Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

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Table 9. Pup parameters in rats fed diets containing azinphos-methyl
Parameter
Dietary concentration (ppm)
0 5 15 45
F 1a
Live /dead pups at birth (No.) 252/1 247/0 204/8 197/9
Pups, males/females (%) 52/48 53/47 49/51 52/48
Litter size at day 0/day 5 (No.) 11.5/11.1 11.2/10.5 10.1/8.7* 10.1/3.9**
Viability index (%) 96.8 93.9 86.6** 38.7**
Pups at day 5 a /week 4 (No.) 175/169 167/156 139/134 62/17
Lactation index (%) 96.6 93.4 96.4 27.4**
Body weight at day 0/week 3 (g) 5.8/36.7 5.7/37.5 5.9/35.9 5.4/25.8**
F 1b
Live/dead pups at birth (No.) 235/1 236/11 175/1 133/0
Pups, males/females (%) 52/48 50/50 51/49 55/45
Litter size at day 0/day 5 (No.) 10.6/10.5 9.8/9.5 9.7/9.7 8.9/2.8**
Viability index (%) 98.3 97.3 98.9 31.6**
Pups at day 5 a /week 4 (No.) 165/161 164/162 128/117 39/18
Lactation index (%) 97.6 98.8 91.4* 46.2**
Body weight at day 0/week 3 (g) 5.7/39.9 5.8/39.2 5.9/37.8 5.2**/27.2**
F 2a
Live/dead pups at birth (No.) 259/3 270/0 230/0 43/0
Pups, males/females (%) 55/45 55/45 54/46 51/49
Litter size at day 0/day 5 (No.) 11.7/11.5 11.2/10.8 11.0/10.7 8.6*/7.0*
Viability index (%) 98.1 95.9 97.8 81.4**
Pups at day 5 a /week 4 (No.) 176/173 185/174 152/134 29/21
Lactation index (%) 98.3 94.1 88.7** 72.4**
Body weight at day 0/week 3 (g) 5.7/37.3 5.7/35.6 5.7/36.0 5.4/22.4**
F 2b
Live/dead pups at birth (No.) 223/1 244/2 214/3 25/0
Pups, males/females (%) 51/49 55/45 49/51 56/44
Litter size at day 0/day 5 (No.) 10.6/10.1 11.0/10.0 9.6/8.5 6.2/6.2
Viability index (%) 95.5 90.1* 88.6* 100
Pups at day 5 a
/week 4 (No.) 143/133 165/138 137/123 22/20
Lactation index (%) 93.0 83.6* 89.8 90.9
Body weight at day 0/week 3 (g) 5.8/40.2 5.9/39.6 5.6/37.8 5.8/27.0**
From Eiben & Janda (1987); Annex 1, reference 64, modified by reference to original data.
a
After reduction.
* p < 0.05; ** p < 0.01
dose-related increase in anomalies or malformation in rats or mice. In the second phase, dams in the
group at the highest dose were more sensitive to azinphos-methyl in the latter stages of gestation and
signs of anticholinesterase intoxication, including mortality, were observed. As a result, only 1 litter
out of 13 survived to weaning in this group. The authors concluded that azinphos-methyl had little
primary effect on development in rats and mice (Short et al., 1978; Short et al., 1980; Annex 1, reference
64, modified by reference to original data).
AZINPHOS-METHYL 139–172 JMPR 2007