Kerala State Drug Formulary.pdf

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CENTRAL DRUG FORMULARY COMMITTEE CHAIRMAN : Dr. K.V. KRISHNADAS, B.Sc., MBBS, FRCP, FAMS, DTM & H, Director and Professor of Medicine and Vice Principal (Retd.) Government Medical College, Thiruvananthapuram. CONVENOR : Dr. RENEEGA GANGADHAR, M.D. Professor & Head, Department of Pharmacology Government Medical College, Thiruvananthapuram. MEMBERS : 1. Dr. V. Geetha, Director of Medical Education. 2. Dr. Shylaja, Director of Health Services 3. Dr. C. Sudheendra Ghosh, Joint Director of Medical Education. 4. Dr. Ramdas Pisharody, Principal, Government Medical College, Thiruvananthapuram. 5. Dr. B Jayakumar, Professor & Head, Department of Medicine, Government Medical College, Thiruvananthapuram. 6. Dr. Lalitha Kailas, Professor & Head, Department of Paediatrics, Government Medical College, Thiruvananthapuram. 7. Dr. Abdul Salim, Professor & Head of Surgery, Government Medical College, Thiruvananthapuram. 8. Dr. Ramani P.T., Professor of Pharmacology, Government Medical College, Thiruvananthapuram. 9. Dr. Raymond Morris, Professor & Head, Department of Neurosurgery, Government Medical College, Thiruvananthapuram. iii
10. Dr. C.P. Vijayan, Professor of O & G, Government Medical College, Kottayam. 11. Dr. Thomas Mathew, Professor & Head, Department of Community Medicine, Government Medical College, Alappuzha. 12. Dr. Krishnan Namboodhiri, Professor & Head, Department of Cardiology, Government Medical College, Kozhikode. 13. Dr. Joyamma, Professor of Pharmacology, College of Pharmaceutical Sciences, Government Medical College, Thiruvananthapuram. SCIENTIFIC ASSISTANTS 1. Dr. Dhanya T.H., Department of Pharmacology, Government Medical College, Thiruvananthapuram. 2. Dr. Gayathri M Kapse, Department of Pharmacology, Government Medical College, Thiruvananthapuram. 3. Dr. Jesitha Jayaraj, Department of Pharmacology, Government Medical College, Thiruvananthapuram. COMPUTER PROGRAMMERS 1. Dr. Deepu Jacob Chacko, Department of Pharmacology, Government Medical College, Thiruvananthapuram. 2. Dr. Amal Abraham Mathew, Department of Pharmacology, Government Medical College, Thiruvananthapuram. 3. Mr. Rethna Senan, Department of Pharmacology, Government Medical College, Thiruvananthapuram. iv
Page 2 and 3: KERALA STATE DRUG FORMULARY NUMBER
Page 6 and 7: LIST OF CONTRIBUTORS 1. Dr. K.V. Kr
Page 8 and 9: FOREWORD Medicines play a crucial r
Page 10 and 11: Dr. V. Geetha, Director of Medical
Page 12 and 13: ABBREVIATIONS A/E .................
Page 14 and 15: Antiretroviral drugs ..............
Page 16 and 17: Dyes used in ophthalmology ........
Page 18 and 19: Antipsychotic drugs ...............
Page 20 and 21: Eclampsia .........................
