IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC ...

FUMONISIN B 1
Table 3. Levels of total fumonisins (B1 + B2 + B3) in corn, corn by-products
and the total ration for various animal species recommended in the USA a
Animal or class Recommended maximum level
of total fumonisins in corn and
corn by-products (ppm; mg/kg)
Horse c
Feed
factor b
5 0.2 1
Rabbit 5 0.2 1
Catfish 20 0.5 10
Swine 20 0.5 10
Ruminants d
60 0.5 30
Mink e
60 0.5 30
Poultry f
100 0.5 50
Ruminant, poultry and
mink breeding stock g
30 0.5 15
All others h
10 0.5 5
fumonisins in the high-risk area were 48% in 1989, 79% in 1995 and 73% in 1997; the
corresponding figures in the low-risk area were 25% in 1981, 50% in 1995 and 47% in
1997. Based on local dietary habits, the estimated daily intake of fumonisin B 1 was
1.6–1.9 times higher in the high-risk than in the low-risk area for oesophageal cancer.
The authors noted that aflatoxin B 1 was detected at very low levels in corn samples from
both of the areas. [The Working Group noted that cancer families in high-risk areas were
compared with non-cancer families in low-risk areas.]
3. Studies of Cancer in Experimental Animals
Toxins derived from Fusarium moniliforme were considered by a previous Working
Group in 1992 (IARC, 1993). Since that time, new data have become available and these
have been incorporated into the monograph and taken into consideration in the present
evaluation.
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Recommended maximum
level of total fumonisins in
the total ration (ppm)
a
From Food and Drug Administration (2001c)
b
Fraction of corn or corn by-product mixed into the total ration
c
Includes asses, zebras and onagers
d
Cattle, sheep, goats and other ruminants that are ≥ 3 months old and fed for slaughter
e
Fed for pelt production
f
Turkeys, chickens, ducklings and other poultry fed for slaughter
g
Includes laying hens, roosters, lactating dairy cows and bulls
h Includes dogs and cats