Kerala State Drug Formulary.pdf

Antineoplastic Drugs
Cost :
5-Fluorouracil
I :
C/I:
P/C :
agents enhance antineoplastic effect of
mercaptopurine. Trimethoprim-sulfamethoxazole
enhances bone marrow suppression
Tab 50 mg Rs210-Rs765
Adjuvant in the treatment of carcinoma of breast,
pancreas, urinary bladder, hepatoma, carcinoma of
colon, and other parts of Gl tract, premalignant
keratosis of skin (topical treatment), multiple
superficial basal cell carcinoma.
Serious infection, depressed bone marrow function.
Anemia, leucopenia, skin pigmentation, hepatic or renal
impairment hypersensitivity.
A/E : Nausea, vomiting, diarrhoea, alopecia conjunctivitis,
bone marrow depression, angina pectoris, cardiac
arrhythmias, oral and Gl ulcers, hyperpigmentaion,
chestpain, breathlessness.
P/A: Injection 250 mg, 500 mg ampoules,Cream 5%
Dose : 12 mg/kg o.d. x 4 days I.V. (maximum 8000 mg) .
If no toxicity 6 mg/kg on days 6, 8, 10, 12.
Maintenance 10 - 15 mg / Kg/ week.
D/I : Other bone marrow depressants immunosuppresive
agents, irradiation all lead to additive effect. With
leucovorin, calcium toxicity of 5 flurouracil increased.
Enhanced toxicity with metronidazole. Elevation in
alkaline phosphatase and transaminases, serum bilirubin
Cost: Inj: 50 mg vial – Rs. 19.00
Cytarabine (cytosine arabinoside)
I : AML, ALL, CML blast phase, NHL in children. Treatment
and maintenance of meningeal neoplasms,
Erythroleukemia.
C/I : Pregnancy, lactation
P/C: Monitor hepatic function, haematological parameters,
uric acid levels, women of child bearing age, intrathecal
administration in, infants.
A/E: Leucopenia, anaemia, thrombocytopenia, reticulo
cytopenia, GI disturbances, oral and anal
ulcerations,hepatic and renal dysfunction,
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