IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC ...

Table 10 (contd)
Reference
(country)
Sathiakumar
et al. (1998)
(USA and
Canada)
Loughlin
et al. (1999)
(USA)
Delzell et al.
(2001)
(USA and
Canada)
Type of plant; study period;
number of subjects; minimal
period employed; follow-up
Styrene–butadiene rubber
plants (n = 8); 1943–91;
15 649 men; one year; 95%
Students attending a school
adjacent to a styrene–butadiene
facility; 1963–95;
15 403 students, 7882 men,
7521 women; 3 months; NR
Styrene–butadiene rubber
plants (n = 6); 1943–91;
13 130 men; one year; vital
status known for > 99%, death
certificates for 98% of the
decedents
No of
deaths/
cancer
deaths
Results
3967/950 87
20
43
349
25
101
48
9
338/44 6
14
7
6
3892/NR 59
59
No. SMR/
SIR
0.97
0.78
0.82
1.01
0.92
1.1
1.3
0.82
[1.1]
[1.2]
[1.3]
[4.2]
3.2
0.8
95% CI Site
0.78-1.2
0.48-1.2
0.60-1.1
0.91-1.1
0.59-1.4
0.88-1.3
0.97-1.7
0.37-1.6
[0.37–2.2]
[0.66–2.0]
[0.51–2.6]
[1.5–9.1]
1.2–8.8
0.2–3.8
Large intestine
Rectum
Pancreas
Lung
Central nervous system
L&H
Leukaemia
Benign neoplasms
Lung
L&H
Leukaemia
Benign neoplasms
Leukaemia (unadjusted)
Leukaemia (adjusted)
Comments (previous evaluation)
Among ever hourly subjects with at least ten
years worked and 20 years since hire:
significantly increased mortality from L&H and
leukaemia (SMRs, 1.5 and 2.2; 49 and 28
deaths)
No data on specific environmental exposures to
chemicals among school students
Within-cohort comparison; the cohort follow-up
reported in Sathiakumar et al. (1998). Relative
risks for the high cumulative exposure to
styrene (18 exposed cases); whether unadjusted,
or adjusted for exposure to 1,3-butadiene and
DMDTC; both models included also terms for
age and years since hire.
L&H, malignancies of the lymphatic and haematopoietic tissues; NR, not reported; SIR, standardized incidence ratio; SMR, standardized mortality ratio; CNS, central nervous
system; DMDTC, dimethyldithiocarbamate
a Only men in the companies producing reinforced plastics
STYRENE 467