Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

311
Lowest relevant inhalation NOAEC
Genotoxicity
Long-term studies of toxicity and carcinogenicity
Target/critical effect
Lowest relevant NOAEL
Carcinogenicity
Reproductive toxicity
Reproduction target/critical effect
Lowest relevant reproductive NOAEL
Developmental target/critical effect
Lowest relevant developmental NOAEL
Neurotoxicity/delayed neurotoxicity
Other toxicological studies
Medical data
No data
Unlikely to be genotoxic in vivo
Liver histology and body-weight decrease (rats)
36.3 mg/kg bw per day
Not carcinogenic
No reproductive effects
80 mg/kg bw per day, the highest dose tested
Increased incidence of total litter losses (rats and rabbits)
60 mg/kg bw per day (rats)
No evidence in conventional studies
In pharmacological studies, evidence for an increase in
phenobarbital sleeping time
Medical surveillance of workers in a plant producing dimethomorph
did not reveal any adverse health effects.
Summary
Value Study Safety factor
ADI 0–0.2 mg/kg bw Dog, 13-week and 1-year study 100
ARfD 0.6 mg/kg bw Rat, study of developmental toxicity 100
References
Afzal, J. & Wu, D. (1995a) Dimethomorph (CL 336,379): blood pharmacokinetics of C-14 CL 336,379 derived
residues in the rat. Unpublished report No. DK-452-008 from XenoBiotic Laboratories, Inc., North Branch,
USA. Submitted to WHO by BASF, Ecully Cedex, France.
Afzal, J. & Wu, D. (1995b) Dimethomorph (CL 336,379): tissue distribution of C-14 CL 336,379 derived residues
in the rat. Unpublished report No. DK-440-013 from XenoBiotic Laboratories Inc., Plainsboro NJ
08536, USA. Submitted to WHO by BASF, Ecully Cedex, France.
Ainsworth, G.A. & Wright, A. (1991a) Anticonvulsive activity in mice. Unpublished report No. DK-451-004
from Toxicol Laboratories Ltd, Ledbury Herefordshire, England. Submitted to WHO by BASF, Ecully
Cedex, France.
Ainsworth, G.A. & Wright, A. (1991b) Assessment of potential anti-inflammatory activity using the carrageenan
induced rat paw oedema model. Unpublished report No. DK-452-004 from Toxicol Laboratories
Ltd, Ledbury Herefordshire, England. Submitted to WHO by BASF, Ecully Cedex, France.
Ainsworth, G.A. & Wright, A. (1991c) Cardiovascular, respiratory and nictitating membrane alterations produced
by test compound in the anaesthetised cat. Unpublished report No. DK-452-006 from Toxicol Laboratories
Ltd, Ledbury Herefordshire, England. Submitted to WHO by BASF, Ecully Cedex, France.
Ainsworth, G.A. & Wright, A. (1991d) Charcoal meal transit times in the rat small intestine. Unpublished
report No. DK-452-003 from Toxicol Laboratories Ltd, Ledbury Herefordshire, England. Submitted to
WHO by BASF, Ecully Cedex, France.
DIMETHOMORPH 273–315 JMPR 2007