Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

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Lowest relevant reproductive NOAEL
Developmental target/critical effect
Lowest relevant developmental NOAEL
50 ppm (4.04 mg/kg bw per day)
Skeletal anomalies, malformations at higher doses
2 mg/kg bw per day (rats)
Neurotoxicity/delayed neurotoxicity
No indications of neurotoxicity in studies of acute toxicity or
repeated doses
Other toxicological studies
Mechanistic studies
Disruption of the hypothalamus–pituitary–testis axis
Necrosis and hyperplasia in the rat bladder
Medical data
No occupational or accidental poisoning reported
Summary
Value Study Safety factor
ADI 0–0.007 mg/kg bw Dog, 1-year study 100
ARfD 0.02 mg/kg bw Rat, study of developmental toxicity 100
References
Alvarez, L. (1990) Teratogenicity study of DPX-H6573-66 in rabbits. Unpublished report No. HLR 216-90
from Haskell Laboratory for Toxicology and Industrial Medicine, DE, USA. Submitted to WHO by E.I. du
Pont de Nemours and Co., Inc., DE, USA.
Alvarez, L., Krauss, W.C. & Staples, R.E. (1984) Developmental toxicity study in rats given INH-6573-66
in the diet on days 7-16 of gestation. Unpublished report No. HLR 431-84 from Haskell Laboratory for
Toxicology and Industrial Medicine, DE, USA. Submitted to WHO by E.I. du Pont de Nemours & Co.,
Inc., DE, USA.
Alvarez, L., Staples, R.E., & Kaplan, A.M. (1985a) INH-6573: prenatal and postnatal toxicity study in rats
dosed by gavage on days 7-16 of gestation. Unpublished report No. HLR 654-85 from Haskell Laboratory
for Toxicology and Industrial Medicine, DE, USA. Submitted to WHO by E.I. du Pont de Nemours & Co.,
Inc., DE, USA.
Alvarez, L., Staples, R.E., Driscoll, C.D. & Kaplan, A.M. (1985b) INH-6573: developmental toxicity study in
rabbits treated by diet on days 7-19 of gestation. Unpublished report No. HLR 337-85 from Haskell Laboratory
for Toxicology and Industrial Medicine, DE, USA. Submitted to WHO by E.I. du Pont de Nemours
& Co., Inc., DE, USA.
Anderson, J.J., Stadalius, M.A. & Schlueter, D.D. (1986) Metabolism of 14 C-DPX-H6573 in rats. Unpublished
report No. AMR-196-84 from E.I. du Pont de Nemours & Co., Inc., DE, USA. Submitted to WHO by
E.I. du Pont de Nemours & Co., Inc., DE, USA.
Arce, G.T., Matarese, C.C. & Sarrif, A.M. (1988) Mutagenicity testing of INH-6573-21 in Salmonella typhimurium
plate incorporation assay. Unpublished report No. HLR 59-88 from Haskell Laboratory for
Toxicology and Industrial Medicine, DE, USA. Submitted to WHO by E.I. du Pont de Nemours & Co.,
Inc., DE, USA.
Brock, W.J. (1988) Primary dermal irritation study with INH-6573-106 in rabbits. Unpublished report No. HLR
484-88 from from Haskell Laboratory for Toxicology and Industrial Medicine, DE, USA. Submitted to
WHO by E.I. du Pont de Nemours & Co., Inc., DE, USA.
Brock, W.J., Rickard, R.W., Kaplan, A.M. & Gibson, J.R. (1985) Long-term feeding study in mice with
INH-6573. Unpublished report No. HLR 278-85 from Haskell Laboratory for Toxicology and Industrial
Medicine, DE, USA. Submitted to WHO by E.I. du Pont de Nemours & Co., Inc., DE, USA.
FLUSILAZOLE 317–347 JMPR 2007