Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

504
Week 52 3 167 2 795 2 538 2 052
Food consumption (g/day):
Week 1 259.9 254.4 250.5 196.4*
Week 25 281.6 252.6 313.5 274.2
Albumin (g/dl):
Pre-test 3.4 3.6 3.5 3.3
Day 93 3.6 3.8 3.6 3.2*
Day 183 3.6 3.8 3.5 3.1
Day 274 3.6 3.8 3.5 3.3
Day 365 3.7 3.6 3.6 3.3*
Alkaline phosphatase (U/l):
Pre-test 283 314 311 290
Day 93 208 177 258 311*
Day 183 170 116 242 297*
Day 274 176 106 219 304*
Day 365 152 108 183 330*
From Ferguson et al. (1998b)
* Significant difference from controls (p < 0.05); ANOVA, Dunnett t-test.
a Mainly due to one dog that lost 397 g in body weight, but consumed typical amounts of food.
Table 12. Organ weights and histopathological findings in dogs fed diets containing zoxamide for
1 year (means)
Finding
Dietary concentration (ppm)
0 1500 7500 30 000
Mean organ weights:
Males
Absolute liver weight (g) 293 330 353 412*
Relative liver weight (%) 2.5 2.7 2.9 3.7*
Absolute thyroid weight (g) 0.81 0.92 1.07 1.04
Relative thyroid weight (%) 0.007 0.007 0.009 0.010
Females
Absolute liver weight (g) 278 276 309 341
Relative liver weight (%) 2.7 2.9 3.4* 3.8*
Absolute thyroid weight (g) 0.73 0.75 0.81 0.98*
Relative thyroid weight (%) 0.007 0.008 0.009 0.011*
Histopathology (No. affected/No. examined):
Males
Liver hypertrophy 0/4 0/4 0/4 2/4
Hepatocellular necrosis 0/4 0/4 0/4 0/4
Females
Liver hypertrophy 0/4 0/4 0/4 1/4
Hepatocellular necrosis 0/4 0/4 0/4 1/4
From Ferguson et al. (1998b)
* Significant difference from controls (p < 0.05); ANOVA, Dunnett t-test.
ZOXAMIDE 487–522 JMPR 2007