Kerala State Drug Formulary.pdf

Sulphonamides
A/E: same as in ciprofloxacin & tachycardia, inflammation
of tongue/mouth, vaginitis, hallucination.
P/A: Tablet (5) of 200mg Rs 8.50-50/-;Tablet(5) of 400mg
Rs 25.00/-
Dose: 400mg OD
Fourth generation fluoroquinolones
Enhanced activity against g+ve organisms;significantly greater activity
against Anaerobes
Example: Moxifloxacin
Moxifloxacin
I: A/c bacterial sinusitis, CAP, skin infection, intra
abdominal infection
C/I: Hypersensitivity, Age< 18, pregnancy, lactation,
bradycardia, heart failure, hypokalemia.
A/E: Similar to ciprofloxacin & hematological disturbances,
peripheral neuropathy.
P/A: Tablet(5) of 400mg Rs 350/;Injection 400mg - Rs 160/
Dose: 400mg OD
SULPHONAMIDES
Cotrimoxazole (Trimethoprim + Sulphamethoxazole)
l: Acute uncomplicated UTI (except those by enterococci),
prevention of recurrent UTI, shigellosis, enteric fever,
typhoid carrier, pneumocystis carinii infection,
brucellosis, cdonovanosis, listeriosis, legionellosis, non
tuberculous mycobacterial skin diseases, pertussis,
acute maxillary sinusitis and plague.
C/I: Creatinine clearance < 15 ml / min, infants < 2 months,
pregnancy at term and during lactation.
P/C: Renal disease, history of hypersensitivity to
sulphonamides, patients taking pyrimethamine,
immunocompromised patients.
A/ E: Precipitates megaloblastic anaemia, leukopenia,
thrombocytopenia, exfoliative dermatitis, Stevens
Johnson syndrome, toxic epidermal necrolysis, nausea,
vomiting, stomatitis, aplastic, haemolytic and
macrocytic anemia, coagulation disorders,
sulphahaemoglobinaemia, nausea, crystalluria.
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