Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

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Table 9. Tissue distribution of radiolabel in groups of rats receiving [ 14 C]dimethomorph at a
lower dose of 10 mg/kg bw
Tissue
Recovery (% of the total radioactive residues in the administered dose)
t max
24 h 168 h
Males Females Males Females Males Females
GIT contents 67.67 67.52 6.68 9.03 0.01 0.02
GIT 13.91 11.87 0.43 1.06 0.00 0.00
Carcass 7.47 6.89 0.33 0.26 0.04 0.01
Liver 5.36 3.29 0.09 0.75 0.10 0.07
Kidneys 0.25 0.20 0.02 0.02 0.00 0.00
Pancreas 0.10 0.07 0.00 0.00 0.00 0.00
Plasma 0.06 0.10 0.01 0.01 0.00 0.00
Erythrocytes 0.06 0.09 0.01 0.01 0.00 0.00
Heart 0.06 0.04 0.00 0.00 0.00 0.00
Lungs 0.06 0.06 0.00 0.00 0.00 0.00
Fat 0.04 0.09 0.00 0.00 0.00 0.00
Muscle 0.03 0.06 0.00 0.00 0.00 0.00
Spleen 0.02 0.02 0.00 0.00 0.00 0.00
Testes 0.02 — 0.00 — 0.00 —
Bone 0.01 0.02 0.00 0.00 0.00 0.00
Brain 0.01 0.02 0.00 0.00 0.00 0.00
Thymus 0.01 0.02 0.00 0.00 0.00 0.00
Adrenals 0.00 0.01 0.00 0.00 0.00 0.00
Bone marrow 0.00 0.00 0.00 0.00 0.00 0.00
Pituitary 0.00 0.00 0.00 0.00 0.00 0.00
Thyroid 0.00 0.00 0.00 0.00 0.00 0.00
Ovaries — 0.01 — 0.00 — 0.00
Uterus — 0.00 — 0.00 — 0.00
Total 95.16 90.39 6.37 11.14 0.15 0.10
From Bounds (1995)
GIT, gastrointestinal tract.
2. Toxicological studies
2.1 Acute toxicity
(a)
Oral administration
Groups of five male and five female overnight fasted CD rats were given dimethomorph
(purity not stated) as a single dose at 3200, 4000 or 5000 mg/kg bw in 0.1% Tween 80 by oral gavage.
The study complied with GLP.
Mortalities occurred between 24 h and 48 h after dosing. One female died in the group at the
lower dose, three males and four females died in the group at the intermediate dose, and three males
and all females died in the group at the higher dose. Median lethality for males was at 4300 mg/kg
bw, for females at 3500 mg/kg bw, and for both sexes combined, 3900 mg/kg bw. Animals found
DIMETHOMORPH 273–315 JMPR 2007