Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

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Table 10. Tissue distribution of radiolabel in groups of rats receiving [ 14 C]dimethomorph at a
higher dose of 10 mg/kg bw
Tissue
Recovery (% of the total radioactive residues in the administered dose)
t max
24 h 168 h
Males Females Males Females Males Females
GIT contents 74.40 72.33 22.16 21.76 0.01 0.01
GIT 5.30 3.87 2.19 3.35 0.00 0.00
Carcass 4.61 3.62 0.96 3.86 0.04 0.04
Liver 1.14 0.82 0.85 1.05 0.08 0.04
Kidneys 0.08 0.07 0.04 0.08 0.00 0.00
Erythrocytes 0.06 0.02 0.03 0.03 0.01 0.00
Plasma 0.05 0.03 0.04 0.04 0.00 0.00
Lungs 0.03 0.03 0.01 0.03 0.00 0.00
Fat 0.02 0.06 0.00 0.04 0.00 0.00
Heart 0.02 0.02 0.01 0.02 0.00 0.00
Pancreas 0.02 0.02 0.01 0.03 0.00 0.00
Testes 0.02 — 0.01 — 0.00 —
Bone 0.01 0.00 0.00 0.01 0.00 0.00
Muscle 0.01 0.00 0.00 0.02 0.00 0.00
Spleen 0.01 0.01 0.00 0.01 0.00 0.00
Thymus 0.01 0.01 0.00 0.01 0.00 0.00
Adrenals 0.00 0.00 0.00 0.00 0.00 0.00
Bone marrow 0.00 0.00 0.00 0.00 0.00 0.00
Brain 0.00 0.01 0.00 0.01 0.00 0.00
Pituitary 0.00 0.00 0.00 0.00 0.00 0.00
Thyroid 0.00 0.00 0.00 0.00 0.00 0.00
Ovaries — 0.00 — 0.00 — 0.00
Uterus — 0.02 — 0.01 — 0.00
Total 85.79 80.98 26.29 30.37 0.14 0.10
From Bounds (1995)
GIT, gastrointestinal tract.
dead had congested lungs and pallor of the liver, kidneys and spleen. Signs of toxicity were observed
30 min after dosing, including hunched posture, pilo-erection, abnormal gait, lethargy, decreased
respiratory rates. Recovery was not observed before 10 days after dosing. Surviving animals showed
no treatment-related pathological findings (Kynoch, 1985).
To investigate the possible differences in isomer-specific toxicity in Wistar rats, groups of five
male and five female overnight fasted rats were given the dimethomorph Z-isomer (purity not stated)
as a single doses at 0 or 5000 mg/kg bw in 0.1% Tween 80 by oral gavage. Rats were observed for 15
days. The study complied with GLP.
The only finding in the treated rats was pale faeces in the first 2 days after dosing. No signs of
toxicity and no mortalities were recorded within the 2 weeks of observation. Therefore, the median
lethal dose (LD 50
) was greater than 5000 mg/kg bw for males and female (Heusener & Jacobs,
1987a).
DIMETHOMORPH 273–315 JMPR 2007