Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

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Levels relevant to risk assessment
Species Study Effect NOAEL LOAEL
Mouse
Rat
Eighty-week study
of toxicity and
c arcinogenicity a Toxicity
Carcinogenicity
160 ppm, equal to
20.0 mg/kg bw per day
1600 ppm, equal to
210.9 mg/kg bw per day c
Two-year study Toxicity 400 ppm, equal to
c arcinogenicity a
of toxicity and
17 mg/kg bw per day
Multigeneration
study of reproductive
toxicity a
Carcinogenicity
Parental toxicity
Offspring toxicity
1600 ppm, equal to
210.9 mg/kg bw per day
__
5000 ppm, equal to
221 mg/kg bw per day c —
400 ppm, equal to
23.1 mg/kg bw per day
400 ppm equal to
23.1 mg/kg bw per day
5000 ppm, equal to
221 mg/kg bw per day
5000 ppm, equal to
293.3 mg/kg bw per day
5000 ppm, equal to
293.3 mg/kg bw per day
Rabbit
Dog
Developmental Maternal toxicity 85 mg/kg bw per day 1000 mg/kg bw per day
toxicity b Embryo/fetotoxicity 1000 mg/kg bw per day c —
Developmental Maternal toxicity 45 mg/kg bw per day 300 mg/kg bw per day
toxicity b Embryo/fetotoxicity 45 mg/kg bw per day 300 mg/kg bw per day
Ninety-day and 1-year Toxicity 80 mg/kg bw per day 400/250 mg/kg bw per day
study of toxicity b
a Dietary administration.
b
Gavage administration.
c
Highest dose tested.
Estimate of acceptable daily intake for humans
0–0.2 mg/kg bw per day
Estimate of acute reference dose
Unnecessary
Information that would be useful for continued evaluation of the compound
Results from epidemiological, occupational health and other such observational studies of
h uman exposure
Critical end-points for setting guidance values for exposure to pyrimethanil
Absorption, distribution, excretion, and metabolism in mammals
Rate and extent of oral absorption Rapid and nearly complete absorption; maximum plasma concentration
reached by 1 h
Distribution
Widely distributed in tissues
Potential for accumulation
Low, no evidence of accumulation
Rate and extent of excretion Approximately 97% (77% in urine and 20% in faeces) within 24 h at 11.8
mg/kg bw per day
Metabolism in animals
Extensive; metabolic pathways include aromatic oxidation to form phenols
and conjugation with glucuronic acid and sulfate, minor pathway included
oxidation of methyl group to produce alcohol
Toxicologically significant compounds Pyrimethanil
in animals, plants and the environment
PYRIMETHANIL 445–486 JMPR 2007