IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC ...

More documents

Recommendations

Info

PARTICIPANTS 5 Observer, representing the US National Institutes of Health Paul M. Coates, Office of Dietary Supplements, National Institutes of Health, 31 Center Drive, Room 1B29, Bethesda, MD 20892-2086, USA Observer, representing the National Center for Environmental Assessment, US Environmental Protection Agency Gary L. Foureman, EPA (MD-52), National Center for Environmental Assessment, Research Triangle Park, NC 27711, USA Observer, representing the European Centre for Ecotoxicology and Toxicology of Chemicals Trevor Green, Investigative Toxicology Section, Syngenta, Alderley Park, Macclesfield, Cheshire SK10 4TJ, United Kingdom Observer, representing the US National Toxicology Program C. William Jameson, National Toxicology Program, National Institute of Environmental Health Sciences, 79 Alexander Drive, Building 4401, PO Box 12233 (MD EC-14), Research Triangle Park, NC 27709, USA Observer, representing the US National Cancer Institute David Longfellow, Chemical and Physical Carcinogenesis Branch, Division of Cancer Biology, National Cancer Institute, 6130 Executive Boulevard, Suite 5000 MSC7368, Rockville, MD 20892 IARC Secretariat Robert Baan, Unit of Carcinogen Identification and Evaluation (Responsible Officer) Michael Bird 1 John Cheney (Editor) Silvia Franceschi, Unit of Field and Intervention Studies Marlin Friesen, Unit of Nutrition and Cancer Yann Grosse, Unit of Carcinogen Identification and Evaluation Ted Junghans 2 Nikolai Napalkov 3 Christiane Partensky, Unit of Carcinogen Identification and Evaluation (co-Editor) Jerry Rice, Unit of Carcinogen Identification and Evaluation (Head of Programme) 1 Present address: Toxicology Division, ExxonMobil Biomedical Sciences, Inc., 1545 Route 22 East, PO Box 971, Annandale, NJ 08801-0971, USA 2 Technical Resources International Inc., 6500 Rock Spring Drive, Suite 650, Bethesda, MD 20817-1197, USA 3 Present address: Director Emeritus, Petrov Institute of Oncology, Pesochny-2, 197758 St Petersburg, Russian Federation
6 IARC MONOGRAPHS VOLUME 82 Vikash Sewram, Unit of Environmental Cancer Epidemiology Leslie Stayner 1 , Unit of Carcinogen Identification and Evaluation Kurt Straif, Unit of Carcinogen Identification and Evaluation Eero Suonio, Unit of Carcinogen Identification and Evaluation Technical assistance Sandrine Egraz Brigitte Kajo Martine Lézère Jane Mitchell Elspeth Perez 1 Present address: Risk Evaluation Branch, Education and Information Division, Robert A. Taft Labs, C-15, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
Page 1 and 2: WORLD HEALTH ORGANIZATION INTERNATI
Page 3 and 4: IARC MONOGRAPHS In 1969, the Intern
Page 5 and 6: iv IARC MONOGRAPHS VOLUME 82 3.2 Th
Page 7 and 8: vi IARC MONOGRAPHS VOLUME 82 SOME M
Page 10 and 11: IARC WORKING GROUP ON THE EVALUATIO
Page 14: PREAMBLE
Page 17 and 18: 10 IARC MONOGRAPHS VOLUME 82 plasms
Page 19 and 20: 12 IARC MONOGRAPHS VOLUME 82 collec
Page 21 and 22: 14 agents present. For processes, i
Page 23 and 24: 16 IARC MONOGRAPHS VOLUME 82 Finall
Page 25 and 26: 18 IARC MONOGRAPHS VOLUME 82 and mi
Page 27 and 28: 20 IARC MONOGRAPHS VOLUME 82 (c) St
Page 29 and 30: 22 IARC MONOGRAPHS VOLUME 82 may le
Page 31 and 32: 24 IARC MONOGRAPHS VOLUME 82 It is
Page 33 and 34: 26 IARC MONOGRAPHS VOLUME 82 Data r
Page 35 and 36: 28 when there is strong evidence th
Page 37 and 38: 30 IARC MONOGRAPHS VOLUME 82 Vol. 7
Page 40 and 41: GENERAL REMARKS ON THE SUBSTANCES C
Page 42 and 43: GENERAL REMARKS ON THE SUBSTANCES C
