Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

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End-point Test system Concentration or dose Purity (%) Results References
UDS
Rat primary
15.5–1 670 µg/ml 97.1 Negative Hertner (1992)
hepatocytes
SCE CHO cells 1.25–10 mmol/l NR Negative Adler (1980)
SCE CHO cells; HGPRT 0.023–0.23 µg/ml NR Negative Guigas et al.
(1993)
SCE
Chinese hamster V79
cells
0.86 mg/ml NR Negative De Veer et al.
(1994)
SCE Human lymphocytes 5–50 µmol/l 98.7 Negative Dunkelberg et al.
(1994)
SCE Human lymphocytes 5–51 µmol/l ≥ 98 Positive Lioi et al. (1998)
SCE Human lymphocytes 5–200 µg/ml 98.4 Negative Ribas et al. (1998)
SCE Human lymphocytes 0.5–50 µg/ml 97.7 Negative Kligerman et al.
(2000a)
Comet assay Human lymphocytes 50–200 µg/ml −S9 98.4 Positive Ribas et al. (1995)
50–200 µg/ml +S9
Negative
Micronucleus
formation b Human lymphocytes 1–100 µg/ml 98.4 Negative Surrallés et al.
(1995)
Mitotic gene
conversion
S. cerevisiae D7 150–350 mmol/l
(stationary phase)
1–10 mmol/l (log
phase)
NR, not reported; SCE, sister-chromatid exchange; UDS, unscheduled DNA synthesis.
a
Formulation tested.
b
Used as biomarker of excision repair.
42.7 a Negative
Positive
Della Croce et al.
(1996)
Table 11. Selected studies of genotoxicity with atrazine in vivo
End-point Test object Concentration or dose Purity (%) Results References
Somatic cells
Chromosomal
aberration
Chinese hamster bone
marrow
500 mg/kg bw; oral, single
dose
NR Negative Basler &
Röhrborn (1978)
Micronucleus
formation
Mouse bone marrow
2000 mg/kg bw; oral,
single dose
NR Negative Ehling (1979)
Chromosomal
aberration
Mouse bone marrow
1500, 2000 mg/kg bw; oral,
single dose
NR Positive Adler (1980)
Nucleus anomaly
test
Chinese hamster bone
marrow
282, 564, 1128 mg/kg bw
per day; oral, on two
consecutive days
NR Negative Hool (1981a)
Chromosomal
aberration
Mouse bone marrow
6 mg/kg, intraperitoneal,
single dose
1 ppm (drinking-water) for
7 weeks
NR Negative Chollet et al.
(1982)
Chromosomal
aberration
Mouse bone marrow
562.5, 1125, 2250 mg/kg
bw; oral, single dose
98.2 Negative Ceresa (1988b)
Chromosomal
aberration
Mouse bone marrow
20 ppm (drinking-water)
over 30 or 90 days
NR Negative Meisner et al.
(1992)
ATRAZINE 37–138 JMPR 2007