Page 23 and 24: PART - I GENERAL ADVICE TO PRESCRIB
Page 25 and 26: General advice to Prescribers Monit
Page 27 and 28: General advice to Prescribers Pharm
Page 29 and 30: General advice to Prescribers refil
Page 31 and 32: General advice to Prescribers neces
Page 33 and 34: General advice to Prescribers 2C19
Page 35 and 36: General advice to Prescribers possi
Page 37 and 38: General advice to Prescribers Cost
Page 39 and 40: General advice to Prescribers Did w
Page 41 and 42: Inhalational agents I:, C/I:,D/I: s
Page 43 and 44: Intravenous General Anaesthetics Re
Page 45 and 46: Local Anaesthetics anaesthesia. Low
Page 47 and 48: Local Anaesthetics A/E: P/A: Dose:
Page 49 and 50: Preoperative Medication PREOPERATIV
Page 51 and 52: Preoperative Medication A/E: P/A: D
Page 53 and 54: SECTION - 2 ANALGESICS, ANTIPYRETIC
Page 55 and 56:
Non-Steroidal Anti-Inflammatory Dru
Page 57 and 58:
Page 59 and 60:
Page 61 and 62:
Opioid Analgesics P/A : Injection:
Page 63 and 64:
Opioid Analgesics pain, 100 mg init
Page 65 and 66:
Drugs in Rheumatoid Disorders P/A:
Page 67 and 68:
Drugs in Rheumatoid Disorders IMPOR
Page 69 and 70:
Medicines used for Gout Dose: Admin
Page 71 and 72:
SECTION - 3 ANTI CONVULSANTS/ANTIEP
Page 73 and 74:
Antiepileptics A/E: Cardiovascular
Page 75 and 76:
Antiepileptics Ethosuximide I: Drug
Page 77 and 78:
Antiepileptics hypotonia, coordinat
Page 79 and 80:
Antiepileptics Topiramate I: Adjunc
Page 81 and 82:
Antiepileptics Felbamate I: Unrespo
Page 83 and 84:
SECTION - 4 ANTIINFECTIVE DRUGS ANT
Page 85 and 86:
Pencillins Phenoxymethyl penicillin
Page 87 and 88:
Cephalosporins Cephazolin I: Surgic
Page 89 and 90:
Pencillins Cefdinir I: Pneumonia, c
Page 91 and 92:
Aminoglycosides Gentamicin I: Urina
Page 93 and 94:
Broad spectrum antibiotics I: Ricke
Page 95 and 96:
Macrolides pertussis, endemic trach
Page 97 and 98:
Macrolides photosensitivity; hepati
Page 99 and 100:
Teicoplanin Cost: Tab 50 mg (10) Rs
Page 101 and 102:
Fluoroquinolones A/E: Nausea, epiga
Page 103 and 104:
Sulphonamides A/E: same as in cipro
Page 105 and 106:
Antifungal drugs Sulphacetamide I:
Page 107 and 108:
Antiviral drugs ANTI VIRAL DRUGS An
Page 109 and 110:
Non selective antiviral drugs Dose:
Page 111 and 112:
Antiretroviral drugs Dose: Oral, 30
Page 113 and 114:
Antiretroviral drugs A/E : Rash inc
Page 115 and 116:
Antimalarial drugs Artesunate I: Ml
Page 117 and 118:
Antimalarial drugs Quinine I: Acts
Page 119 and 120:
Antiamoebic and other protozoal dru
Page 121 and 122:
Anthelmintics drugs Other drugs use
Page 123 and 124:
Antifilarial drugs SCHISTOSOMICIDES
Page 125 and 126:
SECTION - 5 ANTIMIGRAINE MEDICINES
Page 127 and 128:
SECTION 6 ANTINEOPLASTIC DRUGS ALKY
Page 129 and 130:
Antimetabolites Cost : Inj: 1 g via
Page 131 and 132:
Antineoplastic Drugs Cost : 5-Fluor
Page 133 and 134:
Cytotoxis Antibiotics P/A: Injectio
Page 135 and 136:
Mitotic Inhibitors Epirubicin I: Ca
Page 137 and 138:
Hormones and Hormonal antagonists P
Page 139 and 140:
Targeted agents Progestins Medroxy
Page 141 and 142:
Cytoprotective agents A/E: Infusion
Page 143 and 144:
Dopaminergic agonist P/A: Dose: Bro
Page 145 and 146:
MAO B Inhibitor MAO B Inhibitor Sel
Page 147 and 148:
Central Anticholinergics daily (wit
Page 149 and 150:
SECTION - 8 DRUGS ACTING ON BLOOD A
Page 151 and 152:
Drug affecting Coagulation P/C: Can
Page 153 and 154:
Haemolytic Anaemias HAEMOLYTIC ANAE
Page 155 and 156:
Iron chelating drugs iron, aluminiu
Page 157 and 158:
Acute Myelogenous Leukemia (All Tra
Page 159 and 160:
Chronic Lymphocytic Leukemia dyspne
Page 161 and 162:
Antiplatelet drugs Dose: 300 mg in
Page 163 and 164:
Thrombolytic drugs Cost: lnj vial (
Page 165 and 166:
Antifibrinolytics Tranexamic acid P
Page 167 and 168:
Whole Blood/Components Storage and
Page 169 and 170:
Plasma substitutes I: Short-term bl
Page 171 and 172:
Plasma fractions for specific use H
Page 173 and 174:
SECTION 10 CARDIOVASCULAR DRUGS DRU
Page 175 and 176:
Drugs for Angina Dose : Oral : 10 m
Page 177 and 178:
Drugs for Angina I : Angina pectori
Page 179 and 180:
Lipid Lowering Drugs A/E: Reversibl
Page 181 and 182:
Antihypertensive Drugs failure,neph
Page 183 and 184:
Antihypertensive Drugs D/I: Arrhyth
Page 185 and 186:
Antihypertensive Drugs Labetolol I:
Page 187 and 188:
Antihypertensive Drugs Parenteral :
Page 189 and 190:
Antihypertensive Drugs Mainly these
Page 191 and 192:
Antihypertensive Drugs Alpha Methyl
Page 193 and 194:
Antihypertensive Drugs Dose : In hy
Page 195 and 196:
Drugs for Pulmonary Hypertension D/
Page 197 and 198:
Drugs for Heart Failure Dopamine Do
Page 199 and 200:
Anti Arrhythmic Drugs Dose: 250 - 5
Page 201 and 202:
Anti Arrhythmic Drugs enzyme elevat
Page 203 and 204:
Positive inotropic agents Dose : 2.
Page 205 and 206:
Drugs for Superficial Mycosis P/A:
Page 207 and 208:
Drugs for Deep Mycosis D/I: Increas
Page 209 and 210:
Anti Bacterial for Topical Use P/C:
Page 211 and 212:
Drugs used for Psoriasis Dithranol
Page 213 and 214:
Drugs used for Warts P/C: Avoid use
Page 215 and 216:
Drugs for other Dermatological Cond
Page 217 and 218:
Drugs for other Dermatological Cond
Page 219 and 220:
Drugs forLeprosy Rifampicin I: Lepr
Page 221 and 222:
SECTION 12 DIAGNOSTIC AGENTS RADIOC
Page 223 and 224:
Diagnostic agents A/E: Nausea, vomi
Page 225 and 226:
Diagnostic agents reactions;hyperth
Page 227 and 228:
SECTION 13 DISINFECTANTS AND ANTISE
Page 229 and 230:
Disinfectants And Antiseptics ADMIN
Page 231 and 232:
Disinfectants And Antiseptics Gluta
Page 233 and 234:
Loop Diuretics P/A: Dose: Tablets 4
Page 235 and 236:
Osmotic Diuretics D/I: Increases di
Page 237 and 238:
SECTION 15 DRUGS USED IN DENTISTRY
Page 239 and 240:
Drugs for Dentistry STEROIDS Triamc
Page 241 and 242:
Drugs for ENT A/E: P/A: Candidiasis
Page 243 and 244:
Drugs for ENT C/I : Hypersensitivit
Page 245 and 246:
Ulcer Healing Drugs mecamylamine,ps
Page 247 and 248:
Antispasmodics syndrome. Lansoprazo
Page 249 and 250:
Antiemetics And Prokinetics radioth
Page 251 and 252:
Anti Diarrhoeals gastroenteritis an
Page 253 and 254:
Laxatives osteomalacia; complete de
Page 255 and 256:
Drugs Used In Inflammatory Bowel Di
Page 257 and 258:
Drugs Used In Gall Stones and Heamo
Page 259 and 260:
SECTION 18 HORMONES AND OTHER ENDOC
Page 261 and 262:
Adrenal Hormones And Synthetic Subs
Page 263 and 264:
Adrenal Hormones And Synthetic Subs
Page 265 and 266:
Antiandrogens Ointment 2 % w/w, 5 %
Page 267 and 268:
Oestrogens And AntiOestrogens A/E:
Page 269 and 270:
Progestins And Antiprogestins A/E :
Page 271 and 272:
Insulin and Other Anidiabetic Drugs
Page 273 and 274:
Insulin and Other Anidiabetic Drugs
Page 275 and 276:
Thyroid and Anit Thyroid Drugs Cost
Page 277 and 278:
Vitamin D Derivatives orally. Anxie
Page 279 and 280:
Bisphosphonates Dose: Hypercalcemia
Page 281 and 282:
Sera and immunoglobulins Hypersensi
Page 283 and 284:
Vaccines Hepatitis B Immunoglobulin
Page 285 and 286:
Vaccines Dose: Primary immunization
Page 287 and 288:
Vaccines Child:1-15 years: IM, 0.5
Page 289 and 290:
SECTION 20 IMMUNOSUPPRESSANT DRUGS
Page 291 and 292:
Cytotoxic drugs A/E: Hypersensitivi
Page 293 and 294:
Glucocorticoids I : C/I: P/C : A/E:
Page 295 and 296:
Drug treatment of Urolithiasis I: I
Page 297 and 298:
Benign prostatic hypertrophy Terazo
Page 299 and 300:
Urinary Frequency and Enuresis Dose
Page 301 and 302:
Drugs For Impotence A/E : Penile pa
Page 303 and 304:
SECTION 22 MUSCLE RELAXANTS AND ANT
Page 305 and 306:
Central Muscle Relaxants Botulinum
Page 307 and 308:
Peripheral Muscle Relaxant D/I: Sam
Page 309 and 310:
Anticholinesterases C/I: P/C: A/E:
Page 311 and 312:
SECTION 23 OPHTHALMOLOGICAL PREPARA
Page 313 and 314:
Corticosteroids used in Ophthalmolo
Page 315 and 316:
Drug used for Glaucoma Antagonists
Page 317 and 318:
Nutritional Disorders affecting the
Page 319 and 320:
Drugs and Pregnancy Drugs to be avo
Page 321 and 322:
Oxytocics The drip is started with
Page 323 and 324:
Drugs for Induction of Labour PROST
Page 325 and 326:
Drugs for Vaginitis 2. Oral : fluco
Page 327 and 328:
Drugs for Dysfunctional Uterine Ble
Page 329 and 330:
SECTION 25 PSYCHOTHERAPEUTIC DRUGS
Page 331 and 332:
Antipsychotic Drugs Fluphenazine Hy
Page 333 and 334:
Antipsychotic Drugs start initially
Page 335 and 336:
Antipsychotic Drugs dose upto 200 m
Page 337 and 338:
Antipsychotic Drugs Discontinue, if
Page 339 and 340:
Antidepressants reduction of effect
Page 341 and 342:
Antidepressants Doxepin I: Depressi
Page 343 and 344:
Antidepressants Citalopram I, A/E a
Page 345 and 346:
Antidepressants P/C: Renal or hepat
Page 347 and 348:
Anxiolytics C/I: P/C: A/E: P/A: Dos
Page 349 and 350:
Anxiolytics Adjunct in acute alcoho
Page 351 and 352:
Drugs used in substance dependence
Page 353 and 354:
SECTION 26 PAEDIATRIC DRUGS AND NUT
Page 355 and 356:
Paediatric drugs 333
Page 357 and 358:
Page 359 and 360:
Page 361 and 362:
Paediatric drugs Medication >50 % 1
Page 363 and 364:
Paediatric drugs Dicyclomine Hydroc
Page 365 and 366:
Paediatric drugs Terbutaline A/E: T
Page 367 and 368:
Paediatric drugs Amiodarone: A/E :
Page 369 and 370:
Paediatric drugs STATINS Atorvastat
Page 371 and 372:
Paediatric drugs Fosphenytoin P/A:
Page 373 and 374:
Paediatric Nutrition NUTRITION Reco
Page 375 and 376:
Paediatric Nutrition Daily requirem
Page 377 and 378:
Paediatric Nutrition 6. Vitamin K M