Page 44: GENERAL REMARKS ON THE SUBSTANCES C
Page 48: SOME TRADITIONAL HERBAL MEDICINES
Page 51 and 52: 44 which may include, for example,
Page 53 and 54: 46 2. Use of Traditional Herbal Med
Page 55 and 56: 48 IARC MONOGRAPHS VOLUME 82 decade
Page 57 and 58: 50 IARC MONOGRAPHS VOLUME 82 Table
Page 59 and 60: 52 3.2.1 Definition of herbal medic
Page 61 and 62: 54 3.2.8 Individual supply Herbal m
Page 63 and 64:
56 IARC MONOGRAPHS VOLUME 82 Table
Page 65 and 66:
58 3.3.2 Germany (see Kraft, 1999;
Page 67 and 68:
60 beyond placebo, and this informa
Page 69 and 70:
62 3.3.5 Canada The Canadian Food a
Page 71 and 72:
64 of adverse reactions to OTC drug
Page 73 and 74:
66 IARC MONOGRAPHS VOLUME 82 3.3.12
Page 75 and 76:
68 IARC MONOGRAPHS VOLUME 82 Jellin
Page 77 and 78:
70 IARC MONOGRAPHS VOLUME 82 Simila
Page 79 and 80:
72 IARC MONOGRAPHS VOLUME 82 Figure
Page 81 and 82:
74 diameter of 4-6 cm or more, lobe
Page 83 and 84:
76 1.2 Use 1.2.1 Aristolochia conto
Page 85 and 86:
78 1.3.3 Aristolochia fangchi Compo
Page 87 and 88:
80 1.6.2 Structural and molecular f
Page 89 and 90:
82 chromatographic separation with
Page 91 and 92:
84 may contain aristolochic acids.
Page 93 and 94:
86 IARC MONOGRAPHS VOLUME 82 A bila
Page 95 and 96:
88 received distilled water. The an
Page 97 and 98:
90 IARC MONOGRAPHS VOLUME 82 Figure
Page 99 and 100:
92 varied from undetectable (< 0.02
Page 101 and 102:
94 lochic acids enhanced immune res
Page 103 and 104:
96 4.4 Genetic and related effects
Page 105 and 106:
Table 3 (contd) Details of study DN
Page 107 and 108:
Table 4. DNA adduct formation with
Page 109 and 110:
Table 4 (contd) Details of study Co
Page 111 and 112:
Table 5 (contd) Species Treatment I
Page 113 and 114:
Table 6. DNA adduct formation by ar
Page 115 and 116:
Table 6 (contd) Test system Assay D
Page 117 and 118:
Table 6 (contd) Test system Assay D
Page 119 and 120:
Table 7. Polymerase action on arist
Page 121 and 122:
Table 8 (contd) Test system Drosoph
Page 123 and 124:
116 of the forestomach and lung of
Page 125 and 126:
118 lochic acid II (three metabolit
Page 127 and 128:
120 IARC MONOGRAPHS VOLUME 82 Che,
Page 129 and 130:
122 IARC MONOGRAPHS VOLUME 82 Healt
Page 131 and 132:
124 IARC MONOGRAPHS VOLUME 82 Nishi
Page 133 and 134:
126 IARC MONOGRAPHS VOLUME 82 Schme
Page 135 and 136:
128 IARC MONOGRAPHS VOLUME 82 Yang,
Page 137 and 138:
130 Figure 1. Morinda officinalis H
Page 139 and 140:
132 1.3.2 Morinda officinalis A num
Page 141 and 142:
134 by Soxhlet extraction with ethy
Page 143 and 144:
136 2.1 Case-control studies 2.1.1
Page 145 and 146:
138 3. Studies of Cancer in Experim
Page 147 and 148:
140 1,3-Dihydroxy-2-hydroxymethylan
Page 149 and 150:
142 4.3 Reproductive and developmen
Page 151 and 152:
Table 1 (contd) Test system Result
Page 153 and 154:
146 5.1 Exposure data 5. Summary of
Page 155 and 156:
148 IARC MONOGRAPHS VOLUME 82 Brigg
Page 157 and 158:
150 IARC MONOGRAPHS VOLUME 82 Nusko
Page 160 and 161:
D. SENECIO SPECIES AND RIDDELLIINE
Page 162 and 163:
metry (Witte et al., 1992). Thin-la
Page 164 and 165:
sex were killed after a seven-week
Page 166 and 167:
4.2.2 Experimental systems SOME TRA
Page 168 and 169:
Table 1. Genetic and related effect
Page 170 and 171:
Riddelliine induced unscheduled DNA
Page 172 and 173:
5.3 Animal carcinogenicity data In
Page 174 and 175:
SOME TRADITIONAL HERBAL MEDICINES 1
Page 176:
SOME MYCOTOXINS
Page 179 and 180:
172 Aflatoxin G 1 IARC MONOGRAPHS V
Page 181 and 182:
Page 183 and 184:
Table 2 (contd) Method no. Aflatoxi
Page 185 and 186:
178 indicates that A. flavus and A.
