Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

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Table 15 Pup body weights during lactation in a two-generation study of reproductive toxicity in
rats exposed to zoxamide
Mean weights (g)
Dietary concentration (ppm)
0 1000 5000 20 000
P 1
/ F 1a
Pup weight:
Day 0
6.6
6.7
6.7
6.6
Day 7
18.3
17.8
18.5
17.4
Day 14
37.8
35.9
37.3
35.2*
Day 21
60.2
54.5*
54.8*
51.0*
P 1
/ F 1b
Pup weight:
Day 0
6.4
6.4
6.5
6.3
Day 7
17.6
17.2
16.5
16.6
Day 14
36.0
34.6
34.6
33.8
Day 21
58.3
54.4
52.8*
51.2*
P 2
/ F 2a
Pup weight [litter weight]:
Day 0
6.4 [86]
6.3 [92]
6.2 [91]
6.2 [91]
Day 7
17.3 [137]
16.2 [126]
15.8 [117]
15.6* [123]
Day 14
35.4 [280]
34.1 [252]
33.7 [236]
32.4* [243]
Day 21
55.9 [442]
52.1* [386]
49.0* [343]
47.8* [358]
P 2
/ F 2b
a
Pup weight [litter weight]:
Day 0
6.6 [80]
6.3 [92]
6.5 [92]
6.2 [95]
Day 4 – before culling
11.2 [131]
10.0* [140]
9.6* [126]
9.3* [140]
Day 4 – after culling
11.2 [77]
10.0* [76]
9.6* [74]
9.3* [74]
Day 7
18.1 [125]
16.1* [121]
15.7* [113]
15.3* [119]
Day 14
36.1 [242]
35.0 [220]
34.7 [230]
33.4* [247]
Day 14 – pups treated by gavage
35.0
34.1
34.3
33.1
Day 14 – pups on control diet
37.2
36.0
35.1
33.7
Day 21 – pups treated by gavage
57.3
55.3
56.2
54.1
Day 21 – pups on control diet
60.0
56.9
57.6
55.3
From O’Hara et al. (1998)
* Significant difference from control (p