Page 379 and 380:
Paediatric Nutrition Calcium Calciu
Page 381 and 382:
Paediatric Nutrition Combination wi
Page 383 and 384:
Drugs for Respiratory Diseases P/A:
Page 385 and 386:
Drugs for Upper Respiratory tract i
Page 387 and 388:
Drugs for Tuberculosis headache, at
Page 389 and 390:
Drugs for Tuberculosis several mont
Page 391 and 392:
Drugs for Asthma and COPD may produ
Page 393 and 394:
Drugs for Tuberculosis Dose: Etophy
Page 395 and 396:
Drugs for Tuberculosis P/A: Inhaler
Page 397 and 398:
Drugs for Tuberculosis Drugs availa
Page 399 and 400:
Cough Suppressants and Mucolytics I
Page 401 and 402:
SECTION 28 SOLUTIONS CORRECTING WAT
Page 403 and 404:
Oral rehydration Salts I : P/C: A/E
Page 405 and 406:
Parental Solutions mmol/litre in 24
Page 407 and 408:
Parental Solutions oedema or water
Page 409 and 410:
Parental Solutions I: pre- and peri
Page 411 and 412:
Total Parental Nutritions solution
Page 413 and 414:
Intravenous access device used for
Page 415 and 416:
Intravenous access device advanced
Page 417 and 418:
Forms of Intravenous Therapy Effect
Page 419 and 420:
Forms of Intravenous Therapy Fluid
Page 421 and 422:
Vitamins and Minerals severe, iodiz
Page 423 and 424:
Vitamins and Minerals be precipitat
Page 425 and 426:
Vitamins and Minerals CHILD 75-125
Page 427 and 428:
Vitamins and Minerals INFANT under
Page 429 and 430:
PART II GUIDELINES FOR FIRST LINE M
Page 431 and 432:
General Topics pulmonary emergencie
Page 433 and 434:
General Topics If the patient is sh
Page 435 and 436:
General Topics DECONTAMINATION The
Page 437 and 438:
General Topics should be monitored.
Page 439 and 440:
General Topics 13. Benzodiazepines
Page 441 and 442:
General Topics FIRST AID 1. Reassur
Page 443 and 444:
General Topics When to repeat ASV A
Page 445 and 446:
General Topics stings should be war
Page 447 and 448:
Paediatrics Dose: 1 packet of ORS d
Page 449 and 450:
Paediatrics 5. fatigue and exhausti
Page 451 and 452:
Paediatrics RECUSCITATION OF NEWBOR
Page 453 and 454:
Paediatrics neurological status. If
Page 455 and 456:
CARDIOLOGY Evaluation of chest pain
Page 457 and 458:
Cardiology ST segment elevation can
Page 459 and 460:
Cardiology Contraindications for be
Page 461 and 462:
Cardiology Cardiac arrest and its m
Page 463 and 464:
Cardiology the procedure so that mo
Page 465 and 466:
Cardiology Approach to treatment de
Page 467 and 468:
Cardiology Adrenergic inhibitors La
Page 469 and 470:
Respiratory System case crystalline
Page 471 and 472:
Respiratory System 3. Acute Iaryngi
Page 473 and 474:
Respiratory System PLEURAL EFFUSION
Page 475 and 476:
Alimentary System comatose. Cardiac
Page 477 and 478:
Alimentary System such as aluminium
Page 479 and 480:
Endocrinology ‣ Tachycardia ‣ H
Page 481 and 482:
Endocrinology Thyroid crisis can be
Page 483 and 484:
NEUROLOGY COMA Coma is one of the m
Page 485 and 486:
Neurology anticonvulsant action of
Page 487 and 488:
OBSTETRICS AND GYNECOLOGY HYPEREMES
Page 489 and 490:
Obstetrics and Gynecology Transfer
Page 491 and 492:
Ophthalmology does not warrant any
Page 493 and 494:
PART III A. LIST OF ESSENTIAL DRUGS
