Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

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Table 10. Selected studies of genotoxicity with atrazine in vitro
End-point Test system Concentration or dose Purity (%) Results References
Gene mutation
Gene mutation
Gene mutation
Gene mutation
Gene mutation
Gene mutation
Gene mutation
S. typhimurium
TA98, TA100,
TA1535, TA1537,
TA1538
S. typhimurium
TA98, TA100,
TA1535, TA1537
S. typhimurium
TA98, TA100,
TA1535, TA1537
S. typhimurium
TA97, TA98, TA100
S. typhimurium
TA98, TA100
S. typhimurium
TA98, TA100
S. typhimurium
TA98, TA100, TA102,
TA1535, TA1537
50–10 000 µg/plate 98.8 Negative Sutou et al.
(1979)
10–810 μg/plate NR Negative Arni (1978)
20–5 000 μg/plate 98.2 Negative Deparade
(1986)
2–2 157 μg/plate > 99 Negative Butler &
Hoagland (1989)
0.86 mg/ml NR Negative De Veer et al.
(1994)
10–1 000 μg/plate 42.7 a Negative Della Croce et al.
(1996)
1–1 000 μg/plate 98.9 Negative Ruiz & Marzin
(1997)
50–5 000 μg/plate 98.8 Negative Sutou et al.
Gene mutation E. coli
B/r WP2 Tyr - Hcr - (1979)
Gene mutation Chinese hamster V79 1.25–10 mmol/l NR Negative Adler (1980)
cells; HGPRT
Gene mutation CHO cells; HGPRT 0.023–0.23 µg/ml NR Positive Guigas et al.
(1993)
Chromosomal
aberration
CHO cells 1.25–10 mmol/l NR Negative Adler (1980)
Chromosomal
aberration
Chromosomal
aberration
Chromosomal
aberration
Chromosomal
aberration
Micronucleus
formation
Micronucleus
formation
DNA damage and
repair (Rec assay)
Human lymphocytes 0.01–1 µg/ml NR Positive Meisner et al.
(1992)
Human lymphocytes 5–51 µmol/l ≥ 98 Positive Lioi et al. (1998)
Human lymphocytes 5–100 µg/ml 98.4 Negative Ribas et al. (1998)
Human lymphocytes 0.5–50 µg/ml 97.7 Negative Kligerman et al.
(2000a)
Human lymphocytes 1–100 µg/ml 98.4 Negative Surrallés et al.
(1995)
Human lymphocytes 5–200 µg/ml 98.4 Negative Ribas et al. (1998)
B. subtilis H17/M45 100–10 000 µg/well 98.8 Negative Sutou et al. (1979)
SOS chromotest E. coli PQ37 NR 98.9 Negative Ruiz & Marzin.
(1997)
UDS
Rat primary
1.2–150 µg/ml 98.2 Negative Puri (1984a)
hepatocytes
UDS
Human fibroblasts
CRL 1121
1.2–150 µg/ml 98.2 Negative Puri (1984b)
ATRAZINE 37–138 JMPR 2007