Kerala State Drug Formulary.pdf

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Diuretics metabolic oedema with abnormal capillary fragility; severe dehydration; renal failure (unless test dose produces diuresis) P/C: monitor fluid and electrolyte balance; monitor renal function P/A: Injectable solution: 10%; 20%. Solutions containing more than mannitol 15% may crystallize during storage, crystals must be redissolved by warming solution before use and solution must not be used if any crystals remain; intravenous administration sets must have a filter; mannitol should not be administered with whole blood or passed through the same transfusion set as blood Dose: Test dose if patient oliguric or renal function is inadequate, by intravenous infusion, as a 20% solution, 200 mg/kg body weight infused over 3–5 minutes; repeat test dose if urine output less than 30–50 ml/hour; if response inadequate after second test dose, re-evaluate patient.Raised intracranial or intraocular pressure, by intravenous infusion, as a 20% solution infused over 30– 60 minutes, ADULT 0.25–2 g/kg; CHILD 0.5–1.5 g/kg Cerebral oedema, by intravenous infusion, as a 20% solution infused rapidly,ADULT and CHILD 1 g/kg body weight A/E: Fluid and electrolyte imbalance, circulatory overload, acidosis; pulmonary oedema particularly in diminished cardiac reserve; chills, fever, chest pain, dizziness, visual disturbances; hypotension or hypertension; urticaria, hypersensitivity reactions; extravasation may cause oedema, skin necrosis, thrombophlebitis;rarely, acute renal failure (large doses) 214
SECTION 15 DRUGS USED IN DENTISTRY Generally medicines used in dentistry are the same as those in the field of medicine.This is especially true for the surgical departments in dentistry.But lot of substances are used in dentistry which finds application only in dentistry as far as medical field is concerned. Analgesics Aspirin I: Mild to moderate dental pain Dose : 300 – 600 mg. 6 – 8 hourly orally Paracetamol I: Mild to moderate dental pain where anti-inflammatory action is not required and following simple dental extractions Dose : 500 mg. 8 hourly Ibuprofen I: Mild to moderate pain following traumatic dental extractions Antibiotics generally used in Dentistry Phenoxy methyl penicillin out patient odontogenic infections Ampicillin dentoalveolar infections Amoxycillin drug of choice for prophylaxis of infective endocarditis in patients undergoing surgical procedures Erythromycin used in patients allergic to penicillin Clindamycin useful in oral infections especially in Ludwig’s angina Other drugs used. Doxycycline, Cloxacillin, Ciprofloxacin, Amoxycillin+Clavulanic acid and Ofloxacin Metronidazole gel 1% - topical dressing in periodontal conditions Tinidazole, Ornidazole are also used 215
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KERALA STATE DRUG FORMULARY NUMBER
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CENTRAL DRUG FORMULARY COMMITTEE CH
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LIST OF CONTRIBUTORS 1. Dr. K.V. Kr
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FOREWORD Medicines play a crucial r
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Dr. V. Geetha, Director of Medical
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ABBREVIATIONS A/E .................
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Antiretroviral drugs ..............
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Dyes used in ophthalmology ........
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Antipsychotic drugs ...............
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Eclampsia .........................
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PART - I GENERAL ADVICE TO PRESCRIB
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General advice to Prescribers Monit
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General advice to Prescribers Pharm
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General advice to Prescribers refil
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General advice to Prescribers neces
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General advice to Prescribers 2C19
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General advice to Prescribers possi
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General advice to Prescribers Cost
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General advice to Prescribers Did w
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Inhalational agents I:, C/I:,D/I: s
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Intravenous General Anaesthetics Re
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Local Anaesthetics anaesthesia. Low
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Local Anaesthetics A/E: P/A: Dose:
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Preoperative Medication PREOPERATIV
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Preoperative Medication A/E: P/A: D
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SECTION - 2 ANALGESICS, ANTIPYRETIC
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Non-Steroidal Anti-Inflammatory Dru
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Opioid Analgesics P/A : Injection:
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Opioid Analgesics pain, 100 mg init
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Drugs in Rheumatoid Disorders P/A:
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Drugs in Rheumatoid Disorders IMPOR
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Medicines used for Gout Dose: Admin
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SECTION - 3 ANTI CONVULSANTS/ANTIEP
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Antiepileptics A/E: Cardiovascular
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Antiepileptics Ethosuximide I: Drug
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Antiepileptics hypotonia, coordinat
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Antiepileptics Topiramate I: Adjunc
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Antiepileptics Felbamate I: Unrespo
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SECTION - 4 ANTIINFECTIVE DRUGS ANT
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Pencillins Phenoxymethyl penicillin
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Cephalosporins Cephazolin I: Surgic
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Pencillins Cefdinir I: Pneumonia, c
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Aminoglycosides Gentamicin I: Urina
