Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

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End-point Test object Concentration or dose Purity (%) Results References
Chromosomal
aberration
Chromosomal
aberration
DNA damage
Mouse bone marrow
Mouse bone marrow
Rat stomach, liver and
kidney
Males: 900–1750 mg/kg
bw;
Females: 1400, 1750 mg/kg
bw; oral, single dose
125, 250, 500 mg/kg bw;
intraperitoneal,
two injections 24 h apart
875 mg/kg bw; oral, single
dose
350 mg/kg bw per day;
oral, 5 or 15 days
DNA damage Rat lung 875 mg/kg bw; oral, single
dose
350 mg/kg bw per day;
oral, 5 or 15 days
DNA damage
Germ cells
Chromosomal
aberration
Chromosomal
aberration
Chromosomal
aberrations
Dominant lethal
mutation
Dominant lethal
mutation
Dominant lethal
mutation
Dominant lethal
mutation
Sperm head
morphology
Mouse blood
leukocytes
Mouse spermatogonia
Mouse spermatogonia
Mouse spermatocytes
Mouse spermiogenesis
Mouse spermiogenesis
Mouse spermiogenesis
Mouse spermiogenesis
Mouse sperm
125, 250, 500 mg/kg bw;
intraperitoneal
444, 1332 mg/kg bw
per day; oral, on five
consecutive days
6 mg/kg bw,
intraperitoneal, single dose
1 ppm (drinking-water) for
7 weeks
444, 1332 mg/kg bw; oral,
five doses over 10 days
1500, 2000 mg/kg bw; oral,
single dose
444, 1332 mg/kg bw; oral,
single dose
6 mg/kg, intraperitoneal,
single dose
500, 1000, 2000, 2400 mg/
kg bw; oral, single dose
600 mg/kg bw per day;
intraperitoneal, on five
consecutive days
98.7 Negative
in males
Positive in
females
Gebel et al.
(1997)
97.7 Negative Kligerman et al.
(2000b)
NR Positive Pino et al.
(1988)
NR Negative Pino et al.
(1988)
97.7 Equivocal Tennant et al.
(2001)
NR Negative Hool (1981b)
NR Negative Chollet et al.
(1982)
NR Negative Hool (1981c)
NR Positive Adler (1980)
98.9 Negative Hool (1981d)
NR Negative Chollet et al.
(1982)
97.1 Negative Hertner (1993)
97.2 Negative Osterloh et al.
(1983)
NR, not reported.
respectively, and 0, 0.7, 3.5 and 35.0 mg/kg bw per day for F 1
males and 0, 0.8, 3.8 and 37.5 mg/kg
bw per day for F 1
females, respectively.
No treatment-related mortality or signs of toxicity were observed during the study. Parental
body weights, body-weight gain, and food consumption were statistically significantly reduced at
500 ppm (the highest dose tested) in both sexes and both generations throughout the study. Compared
with controls, body weights for F 0
males and females at the highest dose at 70 days into the study
were decreased by 12% and 15%, respectively, while body weight of the F 1
generation for the same
period was decreased by 15% and 13% for males and females, respectively.
ATRAZINE 37–138 JMPR 2007