Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

47
Figure 2. Proposed metabolic pathway for atrazine in primates and humans
N
SCH 2
CHCOOH
NHCOCH 3
N
N
H
N
N
H
CGA-359008
N
SCH 2
CHCOOH
NH 2
N
N
H
N
N
H
Cl
N
N
Cl
N
H
N
Atrazine
Cl
N
H
Cl
H 2
N
N
N
N
N
H
N
N
H 2
N N NH 2
G-30033 G-28273 G-28279
H
N
N
N
N
NH 2
N
SCH 2
CHCOOH
NH 2
N
N
SCH 2
CHCOOH
NH 2
N
N
SCH 2
CHCOOH
NH 2
N
H 2
N
N
N
H
H 2
N N NH 2
N
H
N
NH 2
N
SCH 2
CHCOOH
NHCOCH 3
N
N
SCH 2
CHCOOH
NHCOCH 3
N
H 2
N N N
H 2
N N NH 2
H N NH 2
H
N
CGA-246059 CGA-10582 CGA-30379
N
SCH 2
CHCOOH
NHCOCH 3
N
and greater, also showed chromodacryorrhoea and salivation. No treatment-related gross changes in
organs were seen at necropsy. The LD 50
was 235 mg/kg bw (Sachsse and Bathe, 1975a).
(b)
Dermal irritation
In a study on skin irritation potential, atrazine powder (0.5 g) was applied to intact and abraded
skin of three male and three female Himalayan rabbits. The treated area was occluded for 24 h. A
very slight erythema was observed in three rabbits (abraded) at 24 h after application and in one rabbit
at 72 h. The study differed from present OECD test guidelines in that the test material was not
moistened, the exposure period was for 244 h not 4 h; that abraded skin sites were used in addition
ATRAZINE 37–138 JMPR 2007