Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

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Table 11. Body weight, food consumption and clinical chemistry findings in dogs fed diets
containing zoxamide for 1 year
Finding (means)
Dietary concentration (ppm)
0 1 500 7 500 30 000
Males
Body weight (g):
Week 0 7 846 8 036 7 576 7 882
Week 4 8 939 9 094 8 374 8 136
Week 13 10 640 10 773 10 349 9 466
Week 25 11 623 12 063 11 933 10 718
Week 52 11 734 12 318 12 247 11 041
Body-weight gain (g):
Week 1 169 180 9 36*
Week 4 1 093 1 058 799 254*
Week 13 2 794 2 737 2 773 1 584*
Week 25 3 777 4 027 4 357 2 836
Week 52 3 888 4 283 4 672 3 159
Food consumption (g):
Week 1 290.1 285.7 241.2 217.1
Week 25 324.4 343.1 330.8 359.8
Albumin (g/dl):
Pre-test 3.7 3.3 3.4 3.6
Day 93 3.7 3.7 3.5 3.4*
Day 183 3.7 3.5 3.6 3.3*
Day 274 3.7 3.4 3.4 3.2*
Day 365 3.8 3.7 3.7 3.5
Alkaline phosphatase (U/l):
Pre-test 260 402 498 325
Day 93 190 241 388 367
Day 183 122 168 275 434*
Day 274 117 174 236 412*
Day 365 97 159 200 414*
Females
Body weight (g):
Week 0 7 004 6 781 6 755 6 980
Week 4 7 898 7 658 7 137 6 839*
Week 13 9 242 9 008 8 322 8 035
Week 25 10 176 9 511 9 179 8 503*
Week 52 10 171 9 576 9 293 8 912
Body-weight gain (g):
Week 1 251 415 139 −175*
Week 4 895 877 382* −141*
Week 13 2 238 2 227 1 567 1 056*
Week 25 3 172 2 730 2 425 1 523
ZOXAMIDE 487–522 JMPR 2007