Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

305
(b)
Potentiation of hexobarbiton sleeping time in mice
In six male mice, dimethomorph at a dose of 100 mg/kg bw increased the barbital-induced
mean sleeping time from 187.17 min to 257 min. According to the company, this might be explained
by competition of dimethomorph with barbital for metabolism pathways (Ainsworth & Wright,
1991e).
(c)
Alteration of body temperature in mice
In six male mice, dimethomorph at a dose of 100 mg/kg bw did not alter the body temperature
(Ainsworth & Wright, 1991f).
(d)
Spontaneus motor activity in mice
In six male mice, dimethomorph at a dose of 100 mg/kg bw did not statistically significant
increase spontaneous locomotor activity. However, a very slight increase in grooming was observed
(Ainsworth & Wright, 1991g).
(e)
Tail flick test for analgesia
In six male mice, dimethomorph at a dose of 100 mg/kg bw did not change the reaction time
(tail flicking) to pain. Therefore, dimethomorph has no analgesic activity (Ainsworth & Wright,
1991i).
(f)
Effect on the Irwin test in mice
In groups of five male and five female mice given dimethomorph at a dose of 30, 100 or
300 mg/kg bw, the results of the Irwin test showed very mildly increased incidences of parameters
that suggest a sedative effect (Ainsworth & Wright, 1991k).
(g)
Charcoal meal transit times in the rat small intestines
In groups of five male and five female rats given dimethomorph at a dose of 30, 100 or 300 mg/
kg bw, intestinal motility measured as charcoal-meal transit (migration distance at a certain timepoint
as percentage of the whole length of intestine) was not influenced in males but was increased in
females in a dose-related manner (Ainsworth & Wright, 1991d).
(h)
Effect on motility of uterine smooth muscle in rats
Smooth muscles from preparations of rat uterus were reproducibly induced to contract by acetylcholine
and this contraction could be inhibited by adrenaline. Dimethomorph at concentrations
of up to 30 μg/ml had no effect greater than that of the vehicle (dimethylformamide) on muscle
contraction and did not interfere with the cholinergic and adrenergic receptor dependant reactions
(Ainsworth & Wright, 1991j).
(i)
Assessment of potential anti-inflammatory activity in rats
In groups of eight male and eight female rats given dimethomorph at a dose of 30, 100 or
300 mg/kg bw, the inflammation potential of dimethomorph was investigated by kappa carrageenan
injection in the hind paw. Edema formation was inhibited at 300 mg/kg bw in males (Ainsworth &
Wright, 1991b).
DIMETHOMORPH 273–315 JMPR 2007