Photonic crystals in biology

Poster Session, Tuesday, June 15
Theme A1 - B702
Amyloid-like peptidic template-directed synthesis of inorganic nanomaterials
Ruslan Garifullin, Mustafa Özgür Güler*
UNAM-Institute of Materials Science and Nanotechnology, Bilkent University, Ankara 06800, Turkey
Abstract— We have designed amyloid like peptides self-assembling into nano-sized fibrilar structures. These assemblies are
further exploited as a universal nano-template for synthesis of inorganic materials through the mineralization process. Our
method of using mineralization process to produce inorganic nanostructures is unique as it realizes “bottom-up” molecular
design concept.
Self-assembly is an important technique for materials design
using non-covalent interactions including hydrogen bonding,
hydrophobic, electrostatic, metal-ligand, - and van der
Waals interactions. 1 Nanostructures inspired from biological
systems have been investigated for use in electronics 5-7 ,
optics 8 and regenerative medicine 9 , among other
HO
O
O
NH
O
functional group
H
N
R 1
O
N
H
R 2
O
O R
H
4
O
H
N
N
N
R H
OH
3 O
O NH 2
beta-sheet forming peptide
functional
group
Figure 1. Representation of self-assembling peptidic unit.
Cobalt (II) oxide is not the only inorganic material that we
succeeded to synthesize. We also had positive results with
copper (II) oxide, zinc oxide, titanium (II) oxide and many
other metals. The ability to realize in practice this number of
inorganic compounds truly testifies that designed template is
universal and at the same time proves our concept of templatedirected
synthesis.
In summary, having shown feasibility of the method we
propose to employ soft-materials templating approach to
create one-dimensional nanostructures. Novel supramolecular
architectures will be built molecule-by-molecule, thus
realizing “bottom-up” approach. By using non-covalent
intermolecular forces, it will be possible to construct dynamic
self-assembled systems. Highly tailorable small molecules
facilitate incorporation of multifunctional groups for
controlled morphology, chemical and physical characteristics,
and surface chemistry. Controlled formation of shape at
nanoscale will enable researchers to investigate novel
multifunctional nanodevices.
Acknowledgement. This work is supported by TUBITAK.
*Corresponding author: moguler@unam.bilkent.edu.tr
Figure 2. TEM image of peptide nanofibers (left) and template
directed synthesis of Cobalt(II) oxide nanotubes(right).
applications. 10-13 Supramolecular chemistry opens interesting
opportunities for new technology by directing the structure
and function of materials at 1-100 nm scale, a length-scale
which is difficult to access through conventional covalent
2, 14-16
chemistry.
In this work, we explored the idea of forming nanofibers by
means of self-assembly of amyloid-like peptides and found
that self-assembly is achieved by specially designed short
peptide sequences that can form sheet-like hydrogen bonded
structures. Moreover, functional groups can be relatively
easily introduced to the peptidic molecules and it is possible to
control nanostructure surface morphology by affecting the
hydrogen bonding orientation. These results suggest that
obtained nanofibers can further be used as a template in
synthesis of inorganic nanomaterials.
We studied formation of several metal oxides and metal
sulfides through mineralization process. Metal salts were
deposited on the surface of the preformed template, and the
template was removed by calcination process. We found that
this method is, indeed, feasible. For instance, cobalt (II) oxide
formed nanotubes. Structure of nanotubes was verified and
characterized by SEM-EDAX and TEM.
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6th Nanoscience and Nanotechnology Conference, zmir, 2010 400