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Broad spectrum antibiotics I: Ricke
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Macrolides pertussis, endemic trach
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Macrolides photosensitivity; hepati
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Teicoplanin Cost: Tab 50 mg (10) Rs
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Fluoroquinolones A/E: Nausea, epiga
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Sulphonamides A/E: same as in cipro
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Antifungal drugs Sulphacetamide I:
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Antiviral drugs ANTI VIRAL DRUGS An
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Non selective antiviral drugs Dose:
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Antiretroviral drugs Dose: Oral, 30
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Antiretroviral drugs A/E : Rash inc
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Antimalarial drugs Artesunate I: Ml
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Antimalarial drugs Quinine I: Acts
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Antiamoebic and other protozoal dru
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Anthelmintics drugs Other drugs use
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Antifilarial drugs SCHISTOSOMICIDES
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SECTION - 5 ANTIMIGRAINE MEDICINES
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SECTION 6 ANTINEOPLASTIC DRUGS ALKY
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Antimetabolites Cost : Inj: 1 g via
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Antineoplastic Drugs Cost : 5-Fluor
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Cytotoxis Antibiotics P/A: Injectio
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Mitotic Inhibitors Epirubicin I: Ca
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Hormones and Hormonal antagonists P
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Targeted agents Progestins Medroxy
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Cytoprotective agents A/E: Infusion
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Dopaminergic agonist P/A: Dose: Bro
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MAO B Inhibitor MAO B Inhibitor Sel
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Central Anticholinergics daily (wit
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SECTION - 8 DRUGS ACTING ON BLOOD A
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Drug affecting Coagulation P/C: Can
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Haemolytic Anaemias HAEMOLYTIC ANAE
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Iron chelating drugs iron, aluminiu
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Acute Myelogenous Leukemia (All Tra
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Chronic Lymphocytic Leukemia dyspne
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Antiplatelet drugs Dose: 300 mg in
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Thrombolytic drugs Cost: lnj vial (
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Antifibrinolytics Tranexamic acid P
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Whole Blood/Components Storage and
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Plasma substitutes I: Short-term bl
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Plasma fractions for specific use H
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SECTION 10 CARDIOVASCULAR DRUGS DRU
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Drugs for Angina Dose : Oral : 10 m
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Drugs for Angina I : Angina pectori
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Lipid Lowering Drugs A/E: Reversibl
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Antihypertensive Drugs failure,neph
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Antihypertensive Drugs D/I: Arrhyth
Page 185 and 186: Antihypertensive Drugs Labetolol I:
Page 187 and 188: Antihypertensive Drugs Parenteral :
Page 189 and 190: Antihypertensive Drugs Mainly these
Page 191 and 192: Antihypertensive Drugs Alpha Methyl
Page 193 and 194: Antihypertensive Drugs Dose : In hy
Page 195 and 196: Drugs for Pulmonary Hypertension D/
Page 197 and 198: Drugs for Heart Failure Dopamine Do
Page 199 and 200: Anti Arrhythmic Drugs Dose: 250 - 5
Page 201 and 202: Anti Arrhythmic Drugs enzyme elevat
Page 203 and 204: Positive inotropic agents Dose : 2.
Page 205 and 206: Drugs for Superficial Mycosis P/A:
Page 207 and 208: Drugs for Deep Mycosis D/I: Increas
Page 209 and 210: Anti Bacterial for Topical Use P/C:
Page 211 and 212: Drugs used for Psoriasis Dithranol
Page 213 and 214: Drugs used for Warts P/C: Avoid use
Page 215 and 216: Drugs for other Dermatological Cond
Page 217 and 218: Drugs for other Dermatological Cond
Page 219 and 220: Drugs forLeprosy Rifampicin I: Lepr
Page 221 and 222: SECTION 12 DIAGNOSTIC AGENTS RADIOC
Page 223 and 224: Diagnostic agents A/E: Nausea, vomi
Page 225 and 226: Diagnostic agents reactions;hyperth
Page 227 and 228: SECTION 13 DISINFECTANTS AND ANTISE
Page 229 and 230: Disinfectants And Antiseptics ADMIN
Page 231 and 232: Disinfectants And Antiseptics Gluta
Page 233 and 234: Loop Diuretics P/A: Dose: Tablets 4
Page 235: Osmotic Diuretics D/I: Increases di
Page 239 and 240: Drugs for Dentistry STEROIDS Triamc
Page 241 and 242: Drugs for ENT A/E: P/A: Candidiasis
Page 243 and 244: Drugs for ENT C/I : Hypersensitivit
Page 245 and 246: Ulcer Healing Drugs mecamylamine,ps
Page 247 and 248: Antispasmodics syndrome. Lansoprazo
Page 249 and 250: Antiemetics And Prokinetics radioth
Page 251 and 252: Anti Diarrhoeals gastroenteritis an
Page 253 and 254: Laxatives osteomalacia; complete de
Page 255 and 256: Drugs Used In Inflammatory Bowel Di
Page 257 and 258: Drugs Used In Gall Stones and Heamo
Page 259 and 260: SECTION 18 HORMONES AND OTHER ENDOC
Page 261 and 262: Adrenal Hormones And Synthetic Subs
Page 263 and 264: Adrenal Hormones And Synthetic Subs
Page 265 and 266: Antiandrogens Ointment 2 % w/w, 5 %
Page 267 and 268: Oestrogens And AntiOestrogens A/E:
Page 269 and 270: Progestins And Antiprogestins A/E :
Page 271 and 272: Insulin and Other Anidiabetic Drugs
Page 273 and 274: Insulin and Other Anidiabetic Drugs
Page 275 and 276: Thyroid and Anit Thyroid Drugs Cost
Page 277 and 278: Vitamin D Derivatives orally. Anxie
Page 279 and 280: Bisphosphonates Dose: Hypercalcemia
Page 281 and 282: Sera and immunoglobulins Hypersensi
