IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC ...

Table 10 (contd)
Reference
(country)
Kogevinas
et al.
1994a,b)
(six European
countries)
Wong et al.
(1994)
(USA)
Anttila et al.
(1998)
(Finland)
Type of plant; study period;
number of subjects; minimal
period employed; follow-up
Production of glass fibrereinforced
plastics (660
facilities); 1945–91; varies
between cohorts; 40 688
workers;
97%
Reinforced plastics
manufacturing plants (n = 30);
1948–89; 15 826 subjects;
6 months; 96.5%
Database of workers
biologically monitored for
urinary mandelic acid;
1973–92; 2580 subjects;
no minimal employment;
98.5%
No of
deaths/
cancer
deaths
Results
2714/686 39
21
37
235
18
60
28
1628/425 36
19
162
14
8
31
11
NR/48 1
6
3
5
5
6
2
No. SMR/
SIR
0.77
0.62
1.0
0.99
0.62
0.93
1.0
1.2
1.1
1.4
0.62
0.59
0.82
0.74
0.36
3.1
1.7
0.59
0.62
1.6
0.39
95% CI Site
0.55–1.1
0.38–0.95
0.71–1.4
0.87–1.1
0.37–0.98
0.71–1.2
0.69–1.5
0.83–1.6
0.68–1.8
1.20–1.6
0.34–1.1
0.25–1.2
0.56–1.2
0.37–1.3
0.01–2.0
1.14–6.8
0.34–4.9
0.19–1.4
0.20–1.5
0.59–3.5
0.05–1.4
Colon
Rectum
Pancreas
Lung
Brain
L&H
Leukaemia
Large intestine
Pancreas
Bronchus, trachea, lung
Breast
Central nervous system
L&H
Leukaemia and
aleukaemia
Colon
Rectum
Pancreas
Lung, trachea
Breast
Nervous system
L&H
Comments (previous evaluation)
Risk of L&H increased with latency (p for
trend = 0.012) and with average exposure (p for
trend = 0.019); risk did not increase with
duration of exposure or cumulative exposure.
Non-significant excess risk observed for
pancreas for high cumulative exposure to
styrene (p for trend = 0.068) (IARC, 1994a).
Results presented in this table are for the full
cohort which included a non-exposed group.
Higher risk of L&H among workers with
cumulative exposure > 100 ppm–years at
> 20 years since first exposure (SMR, 1.3;
5 deaths); SMR of lung cancer among workers
with cumulative exposure > 100 ppm–years,
1.0 (34 deaths) (IARC, 1994a)
Both of the L&H cases were Hodgkin
lymphomas.
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IARC MONOGRAPHS VOLUME 82