Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

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Table 9. Results of studies of acute toxicity with procymidone
Species Strain Sex Route Vehicle LD 50
(mg/kg bw)
LC 50
(mg/l air)
Rat SD M & F Oral Corn oil > 5 000 — 92.3
96.5
Mouse dd M & F Oral Corn oil > 5 000 — 92.3
96.5
Rat SD M & F Dermal Corn oil > 2 500 — 92.3
96.5
Purity (%) Reference
Kadota et al. (1976a)
Segawa (1977)
Kadota et al. (1976a)
Segawa (1977)
Kadota et al. (1976a)
Segawa (1977)
Mouse dd M & F Dermal Corn oil > 2 500 — 92.3
96.5
Kadota et al. (1976a)
Segawa (1977)
Rat SD M & F SC Corn oil > 10 000 — 92.3
96.5
Kadota et al. (1976a)
Segawa (1977)
Mouse dd M & F SC Corn oil > 10 000 — 92.3
96.5
Kadota et al. (1976a)
Segawa (1977)
Rat SD M & F IP Corn oil 850 (M) — 92.3 Kadota et al. (1976a)
730 (F)
Rat SD M & F IP Corn oil 1 440 (M) — 96.5 Segawa (1977)
1 450 (F)
Mouse dd M & F IP Corn oil 1 560 (M) — 92.3 Kadota et al. (1976a)
1 900 (F)
Mouse dd M & F IP. Corn oil 2 030 (M)
2 050 (F)
— 96.5 Kadota et al.
(1976a); Segawa
(1977)
Rat SD M & F Inhalation Fine dust — > 1.5 mg/l
MMAD
< 2.4 μm
99.5 Suzuki & Kato
(1988); Tsuji (1994)
IP, intraperitoneal; F, female; M, male; MMAD, mass median aerodynamic diameter; SC; subcutaneous;
SD, Sprague-Dawley.
(b)
Dermal and ocular irritation and dermal sensitization
Procymidone was a slight transient irritant to rabbit skin (all signs had disappeared by 24 h;
Kadota & Miyamoto, 1976), but produced no irritation to the rabbit eye (Kadota & Miyamoto, 1976).
Procymidone was not a skin sensitizer in guinea-pigs in a repeated injection (10 + 1 doses) protocol
using 1% or 5% w/v preparations in corn oil (Okuno, 1975), nor in a GLP-compliant Magnusson &
Kligman maximization study using concentrations of 1% w/v for intradermal induction, 25% w/v for
topical induction and 25% w/v for challenge application (Nakanishi et al., 1991).
2.2 Short-term studies of toxicity
(a)
Mice
Oral route
Groups of 15 male and 15 female ICR mice received diets containing procymidone (purity,
96.9%) at a concentration of 0, 50, 150 or 500 ppm for 13 weeks. The mice were observed twice per
day for clinical signs of toxicity and mortality and body weights were determined weekly. Food and
PROCYMIDONE 349–401 JMPR 2007