Pesticide residues in food — 2007: Toxicological ... - ipcs inchem

343
d
Greater than the maximum tolerated dose (MTD).
Estimate of acceptable daily intake for humans
0–0.007 mg/kg bw
Estimate of acute reference dose
0.02 mg/kg bw
Information that would be useful for the continued evaluation of the compound
Results from epidemiological, occupational health and other such observational studies of
human exposures.
Critical end-points for setting guidance values for exposure to flusilazole
Absorption, distribution, excretion and metabolism in mammals
Rate and extent of oral absorption Rapid and extensive (up to 80%)
Dermal absorption
Distribution
Potential for accumulation
Rate and extent of excretion
Metabolism in animals
Toxicologically significant compounds in animals,
plants and the environment
Data not available
Widely
Low
Rapidly excreted
Extensively metabolized
Parent compound,1,2,4-triazole
Acute toxicity
Rat, LD 50
, oral 674 mg/kg bw
Rat, LD 50
, dermal
Rat, LC 50
, inhalation
Guinea-pig, skin sensitization (test method used)
> 2000 mg/kg bw
2.7–3.7 mg/l, 4 h
Non-sensitizing (Buehler)
Short-term studies of toxicity
Target/critical effect
Lowest relevant oral NOAEL
Lowest relevant dermal NOAEL
Lowest relevant inhalation NOAEC
Liver and urinary bladder
0.7 mg/kg bw per day (1-year study in dogs)
5 mg/kg bw per day (21-day study in rabbits)
No data presented
Genotoxicity
Not genotoxic
Long-term studies of toxicity and carcinogenicity
Target/critical effect
Lowest relevant NOAEL
Carcinogenicity
Liver and bladder
2.0 mg/kg bw per day (2-year study in rats)
No carcinogenic concern at levels of dietary exposure
Reproductive toxicity
Reproduction target/critical effect
Increased gestation length, reduced live born pups/litter and
decreased pup growth
FLUSILAZOLE 317–347 JMPR 2007