Page 495 and 496:
Primary Care Hospitals 7. ANTIEPILE
Page 497 and 498:
Secondary Care Hospitals 23.IMMUNOL
Page 499 and 500:
Secondary Care Hospitals 44 TERBUTA
Page 501 and 502:
Secondary Care Hospitals 90 GLYCERI
Page 503 and 504:
Taluk Hospitals 140 INSULIN BOVINE,
Page 505 and 506:
Taluk Hospitals 33 METRONIDAZOLE IN
Page 507 and 508:
Taluk Hospitals 7. ANTIDOTES AND OT
Page 509 and 510:
Taluk Hospitals 126 DIGOXIN TAB IP
Page 511 and 512:
Taluk Hospitals 176 DEXTROSE INJ IP
Page 513 and 514:
Tertiary Hospitals 28.VITAMINS & MI
Page 515 and 516:
Tertiary Hospitals 46 AZITHROMYCIN
Page 517 and 518:
Tertiary Hospitals 7. ANTIDOTES AND
Page 519 and 520:
Tertiary Hospitals 145 HEPARIN SODI
Page 521 and 522:
Tertiary Hospitals 19. OPHTHALMIC D
Page 523 and 524:
Tertiary Hospitals 249 HYDROGEN PER
Page 525 and 526:
Tertiary Hospitals 303 FERROUS SULP
Page 527 and 528:
Child Health 1. Progesterone only p
Page 529 and 530:
Diarrhoea Control Programme end of
Page 531 and 532:
National Immunization Schedule 5. N
Page 533 and 534:
National TB Control Programme DOTS
Page 535 and 536:
National Filaria Control Programme
Page 537 and 538:
APPENDIX 1 PREGNANCY During pregnan
Page 539 and 540:
Alcuronium Amitriptyline Amoxyillin
Page 541 and 542:
Didanosine Diethylcarbamazine Doxyc
Page 543 and 544:
Magnesium sulfate Medroxyprogestero
Page 545 and 546:
methaemoglobinaemia; fear of increa
Page 547 and 548:
Table of medicines present in breas
Page 549 and 550:
Gentamicin Hydrochlorothiazide Insu
Page 551 and 552:
dose leaving the normal interval be
Page 553 and 554:
Benzathine penicillin Severe Neurot
Page 555 and 556:
elimination such as clearance and h
Page 557 and 558:
Heparin Hydralazine Hydrochlorothia
Page 559 and 560:
APPENDIX : 6 LIST OF EMERGENCY MEDI
Page 561 and 562:
1. ANAESTHETICS 1.1. General anesth
Page 563 and 564:
4.2. Specific Antisnake Venom U Inj
Page 565 and 566:
Clarithromycin* S,T Capsules 500 mg
Page 567 and 568:
6.4.2.3 Protease inhibitors Indinav
Page 569 and 570:
Etoposide* T Capsules 100mg Injecti
Page 571 and 572:
12. CARDIOVASCULAR MEDICINES 12.1.
Page 573 and 574:
Provide Iodine U Solution or Ointme
Page 575 and 576:
17.2 Antiemetics Domperidone U Tabl
Page 577 and 578:
Norethisterone U Tablets 5 mg 18.8
Page 579 and 580:
Methyl Ergometrine U Tablets 0.125m
Page 581 and 582:
Calcium salts U Tablets 250,500 mg
Page 583 and 584:
Drugs Minimum Maximum Rifampicin 45
Page 585 and 586:
54. Fixed dose combination of Analg
Page 587 and 588:
APPENDIX 8 ADVERSE DRUG EVENT REPOR
Page 589 and 590:
Amiloride .........................
Page 591 and 592:
Bromhexine ........................
Page 593 and 594:
Conjugated oestrogen ..............
Page 595 and 596:
Esmolol ...........................
Page 597 and 598:
Hydrochlorothiazide ...............
Page 599 and 600:
Loxapine ..........................
Page 601 and 602:
Nitrous Oxide .....................
Page 603 and 604:
Povidone iodine ...................
Page 605 and 606:
Sodium Thiosulphate ...............
Page 607:
Vaccines ..........................
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