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Table 28. Ejaculate mass and testes weights in monkeys (n = 5) given procymidone by gavage for
up to 13 weeks
Parameter a
Dose (mg/kg bw per day)
0 30 100 300
Ejaculate mass (g):
Week −6 0.28 ± 0.27 0.39 ± 0.27 0.65 ± 0.60 0.59 ± 0.47
Week −1 0.69 ± 0.56 0.55 ± 0.22 0.46 ± 0.34 0.63 ± 0.23
Week +4 0.52 ± 0.43 0.41 ± 0.21 0.16 ± 0.19* 0.18 ± 0.18*
Week +8 0.70 ± 0.49 0.26 ± 0.21 0.27 ± 0.22 0.31 ± 0.17
Minimum before dosing 0.28 ± 0.27 0.24 ± 0.14 0.46 ± 0.34 0.41 ± 0.16
Sperm count (10 6 ):
Week −6 167 ± 223 118 ± 139 372 ± 535 133 ± 58
Week −1 174 ± 207 202 ± 151 201 ± 251 349 ± 195
Week +4 133 ± 143 187 ± 83 80 ± 87 75 ± 81
Week +8 121 ± 118 158 ± 149 141 ± 119 180 ± 138
Minimum before dosing 66 ± 54 73 ± 54 76 ± 52 133 ± 58
Relative testes weights (%), week 13 0.60 ± 0.11 0.87 ± 0.11** 0.79 ± 0.21 0.85 ± 0.04**
From Bee (1992)
a
Mean ± standard deviation.
* p < 0.05 vs pre-test (ANOVA).
** p < 0.01 vs values for controls.
Figure 2. Serum testosterone concentrations in monkeys given procymidone by gavage for up to
13 weeks
From Bee (1992)
PROCYMIDONE 349–401 JMPR 2007