Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

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Table 10. Fertility parameters in rats fed diets containing azinphos-methyl
Parameter
Dietary concentration (ppm)
Males, females Males, females Males, females Males, females
0, 0 5, 5 / 5, 0 45, 45 / 45, 0 15, 15 / 15, 0
Mated females (No.) 36 36/20 36/20 31/20
Insemination index (%) 100 100/100 100/100 100/100
Fertility index (%) 97.2 94.4/100 100/95.0 96.8/100
Gestation index (%) 88.5 100/100 100/100 95.5/95.0
Duration of gestation (days) 22.8 22.4/22.6 22.6/22.7 22.7/22.5
From Holzum (1990); Annex 1, reference 64, modified by reference to original data.
Table 11. F 1
pup parameters in rats fed diets containing azinphos-methyl
Parameter
Dietary concentration (ppm)
Males, females Males, females Males, females Males, females
0, 0 5, 5 / 5, 0 15, 15 / 15, 0 45, 45 / 45, 0
Pups at birth (No.) 240 293 / 216 275 / 196 214 / 211
Pups dead at birth (No.) 13 4 / 2 3 / 1 3 / 3
Live birth index (%) 94.6 98.6* / 99.1* 98.9** / 99.5** 98.6* / 98.6*
Male pups (%) 48.8 / 52.3 48.7 / 48.5 49.5 / 65.4 45
Litter size (No.) 9.9 11.1 / 10.7 10.5 / 10.3 10.0 / 10.9
Viability index (%) 93.4 92.4 / 98.1* 86.0* / 90.8 48.3** / 95.7
Lactation index (%) 62.1 74.2 / — 69.8 / — 57.7 / —
Body weight (g):
Day 0 5.9 5.7 / 5.8 5.8 / 5.9 5.9 / 5.7
Day 5 9.2 8.7 / 8.9 9.0 / 9.3 7.8* / 8.7
Day 14 24.4 22.5 / — 19.9 / — 21.4 / —
Day 28 52.4 52.7 / — 49.5 / — 46.3 / —
From Holzum (1990); Annex 1, reference 64, modified by reference to original data.
* p < 0.05; ** p < 0.01.
Rats
Groups of 33 mated Crl:CD BR CD rats were given azinphos-methyl (purity, 87.7%) at a dose
of 0 (control), 0.5, 1.0 or 2.0 mg/kg bw per day in 6% Emulphor® (EL-719) by gavage on days 6 to
15 of gestation (presence of spermatozoa was counted as day 0 of gestation). From each group, five
dams were killed on day 16 of gestation and the remaining dams were killed on day 20. Appearance,
behaviour, feed consumption, and body-weight gain of the dams were not adversely affected by treatment
at any of the doses tested. On day 16 of gestation, cholinesterase activities in plasma, erythrocytes
and brain were depressed, relative to values for controls, in dams at the highest dose only (fetal
tissues were not examined). By day 20 of gestation, there was indication of recovery in cholinesterase
activity in all previously affected tissues and fetal brain cholinesterase activity was comparable with
control values (Table 13).
Azinphos-methyl did not affect any maternal reproductive parameters and there was no indication
of treatment-related embryotoxicity, fetotoxicity or teratogenicity at any dose. The NOAEL for
AZINPHOS-METHYL 139–172 JMPR 2007