Kerala State Drug Formulary.pdf

Ulcer Healing Drugs
mecamylamine,pseudoephedrine and quiniuine rate of
elimination is reduced.
Cost: (Combination) Gelusil tab (10)-Rs.1.81;
Liquid - (170 ml) -Rs.13.50
H2 RECEPTOR ANTAGONISTS
Ranitidine
In general the H 2receptor antagonists and proton pump inhibitors are
given in full doses for 4·6 weeks and thereafter at a lower doses for 1 or 2
months by which time ulcer would have healed.Cigarette smoking,alcoholism
and irregular timing of food are the common causes for relapse ofthe ulcer.
These should be avoided.
I : Duodenal ulcer, gastric ulcer, stress ulcers and gastritis,
reflux oesophagitis, Zollinger- Ellison syndrome,
prophylaxis of aspiration pneumonia during anaesthesia
and surgery.
C/I : Known hypersensitivity to the drug.
P/C: Impaired renal function, pregnancy and lactation, not
recommended for children below 8 years. Exclude
gastric malignancy before starting treatment. It may
cause headache, dizziness and rarely hepatitis and
thrombocytopenia.
A/E Headache, Diarrhoea/constipation and dizziness
P/A: Tablets 150 mg, 300 mg
Injection 50 mg / 2 mL
Dose : For ulcer healing : 150 mg bd or 300 mg at hs for
4 -5 weeks Maintenance ; 150 mg at hs for 6 months to
1 year.
Zollinger-Ellison syndrome :
150 mg tds. to a maximum of 900 mg / day in divided
doses.
Parenteral : IM 50 mg 6 to 8 hourly IV 2 mL ampoule to
20 mL with Normal saline and inject over ≥5 minutes
every 6 to 8h.
D/ I : It does not significantly inhibit hepatic metabolism of
other drugs.
Cost: Tab. 150 mg (10)Rs. 6.76;
Inj. 25 mg/ml(1 vial)Rs. 2.30
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