Page 187 and 188:
Table 4. Occurrence of aflatoxin B1
Page 189 and 190:
182 IARC MONOGRAPHS VOLUME 82 aflat
Page 191 and 192:
Table 6. Co-occurrence of aflatoxin
Page 193 and 194:
186 IARC MONOGRAPHS VOLUME 82 Figur
Page 195 and 196:
188 1.4 International exposure esti
Page 197 and 198:
190 (c) Impact of establishing maxi
Page 199 and 200:
192 IARC MONOGRAPHS VOLUME 82 used
Page 201 and 202:
Page 203 and 204:
Table 10 (contd) Reference Area Uni
Page 205 and 206:
198 were collapsed into a conventio
Page 207 and 208:
Table 11 (contd) Reference Area Stu
Page 209 and 210:
202 IARC MONOGRAPHS VOLUME 82 histo
Page 211 and 212:
204 IARC MONOGRAPHS VOLUME 82 resid
Page 213 and 214:
Table 12. Summary of principal case
Page 215 and 216:
208 IARC MONOGRAPHS VOLUME 82 disea
Page 217 and 218:
210 3. Studies of Cancer in Experim
Page 219 and 220:
212 IARC MONOGRAPHS VOLUME 82 diet
Page 221 and 222:
214 3.4 Administration with known c
Page 223 and 224:
216 IARC MONOGRAPHS VOLUME 82 The 8
Page 225 and 226:
218 observed in rat liver slices, a
Page 227 and 228:
Page 229 and 230:
222 IARC MONOGRAPHS VOLUME 82 an α
Page 231 and 232:
224 (mainly hepatocellular carcinom
Page 233 and 234:
226 IARC MONOGRAPHS VOLUME 82 but i
Page 235 and 236:
228 lordosis and reduction in conce
Page 237 and 238:
Page 239 and 240:
232 IARC MONOGRAPHS VOLUME 82 sampl
Page 241 and 242:
234 In eight subjects (four from Ho
Page 243 and 244:
Page 245 and 246:
Page 247 and 248:
240 IARC MONOGRAPHS VOLUME 82 anima
Page 249 and 250:
242 difference between the two stud
Page 251 and 252:
244 IARC MONOGRAPHS VOLUME 82 HBV-t
Page 253 and 254:
246 In a large cohort study in Shan
Page 255 and 256:
248 experimental data in showing th
Page 257 and 258:
250 IARC MONOGRAPHS VOLUME 82 Ander
Page 259 and 260:
252 IARC MONOGRAPHS VOLUME 82 Buetl
Page 261 and 262:
254 IARC MONOGRAPHS VOLUME 82 Denis
Page 263 and 264:
256 IARC MONOGRAPHS VOLUME 82 Galla
Page 265 and 266:
258 IARC MONOGRAPHS VOLUME 82 Heino
Page 267 and 268:
260 IARC MONOGRAPHS VOLUME 82 Jalon
Page 269 and 270:
262 IARC MONOGRAPHS VOLUME 82 Kirk,
Page 271 and 272:
264 IARC MONOGRAPHS VOLUME 82 Lunn,
Page 273 and 274:
266 IARC MONOGRAPHS VOLUME 82 Olubu
Page 275 and 276:
268 IARC MONOGRAPHS VOLUME 82 Roll,
Page 277 and 278:
270 IARC MONOGRAPHS VOLUME 82 Stett
Page 279 and 280:
272 IARC MONOGRAPHS VOLUME 82 Verge
Page 281 and 282:
274 IARC MONOGRAPHS VOLUME 82 Yang,
Page 283 and 284:
Table 1. IARC evaluations Previous
Page 285 and 286:
278 kernels and in less than 0.1% o
Page 287 and 288:
280 2.5.3 Cottonseed A. flavus is a
Page 289 and 290:
Page 291 and 292:
Page 293 and 294:
Page 295 and 296:
Page 297 and 298:
Page 299 and 300:
Page 301 and 302:
294 IARC MONOGRAPHS VOLUME 82 8. Re
Page 303 and 304:
296 IARC MONOGRAPHS VOLUME 82 Guo,
Page 305 and 306:
298 IARC MONOGRAPHS VOLUME 82 Marti
Page 307 and 308:
300 IARC MONOGRAPHS VOLUME 82 Sharm
Page 309 and 310:
