Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

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Table 20. Findings in offspring and parental rats fed diets containing procymidone for two
generations
Finding
Dietary concentration (ppm)
0 50 250 750
Males Females Males Females Males Females Males Females
Fertile rats (%):
F 1b
93 100 85 97 85 93 97 97
F 1b
76 97 88 86 81 90 89 100
F 2a
79 97 96 93 93 100 42* 86
F 2b
92 93 78 93 81 96 46* 97
Precoital time (days):
F 1a
2.5 3.8 2.0 1.9
F 1b
2.0 2.0 2.1 1.9
F 2a
2.4 2.6 2.1 2.9
F 2b
3.2 2.0 2.0 2.0
Adjusted liver weight (g):
F o
20.6 12.2 20.3 12.1 21.7* 12.4 22.9* 12.9*
F 1
21.5 14.8 21.6 14.7 22.4* 15.5 24.9* 16.7*
F 2
19.8 10.2 19.6 10.3 20.5 10.9* 21.5* 11.2*
Adjusted testes weight (g):
F o
3.8 — 3.8 — 3.9* — 4.1* —
F 1
3.6 — 3.7 — 3.9* — 4.0 —
F 2
3.7 — 3.6 — 3.8 — 3.9* —
Penile abnormalities:
a
F 0
0/30 — 0/30 — 0/30 — 0/30 —
a
F 1
0/30 — 0/30 — 0/30 — 12/30 —
a
F 2
0/30 — 0/30 — 0/30 — 8/30 —
b
F 2b
— — — — — — 21/40 —
Adjusted prostate weight (g):
F 1b
0.22 — 0.22 — 0.19* — 0.17* —
F 2b
0.22 — 0.20 — 0.19 — 0.17* —
Adjusted testes weight (g):
F 1b
1.22 — 1.29* — 1.31* — 1.39* —
F 2b
1.22 — 1.29 — 1.34* — 1.36* —
Adjusted epididymis weight (g)
F 1b
0.16 — 0.16 — 0.14* — 0.13* —
F 2b
0.17 — 0.15 — 0.15 — 0.12* —
From Wickramaratne et al. (1988a) and Milburn & Moreland (1991)
a
Parents.
b
Pups, week 7.
* p < 0.05.
PROCYMIDONE 349–401 JMPR 2007