Page 283 and 284: Vaccines Hepatitis B Immunoglobulin
Page 285 and 286: Vaccines Dose: Primary immunization
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Vaccines Child:1-15 years: IM, 0.5
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SECTION 20 IMMUNOSUPPRESSANT DRUGS
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Cytotoxic drugs A/E: Hypersensitivi
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Glucocorticoids I : C/I: P/C : A/E:
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Drug treatment of Urolithiasis I: I
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Benign prostatic hypertrophy Terazo
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Urinary Frequency and Enuresis Dose
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Drugs For Impotence A/E : Penile pa
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SECTION 22 MUSCLE RELAXANTS AND ANT
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Central Muscle Relaxants Botulinum
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Peripheral Muscle Relaxant D/I: Sam
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Anticholinesterases C/I: P/C: A/E:
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SECTION 23 OPHTHALMOLOGICAL PREPARA
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Corticosteroids used in Ophthalmolo
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Drug used for Glaucoma Antagonists
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Nutritional Disorders affecting the
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Drugs and Pregnancy Drugs to be avo
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Oxytocics The drip is started with
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Drugs for Induction of Labour PROST
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Drugs for Vaginitis 2. Oral : fluco
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Drugs for Dysfunctional Uterine Ble
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SECTION 25 PSYCHOTHERAPEUTIC DRUGS
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Antipsychotic Drugs Fluphenazine Hy
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Antipsychotic Drugs start initially
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Antipsychotic Drugs dose upto 200 m
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Antipsychotic Drugs Discontinue, if
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Antidepressants reduction of effect
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Antidepressants Doxepin I: Depressi
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Antidepressants Citalopram I, A/E a
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Antidepressants P/C: Renal or hepat
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Anxiolytics C/I: P/C: A/E: P/A: Dos
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Anxiolytics Adjunct in acute alcoho
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Drugs used in substance dependence
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SECTION 26 PAEDIATRIC DRUGS AND NUT
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Paediatric drugs 333
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Paediatric drugs Medication >50 % 1
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Paediatric drugs Dicyclomine Hydroc
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Paediatric drugs Terbutaline A/E: T
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Paediatric drugs Amiodarone: A/E :
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Paediatric drugs STATINS Atorvastat
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Paediatric drugs Fosphenytoin P/A:
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Paediatric Nutrition NUTRITION Reco
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Paediatric Nutrition Daily requirem
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Paediatric Nutrition 6. Vitamin K M
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Paediatric Nutrition Calcium Calciu
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Paediatric Nutrition Combination wi
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Drugs for Respiratory Diseases P/A:
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Drugs for Upper Respiratory tract i
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Drugs for Tuberculosis headache, at
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Drugs for Tuberculosis several mont
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Drugs for Asthma and COPD may produ
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Drugs for Tuberculosis Dose: Etophy
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Drugs for Tuberculosis P/A: Inhaler
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Drugs for Tuberculosis Drugs availa
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Cough Suppressants and Mucolytics I
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SECTION 28 SOLUTIONS CORRECTING WAT
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Oral rehydration Salts I : P/C: A/E
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Parental Solutions mmol/litre in 24
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Parental Solutions oedema or water
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Parental Solutions I: pre- and peri
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Total Parental Nutritions solution
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Intravenous access device used for
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Intravenous access device advanced
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Forms of Intravenous Therapy Effect
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Forms of Intravenous Therapy Fluid
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Vitamins and Minerals severe, iodiz
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Vitamins and Minerals be precipitat
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Vitamins and Minerals CHILD 75-125
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Vitamins and Minerals INFANT under
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PART II GUIDELINES FOR FIRST LINE M
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General Topics pulmonary emergencie
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General Topics If the patient is sh
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General Topics DECONTAMINATION The
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General Topics should be monitored.
