Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

226
Hepatocellular Early 0 2 0 2 0 2 1 4 0 0 14 14 0 3 0 3 0 4 0 4 6 11
hypertrophy
Interim 0 10 1 10 0 10 1 10 10 10 10 10 0 10 0 10 0 10 0 10 10 10
Recovery 1 9 — — — — — — 4 10 2 10 — — — — — — — — 1 10
Late 4 18 9 16 7 21 13 22 15 16 6 34 1 26 1 14 1 21 3 15 8 10
Terminal 12 31 6 32 8 27 11 24 32 34 11 16 1 24 6 35 1 29 4 35 28 29
Fatty change Early 0 2 0 2 0 2 1 4 0 0 2 14 0 3 0 3 0 4 0 4 1 11
Interim 2 10 1 10 0 10 2 10 5 10 9 10 0 10 0 10 2 10 1 10 4 10
Recovery 0 9 — — — — — — 0 10 1 10 — — — — — — — — 0 10
Late 0 18 0 16 0 21 0 22 1 16 13 20 0 26 0 14 0 21 0 15 0 10
Terminal 0 31 0 32 0 27 1 24 7 34 7 16 0 24 1 35 0 29 3 35 4 29
Biliary stasis Early 0 2 0 2 0 2 0 4 0 0 1 14 0 3 0 3 0 4 0 4 0 11
Interim 0 10 0 10 0 10 0 10 3 10 10 10 0 10 0 10 0 10 0 10 6 10
Recovery 0 9 — — — — — — 9 10 6 10 — — — — — — — — 9 10
Late 0 18 0 16 0 21 0 22 12 16 20 20 0 26 0 14 0 21 3 15 6 10
Terminal 1 31 0 32 0 27 3 24 32 34 13 16 0 24 0 35 0 29 0 35 29 29
From Cox et al. (1989a)
N, No. of mice with finding; E, No. of mice examined.
a
Fed diet containing difenoconazole at 3000 ppm until day 21.
b
Early unscheduled deaths in weeks 1–52.
c
Interim kill in week 53.
d
Recovery group, killed in week 57.
e
Late unscheduled deaths in weeks 53–79.
f
Terminal kill in weeks 79–80.
g
No histopathology on 10 early deaths (mice ‘replaced’ by mice from control group).
DIFENOCONAZOLE 201–272 JMPR 2007