302 (d ) Solubility: Soluble in wat
Page 311 and 312:
304 1.4 Occurrence Fumonisins have
Page 313 and 314:
306 Table 1 (contd) IARC MONOGRAPHS
Page 315 and 316:
308 (c) Formation in commodities ot
Page 317 and 318:
Page 319 and 320:
312 IARC MONOGRAPHS VOLUME 82 3.1 O
Page 321 and 322:
314 3.2.2 Rat IARC MONOGRAPHS VOLUM
Page 323 and 324:
316 with NDEA and fumonisin B 1, wh
Page 325 and 326:
318 IARC MONOGRAPHS VOLUME 82 In pi
Page 327 and 328:
Figure 2. Allometric relationship b
Page 329 and 330:
322 IARC MONOGRAPHS VOLUME 82 obser
Page 331 and 332:
324 IARC MONOGRAPHS VOLUME 82 Hepat
Page 333 and 334:
326 4.2.3 Related studies IARC MONO
Page 335 and 336:
328 4.3.2 Experimental systems IARC
Page 337 and 338:
330 and litters on postnatal day 21
Page 339 and 340:
Table 4. Genetic and related effect
Page 341 and 342:
334 IARC MONOGRAPHS VOLUME 82 The f
Page 343 and 344:
336 IARC MONOGRAPHS VOLUME 82 (d )
Page 345 and 346:
338 IARC MONOGRAPHS VOLUME 82 treat
Page 347 and 348:
340 4.5.2 Interference with fatty a
Page 349 and 350:
Page 351 and 352:
344 5.2 Human carcinogenicity data
Page 353 and 354:
346 IARC MONOGRAPHS VOLUME 82 Alber
Page 355 and 356:
348 IARC MONOGRAPHS VOLUME 82 Chamb
Page 357 and 358:
350 IARC MONOGRAPHS VOLUME 82 Floss
Page 359 and 360:
352 IARC MONOGRAPHS VOLUME 82 Hiroo
Page 361 and 362:
354 IARC MONOGRAPHS VOLUME 82 Lee,
Page 363 and 364:
356 IARC MONOGRAPHS VOLUME 82 Mobio
Page 365 and 366:
358 IARC MONOGRAPHS VOLUME 82 Prelu
Page 367 and 368:
360 IARC MONOGRAPHS VOLUME 82 Savar
Page 369 and 370:
362 IARC MONOGRAPHS VOLUME 82 Steve
Page 371 and 372:
364 IARC MONOGRAPHS VOLUME 82 Flett
Page 373 and 374:
366 IARC MONOGRAPHS VOLUME 82 Yu, C
Page 375 and 376:
368 disulfide, carbon tetrachloride
Page 377 and 378:
Table 1 (contd) Sample matrix Sampl
Page 379 and 380:
Table 3. Naphthalene production (th
Page 381 and 382:
374 1.4 Occurrence 1.4.1 Natural oc
Page 383 and 384:
Table 5. Occupational exposure to n
Page 385 and 386:
378 water assuming a water concentr
Page 387 and 388:
380 (Scheepers & Bos, 1992). The av
Page 389 and 390:
382 (d ) Biodegradation Studies on
Page 391 and 392:
Page 393 and 394:
386 3.2 Inhalation exposure 3.2.1 M
Page 395 and 396:
388 3.3.2 Rat Ten BD I and BD III r
Page 397 and 398:
Figure 1. Main metabolic pathways o
Page 399 and 400:
392 IARC MONOGRAPHS VOLUME 82 and t
Page 401 and 402:
394 IARC MONOGRAPHS VOLUME 82 and 1
Page 403 and 404:
396 IARC MONOGRAPHS VOLUME 82 1-240
Page 405 and 406:
398 IARC MONOGRAPHS VOLUME 82 Perfu
Page 407 and 408:
400 Siegel and Wason (1986) reviewe
Page 409 and 410:
402 IARC MONOGRAPHS VOLUME 82 liver
Page 411 and 412:
404 IARC MONOGRAPHS VOLUME 82 to id
Page 413 and 414:
406 IARC MONOGRAPHS VOLUME 82 Alkal
Page 415 and 416:
408 hyperplasia, atrophy, chronic i
Page 417 and 418:
410 had deficient glucose-6-phospha
Page 419 and 420:
Table 10. Genetic and related effec
Page 421 and 422:
