Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

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Table 4. Identification of metabolites in excreta and cage wash of rats given radiolabelled p yrimethanil by gavage
Sample Recovery in
excreta (%
of administered
dose)
Major metabolites present in excreta (mean % of administered dose)
Polar
m etabolite
SN 614 800 SN 615 224 SN 614 276
sulfate
SN 614 276 SX 614 278 SN 614 277 SN 100 309 Sum of metabolites
Characterized Identified
Single dose at 10 mg/kg bw:
Males
Urine 0–24 h 73.6 26.1 5.7 ND 8.9 30.3 0.8 ND ND 26.1 45.7
Faeces 0–24 h 19.4 5.3 0.3 0.7 1.1 3.8 0.3 2.2 2.1 5.3 10.6
Cage wash 0–24 h 5.1 1.8 0.4 ND 0.6 2.1 0.1 ND ND 1.8 3.2
Sum 98.1 — — — — — — — — 33.2 a 59.4
Total b — — — — — — — — — — 92.6
Females
Urine 0–24 h 71.0 29.7 3.1 ND 12.3 24.8 1.2 ND ND 29.7 41.4
Faeces 0–24 h 20.3 6.4 0.8 1.1 1.4 5.2 0.3 1.8 0.3 6.4 11.0
Cage wash 0–24 h 4.3 1.8 0.2 ND 0.8 1.5 0.1 ND ND 1.8 2.5
Sum 95.6 — — — — — — — — 37.9 a 54.9 a
Total b — — — — — — — — — — 92.8
Single dose at 800 mg/kg bw:
Males
Urine 0–48 h 64.9 19.9 2.5 1.0 4.5 19.3 2.3 7.9 ND 19.9 37.5
Faeces 0–48 h 14.6 4.5 0.7 ND 1.3 2.9 0.3 0.8 2.7 4.5 8.6
Cage wash 0–24 h 11.6 3.5 0.4 0.2 0.8 3.4 0.4 1.4 ND 3.5 6.7
Sum 91.1 — — — — — — — — 28.0 a 52.8 a
Total b — — — — — — — — — — 80.8
Females
Urine 0–48 h 62.1 19.4 4.0 5.0 6.0 14.9 ND 6.8 ND 19.4 36.7
Faeces 0–48 h 16.0 6.8 0.8 ND 1.2 4.4 0.2 0.4 0.6 6.8 7.5
Cage wash 0–24 h 13.4 4.2 0.9 1.1 1.3 3.2 ND 1.5 ND 4.2 7.9
PYRIMETHANIL 445–486 JMPR 2007