Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

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Table 4. Distribution of metabolites in rats given radiolabelled zoxamide as a low dose at 10 mg/kg bw
Metabolite Recovery (% of applied dose)
Single dose Repeated doses
Male Female Male Female
Faeces Urine Subtotal Faeces Urine Subtotal Faeces Urine Subtotal Faeces Urine Subtotal
M-1 (zoxamide) 22.96 — 22.96 12.10 — 12.10 5.56 — 5.56 5.84 — 5.84
M-2 (RH-127,450) 2.75 — 2.75 2.43 — 2.43 2.64 — 2.64 2.28 — 2.28
M-3 (RH-141,643) 7.44 — 7.44 4.93 — 4.93 5.30 — 5.30 5.37 — 5.37
M-4 (RH-141,288) 2.84 — 2.84 3.15 — 3.15 4.02 — 4.02 6.43 — 6.43
M-5 2.46 — 2.46 1.54 — 1.54 2.09 — 2.09 1.76 — 1.76
M-7 (RH-141,454) 5.74 — 5.74 3.73 — 3.73 6.19 — 6.19 2.79 — 2.79
M-8A, M-8B, and M-15 3.36 0.70 4.06 2.94 5.05 7.99 2.22 1.38 3.60 3.84 3.08 6.92
M-9 4.14 — 4.14 3.58 — 3.58 5.12 5.12 3.78 3.78
M-10A, M-10B, M-16, 7.47 4.30 11.77 9.14 4.93 14.07 9.42 5.90 15.32 8.12 3.64 11.76
M-17 (RH‐141,452), and
M-18
M-12 — 0.11 0.11 — 1.09 1.09 — 0.75 0.75 — 1.58 1.58
M-13 — — — — 5.06 5.06 — 0.32 0.32 — 9.64 9.64
M-14A and M-14B — 0.55 0.55 — 1.27 1.27 — 1.67 1.67 — 1.71 1.71
M-19 and M-20 — 1.78 1.78 — 2.65 2.65 — 2.46 2.46 — 2.26 2.26
M-21A and M-21B — 0.94 0.94 — 1.02 1.02 — 1.34 1.34 — 1.48 1.48
Sum of identified metabolites
59.16 8.38 67.54 43.54 21.07 64.61 42.56 13.82 56.38 40.21 23.39 63.60
% of administered dose 87.78 8.84 96.62 73.50 23.17 96.67 78.57 15.30 93.87 71.05 26.45 97.50
submitted for analysis
Total % of administered dose
87.78 10.29 a 98.07 73.50 26.85 c 100.35 78.57 16.27 a 94.84 71.05 28.72 a 99.77
a This includes urine, urine funnel wash and urine cage wash. Urine funnel wash and urine cage wash were not analysed for metabolites.
ZOXAMIDE 487–522 JMPR 2007