Table 10 (contd) Test system Micron
Page 423 and 424:
416 assay with or without metabolic
Page 425 and 426:
418 There is some evidence of devel
Page 427 and 428:
420 IARC MONOGRAPHS VOLUME 82 Bjør
Page 429 and 430:
422 IARC MONOGRAPHS VOLUME 82 Conkl
Page 431 and 432:
424 IARC MONOGRAPHS VOLUME 82 Envir
Page 433 and 434:
426 IARC MONOGRAPHS VOLUME 82 Ho, C
Page 435 and 436:
428 IARC MONOGRAPHS VOLUME 82 Lynch
Page 437 and 438:
430 IARC MONOGRAPHS VOLUME 82 O’B
Page 439 and 440:
432 IARC MONOGRAPHS VOLUME 82 Schee
Page 441 and 442:
434 IARC MONOGRAPHS VOLUME 82 Versc
Page 444 and 445:
STYRENE This substance was consider
Page 446 and 447:
EPA Method 8260B can be used to det
Page 448 and 449:
Styrene is produced mainly by catal
Page 450 and 451:
STYRENE 443 Table 3. Use patterns f
Page 452 and 453:
STYRENE 445 most samples taken from
Page 454 and 455:
STYRENE 447 successive layers of ch
Page 456 and 457:
Table 4 (contd) Country and year of
Page 458 and 459:
Table 5. Biological monitoring of o
Page 460 and 461:
STYRENE 453 Since 1990, the long-te
Page 462 and 463:
same products resulted in exposures
Page 464 and 465:
STYRENE 457 Ambient air monitoring
Page 466 and 467:
200 μg/kg, although 77% of the foo
Page 468 and 469:
Table 8 (contd) Country or region Y
Page 470 and 471:
2.1 Case reports 2. Studies of Canc
Page 472 and 473:
Table 10 (contd) Reference (country
Page 474 and 475:
Table 10 (contd) Reference (country
Page 476 and 477:
STYRENE 469 (95% CI, 1.4-5.2; 10 de
Page 478 and 479:
who had been employed in 1964-70 (t
Page 480 and 481:
elationship for styrene became nega
Page 482 and 483:
atio, 4.4; 95% CI, 1.1-17 in multip
Page 484 and 485:
controls versus 32/32 treated). No
Page 486 and 487:
3.4 Intraperitoneal administration
Page 488 and 489:
Figure 1. Main metabolic pathways f
Page 490 and 491:
STYRENE 483 a maximum and averaged
Page 492 and 493:
(b) Distribution STYRENE 485 An ear
Page 494 and 495:
STYRENE 487 rats with phenobarbital
Page 496 and 497:
STYRENE 489 gavage (100-350 mg/kg b
Page 498 and 499:
CYP2E1 and CYP2F2) inhibited nasal
Page 500 and 501:
model indicated that absorbed styre
Page 502 and 503:
female workers in the glass fibre-r
Page 504 and 505:
STYRENE 497 continuously for seven
Page 506 and 507:
STYRENE 499 exposure concentrations
Page 508 and 509:
STYRENE 501 The frequency of sponta
Page 510 and 511:
STYRENE 503 groups. Only minor gene
Page 512 and 513:
concentrations of styrene in air we
Page 514 and 515:
Table 12. Cytogenetic studies in ly
Page 516 and 517:
Table 13. Genetic and related effec
Page 518 and 519:
(b) Experimental systems (see Table
Page 520 and 521:
Page 522 and 523:
STYRENE 515 styrene 7,8-oxide. Joha
Page 524 and 525:
Styrene 7,8-oxide can bind to DNA w
Page 526 and 527:
STYRENE 519 a small and non-signifi
Page 528 and 529:
STYRENE 521 and immune systems, liv
Page 530 and 531:
STYRENE 523 Artuso, M., Angotzi, G.
