Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

115
(d) Diaminochlorotriazine (DACT)
Species Study Effect NOAEL LOAEL
Rat
Thirteen-week study of
toxicity a
Endocrine disrup-tion
(estrous cycle)
100 ppm, equal to
7.6 mg/kg bw per day
250 ppm, equal to
19.7 mg/kg bw per day
Developmental toxicity b Maternal toxicity 2.5 mg/kg bw per day 25 mg/kg bw per day
Special study, 29/52 weeks a
Embryo/fetotoxicity 2.5 mg/kg bw per day 25 mg/kg bw per day
Endocrine disruption
(LH surge)
48 ppm, equal to
3.4 mg/kg bw per day
270 ppm, equal to
18.8 mg/kg bw per day
Special 19-day study b Female pubertal delay 25 mg/kg bw per day c 50 mg/kg bw per day c
Special 30-day study b Male pubertal delay 6.25 mg/kg bw per day c 12.5 mg/kg bw per day c
Dog
Thirteen-/52-week study of Toxicity 100 ppm, equal to
toxicity a 3.5 mg/kg bw per day
1500/750 ppm, equal to
23.8 mg/kg bw per day
LH, luteinizing hormone.
a
Dietary administration.
b
Gavage administration.
c
Atrazine molar equivalent dose.
(e) Hydroxyatrazine
Species Study Effect NOAEL LOAEL
Rat
Dog
Thirteen-week study of Toxicity 100 ppm, equal to
toxicity a 6.3 mg/kg bw per day
Two-year study of toxicity
and carcinogenicity a
(Sprague-Dawley rats)
Toxicity
Carcinogenicity
25 ppm, equal to 1.0 mg/
kg bw per day
400 ppm, equal to —
17.4 mg/kg bw per day c
300 ppm, equal to
18.9 mg/kg bw per day
200 ppm, equal to
7.8 mg/kg bw per day
Developmental toxicity b Maternal toxicity 25 mg/kg bw per day 125 mg/kg bw per day
Embryo/fetotoxicity 25 mg/kg bw per day 125 mg/kg bw per day
Special 19-day study b Female pubertal delay 200 mg/kg bw per day c,d —
Thirteen-/52-week study of Toxicity 150 ppm, equal to
toxicity a 5.8 mg/kg bw per day
1500 ppm, equal to
59.6 mg/kg bw per day
a
Dietary administration.
b
Gavage administration.
c
Highest dose tested.
d
Atrazine molar equivalent dose.
Estimate of acceptable daily intake for humans
Group ADI for atrazine, deethyl-atrazine (DEA), deisopropyl-atrazine (DIA) and diaminochlorotriazine
(DACT)
0–0.02 mg/kg bw
Hydroxyatrazine
0–0.04 mg/kg bw
Estimate of acute reference dose
ATRAZINE 37–138 JMPR 2007