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General Topics 13. Benzodiazepines
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General Topics FIRST AID 1. Reassur
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General Topics When to repeat ASV A
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General Topics stings should be war
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Paediatrics Dose: 1 packet of ORS d
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Paediatrics 5. fatigue and exhausti
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Paediatrics RECUSCITATION OF NEWBOR
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Paediatrics neurological status. If
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CARDIOLOGY Evaluation of chest pain
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Cardiology ST segment elevation can
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Cardiology Contraindications for be
Page 461 and 462:
Cardiology Cardiac arrest and its m
Page 463 and 464:
Cardiology the procedure so that mo
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Cardiology Approach to treatment de
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Cardiology Adrenergic inhibitors La
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Respiratory System case crystalline
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Respiratory System 3. Acute Iaryngi
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Respiratory System PLEURAL EFFUSION
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Alimentary System comatose. Cardiac
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Alimentary System such as aluminium
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Endocrinology ‣ Tachycardia ‣ H
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Endocrinology Thyroid crisis can be
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NEUROLOGY COMA Coma is one of the m
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Neurology anticonvulsant action of
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OBSTETRICS AND GYNECOLOGY HYPEREMES
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Obstetrics and Gynecology Transfer
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Ophthalmology does not warrant any
Page 493 and 494:
PART III A. LIST OF ESSENTIAL DRUGS
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Primary Care Hospitals 7. ANTIEPILE
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Secondary Care Hospitals 23.IMMUNOL
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Secondary Care Hospitals 44 TERBUTA
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Secondary Care Hospitals 90 GLYCERI
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Taluk Hospitals 140 INSULIN BOVINE,
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Taluk Hospitals 33 METRONIDAZOLE IN
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Taluk Hospitals 7. ANTIDOTES AND OT
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Taluk Hospitals 126 DIGOXIN TAB IP
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Taluk Hospitals 176 DEXTROSE INJ IP
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Tertiary Hospitals 28.VITAMINS & MI
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Tertiary Hospitals 46 AZITHROMYCIN
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Tertiary Hospitals 7. ANTIDOTES AND
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Tertiary Hospitals 145 HEPARIN SODI
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Tertiary Hospitals 19. OPHTHALMIC D
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Tertiary Hospitals 249 HYDROGEN PER
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Tertiary Hospitals 303 FERROUS SULP
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Child Health 1. Progesterone only p
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Diarrhoea Control Programme end of
Page 531 and 532:
National Immunization Schedule 5. N
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National TB Control Programme DOTS
Page 535 and 536:
National Filaria Control Programme
Page 537 and 538:
APPENDIX 1 PREGNANCY During pregnan
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Alcuronium Amitriptyline Amoxyillin
Page 541 and 542:
Didanosine Diethylcarbamazine Doxyc
Page 543 and 544:
Magnesium sulfate Medroxyprogestero
Page 545 and 546:
methaemoglobinaemia; fear of increa
Page 547 and 548:
Table of medicines present in breas
Page 549 and 550:
Gentamicin Hydrochlorothiazide Insu
Page 551 and 552:
dose leaving the normal interval be
Page 553 and 554:
Benzathine penicillin Severe Neurot
Page 555 and 556:
elimination such as clearance and h
Page 557 and 558:
Heparin Hydralazine Hydrochlorothia
Page 559 and 560:
APPENDIX : 6 LIST OF EMERGENCY MEDI
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1. ANAESTHETICS 1.1. General anesth
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4.2. Specific Antisnake Venom U Inj
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Clarithromycin* S,T Capsules 500 mg
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6.4.2.3 Protease inhibitors Indinav
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Etoposide* T Capsules 100mg Injecti
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12. CARDIOVASCULAR MEDICINES 12.1.
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Provide Iodine U Solution or Ointme
Page 575 and 576:
17.2 Antiemetics Domperidone U Tabl
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Norethisterone U Tablets 5 mg 18.8
Page 579 and 580:
Methyl Ergometrine U Tablets 0.125m
Page 581 and 582:
Calcium salts U Tablets 250,500 mg
Page 583 and 584:
Drugs Minimum Maximum Rifampicin 45
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54. Fixed dose combination of Analg
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APPENDIX 8 ADVERSE DRUG EVENT REPOR
Page 589 and 590:
Amiloride .........................
Page 591 and 592:
Bromhexine ........................
Page 593 and 594:
Conjugated oestrogen ..............
Page 595 and 596:
Esmolol ...........................
Page 597 and 598:
Hydrochlorothiazide ...............
Page 599 and 600:
Loxapine ..........................
Page 601 and 602:
Nitrous Oxide .....................
Page 603 and 604:
Povidone iodine ...................
Page 605 and 606:
Sodium Thiosulphate ...............
Page 607:
Vaccines ..........................
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