Page 532 and 533:
STYRENE 525 Brugnone, F., Perbellin
Page 534 and 535:
STYRENE 527 Coccini, T., Maestri, L
Page 536 and 537:
STYRENE 529 Edling, C., Anundi, H.,
Page 538 and 539:
STYRENE 531 Gobba, F., Galassi, C.,
Page 540 and 541:
STYRENE 533 Horvath, E., Pongracz,
Page 542 and 543:
STYRENE 535 logical Study and the I
Page 544 and 545:
STYRENE 537 Linhart, I., Gut, I.,
Page 546 and 547:
STYRENE 539 Miller, S.L., Branoff,
Page 548 and 549:
STYRENE 541 Newhook, R. & Caldwell,
Page 550 and 551:
STYRENE 543 Pryor, G.T., Rebert, C.
Page 552 and 553:
STYRENE 545 Sielken, R.L. & Valdez-
Page 554 and 555:
STYRENE 547 Tsuda, S., Matsusaka, N
Page 556 and 557:
STYRENE 549 Boffetta, P. (1996b) Ex
Page 558:
Agent SUMMARY OF FINAL EVALUATIONS
Page 561 and 562:
554 IARC MONOGRAPHS VOLUME 82 DGAL:
Page 563 and 564:
556 IARC MONOGRAPHS VOLUME 82 PMTDI
Page 565 and 566:
558 IARC MONOGRAPHS VOLUME 82 Aldri
Page 567 and 568:
560 IARC MONOGRAPHS VOLUME 82 Benz[
Page 569 and 570:
562 β-Butyrolactone 11, 225 (1976)
Page 571 and 572:
564 IARC MONOGRAPHS VOLUME 82 Chlor
Page 573 and 574:
566 Cyproterone acetate 72, 49 (199
Page 575 and 576:
568 IARC MONOGRAPHS VOLUME 82 Diepo
Page 577 and 578:
570 Ethionamide 13, 83 (1977); Supp
Page 579 and 580:
572 IARC MONOGRAPHS VOLUME 82 Haema
Page 581 and 582:
574 L Lasiocarpine 10, 281 (1976);
Page 583 and 584:
576 IARC MONOGRAPHS VOLUME 82 Methy
Page 585 and 586:
578 IARC MONOGRAPHS VOLUME 82 Nicke
Page 587 and 588:
580 O Ochratoxin A 10, 191 (1976);
Page 589 and 590:
582 IARC MONOGRAPHS VOLUME 82 Polyb
Page 591 and 592:
584 Rhodamine 6G 16, 233 (1978); Su
Page 593 and 594:
586 Sulfafurazole 24, 275 (1980); S
Page 595 and 596:
588 1,1,1-Trichloroethane 20, 515 (
Page 597 and 598:
590 Y Yellow AB 8, 279 (1975); Supp
Page 599 and 600:
Volume 31 Some Food Additives, Feed
Page 601:
All IARC publications are available
show all

IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC ...

Create successful ePaper yourself

Delete template?

Save as template?