Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

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Table 1. Pharmacokinetic parameters of radioactivity in plasma of female rats, rabbits and monkeys
given a single oral dose of [phenyl- 14 C]procymidone
Parameter
Rats
Dose (mg/kg bw per day)
37.5 62.5 125 250 500
C max
(µg equivalent/ml) 11.48 16.42 30.06 35.67 50.33
T max
(h) 8 12 24 24 24
T 1/2
: from C max
to 120 h (h) 18.3 15.6 16.3 15.9 14.6
AUC 0–120 h
(µg equivalent/h per ml) 450 574 1108 1389 2317
AUC 0–∞
(µg equivalent/h per ml) 454 578 1117 1401 2331
Radioactivity in urine (%) 83 84 81 67 47
Radioactivity in faeces (%) 12 11 15 29 49
Peak PCM (μg equivalent/ml) 3.3 6.1 11.4 10.6 19.4
Peak PCM-NH-COOH a (μg equivalent/ml) 0.8 0.9 1.6 1.9 1.7
Peak PCM-CH 2
OH (μg equivalent/ml) 5.4 7.1 14.4 8.2 19.4
Peak PA-CH 2
OH (μg equivalent/ml) 2.9 7.3 8.3 16.7 8.4
Peak PA-COOH (μg equivalent/ml) 0.7 0.7 1.0 1.7 —
Peak glucuronides (μg equivalent/ml) b 0.5 0.3 0.4 0.7 —
Rabbits
C max
(µg equivalent/ml) — 19.36 29.96 37.22 50.38
T max
(h) — 1 1 1 4
T 1/2
: from C max
to 48 h (h) — 7.0 6.9 7.6 17.6
T 1/2
: from 48 to 120 h (h) — 64.1 47.9 53.4 —
AUC 0–120 h
(µg equivalent/h per ml) — 180 251 457 1244
AUC 0–∞
(µg equivalent/h per ml) — 189 258 474 1260
Radioactivity in urine (%) — 93 81 75 64
Radioactivity in faeces (%) — 4 16 22 35
Peak PCM (μg equivalent/ml) — 0 0.2 0.7 1.0
Peak PCM-COOH (μg equivalent/ml) — 5.1 4.7 7.3 8.0
Peak PCM-CH 2
OH (μg equivalent/ml) — 0 0 0 0
Peak PA-CH 2
OH (μg equivalent/ml) — 0.3 0.8 1.8 2.5
Peak PA-COOH (μg equivalent/ml) — 4.2 8.8 12.7 16.5
Peak glucuronides (μg equivalent/ml) b - 7.0 10.7 11.9 17.8
Monkeys —
C max
(µg equivalent/ml) — 5.92 4.43 8.76 8.69
T max
(h) — 10 6 10 4
T 1/2
: from C max
to 120 h (h) — 81.7 78.9 58.5 84.5
AUC 0–120 h
(µg equivalent/h per ml) — 295 379 563 522
AUC 0–∞
(µg equivalent/h per ml) — 427 600 754 836
PROCYMIDONE 349–401 JMPR 2007