IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC ...

Table 10 (contd)
Reference
(country)
Coggon et al.
(1987)
(United
Kingdom)
Bond et al.
(1992)
(USA)
Kolstad et al.
(1993, 1994,
1995)
(Denmark)
Type of plant; study period;
number of subjects; minimal
period employed; follow-up
Production of glass-reinforced
plastics (8 facilities);
1947–84; 7949 subjects; no
minimal employment;
variable, 61.9–99.7%
Dow Chemical workers in
development or production of
styrene-based products;
1940–86; 2904 men; 1 year;
96.7%
Production of glass fibrereinforced
plastics and other
plastics (552 facilities); 1970–
89; 53 720 men and 10 798
women; no minimal
employment; 98.2%
No of
deaths/
cancer
deaths
Results
No. SMR/
SIR
95% CI Site
Comments (previous evaluation)
693/181 6 [0.40] [0.15–0.88] L&H, mortality One of six deaths from L&H with high exposure
to styrene. Extended follow-up of this cohort
included by Kogevinas et al. (1994a,b) (IARC,
1994a)
687/162 15
2
5
56
6
4281/2285
incident
cases
28
174
66
112
42
90
16
0.86
[0.39]
0.49
0.81
0.95
1.4
[1.1]
[1.1]
1.2
1.2
0.87
1.2
0.48–1.4
0.04–1.4
0.16–1.1
0.61–1.0
0.35–2.1
0.95–2.1
[0.93–1.3]
[0.86–1.4]
0.98–1.4
0.88–1.7
0.70–1.1
0.68–1.9
Large intestine
Rectum
Pancreas
Lung
Brain/other nervous
system
L&H
L&H, men/women
Leukaemia, men/women
L&H, men a
Leukaemia, men a
Breast, women
Brain and nervous
system, women
A mortality study, updating of Ott et al. (1980).
From among L&H cancers, elevated incidences
of multiple myeloma and Hodgkin disease
(IARC, 1994a)
Significantly higher incidence of leukaemia
(SIR, 1.6) among men at ≥ 10 years since first
exposure; incidence of leukaemia higher among
short-term male workers with estimated higher
exposure to styrene; part of this cohort included
by Kogevinas et al. (1994a,b) (IARC, 1994a)
STYRENE 465