, G.T., Rebert, C.
Page 552 and 553: STYRENE 545 Sielken, R.L. & Valdez-
Page 554 and 555: STYRENE 547 Tsuda, S., Matsusaka, N
Page 556 and 557: STYRENE 549 Boffetta, P. (1996b) Ex
Page 558: Agent SUMMARY OF FINAL EVALUATIONS
Page 563 and 564: 556 IARC MONOGRAPHS VOLUME 82 PMTDI
Page 565 and 566: 558 IARC MONOGRAPHS VOLUME 82 Aldri
Page 567 and 568: 560 IARC MONOGRAPHS VOLUME 82 Benz[
Page 569 and 570: 562 β-Butyrolactone 11, 225 (1976)
Page 571 and 572: 564 IARC MONOGRAPHS VOLUME 82 Chlor
Page 573 and 574: 566 Cyproterone acetate 72, 49 (199
Page 575 and 576: 568 IARC MONOGRAPHS VOLUME 82 Diepo
Page 577 and 578: 570 Ethionamide 13, 83 (1977); Supp
Page 579 and 580: 572 IARC MONOGRAPHS VOLUME 82 Haema
Page 581 and 582: 574 L Lasiocarpine 10, 281 (1976);
Page 583 and 584: 576 IARC MONOGRAPHS VOLUME 82 Methy
Page 585 and 586: 578 IARC MONOGRAPHS VOLUME 82 Nicke
Page 587 and 588: 580 O Ochratoxin A 10, 191 (1976);
Page 589 and 590: 582 IARC MONOGRAPHS VOLUME 82 Polyb
Page 591 and 592: 584 Rhodamine 6G 16, 233 (1978); Su
Page 593 and 594: 586 Sulfafurazole 24, 275 (1980); S
Page 595 and 596: 588 1,1,1-Trichloroethane 20, 515 (
Page 597 and 598: 590 Y Yellow AB 8, 279 (1975); Supp
Page 599 and 600: Volume 31 Some Food Additives, Feed
Page 601: All IARC publications are available
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