Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

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Table 19. Results of studies of genotoxicity with procymidone
End-point Test object Concentration Purity
(% w/w)
In vitro
Result
Reference
Reverse mutation a
S. typhimurium strains
TA98, TA100, TA1535,
TA1537 and E. coli
(WP2 hcr - )
10–1 000 μg/plate 96.9 Negative +S9 d
Negative − S9
Moriya & Kato
(1977)
Reverse mutation b
S. typhimurium strains
TA98, TA100, TA1535,
TA1537
10–10 000 μg/plate 96.3 Negative +S9 d
Negative −S9
Suzuki &
Miyamoto
(1976)
Reverse mutation b,c,f
S. typhimurium strains
TA98, TA100, TA1535,
TA1537, TA1538 and E.
coli (WP2 uvrA)
5–5 000 μg/plate 99.4 Negative +S9 d
Negative −S9
Kogiso (1991)
Gene mutation
(Hprt locus)
Chinese hamster lung
cells (V79)
0.7–6.0 mmol/l Sumisclex
50% granule
Negative +S9 d
Negative −S9
Principe et al.
(1980)
Nunziata (1982)
Chromosomal
aberration g
Chinese hamster ovary
cells (CHO-K1)
75–300 μg/ml 99.4 Negative +S9 d
Negative −S9
Hara (1991b)
DNA damage
DNA damage b
Bacillus subtilis
(H17 and M45rec - )
Bacillus subtilis
(H17 and M45rec - )
20–2 000 μg/disk 96.9 Negative Moriya & Kato
(1977)
10–10 000 μg/disk 96.3 Negative Suzuki &
Miyamoto
(1976)
Sister chromatid
exchange h
Primary cultures from
ICR mouse embryos
1–100 μmol/l 96.9 Negative +S9 d
Negative −S9
Suzuki (1980)
Unscheduled DNA
synthesis i
Heteroploid human
epithelial cells
6 μmol/l–6.0 mmol/l Sumisclex
50% granule
Negative +S9 d
Negative −S9
Principe et al.
(1980)
Nunziata (1982)
(supplement)
Unscheduled DNA Primary rat hepatocytes 3–300 μg/ml 99.4 Negative Hara (1991a);
synthesis c, f, j Hara (1992)
In vivo
Chromosomal
aberration k Male ddY mice 400, 800 or
1 600 mg/kg bw
intraperitoneally in
corn oil
96.9 Negative Hara & Suzuki
(1980)
Reverse mutation,
host-mediated b Male ICR mice, S.
typhimurium (G46)
Reverse mutation
host-mediated b, l
Male ICR mice, S.
typhimurium (G46)
1 000 or
2 000 mg/kg bw by
gavage in DMSO
2 × 200 and
2 × 500 mg/kg bw by
gavage in 5% gum
arabic
96.3 Negative Suzuki &
Miyamoto
(1976)
96.9 Negative Moriya & Kato
(1977)
Positive controls were included in all tests for genotoxicity and were performed adequately.
DMSO, dimethyl sulfoxide; S9, 9000 × g supernatant from rat livers.
a
Each test was conducted in duplicate.
PROCYMIDONE 349–401 JMPR 2007