Kerala State Drug Formulary.pdf

Antimalarial drugs
Quinine
I: Acts on mature trophozoites of all species of
plasmodium; nocturnal leg cramps
C/l: Hypersensitivity, G6PD deficiency, pregnancy, lactation.
P/C: Use with caution in chronic renal dysfunction, optic
neuritis, myasthenia gravis, cardiac dysfunction
A/E: Cinchonism - tinnitus, nausea, headache and disturbed
vision, Gl symptoms, angioedema, hyperinsulinemic
hypoglycemia,excitement,delirium, thrombocytopenia,
agranulocytosis, hypotension, muscle paralysis in
myasthenic patients.
P/A: Tablet 100 mg, , 300 mg,
Injection 300 mg/ mL .
Dose: 300 - 600 mg tds. for 5 - 7 days.
IV loading dose 20mg/kg max to 1.4g infused over 4h
Maintenance dose 10mg/kg max 700mg infused over 4
hours every 8 to 12 hours until patient can swallow
tablets to complete 7 day course (5to 7 mg/kg if the
IV therapy is beyond 48 hours)
D/I: Blood levels of digoxin increased, hypoprothrombinemic
effect of warfarin enhanced, hypoglycemic effect of
oral antidiabetics enhanced.
Cost: Tab 300 mg (10) Rs. 35.00 - 60.00
Injection 300 mg/mL (2 mL) Rs. 11.00 -19.00
ANTIAMOEBIC AND OTHER PROTOZOAL DRUGS
ANTIAMOEBIC DRUGS
Metronidazole
l: Amoebiasis, giardiasis, trichomonal vaginitis, anaerobic
infections, ulcerative gingivitis, trench mouth, guinea
worm infestation, H.pylori infection, Vincent’s angina,
pseudomembraneous colitis by C.difficile, Bacteriodes
fragilis infection.
C/l: Neurological disease, blood dyscrasias, first trimester
of pregnancy. Though no teratogenic effect has yet been
demonstrated, its mutagenic potential warrants
caution.
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