Kerala State Drug Formulary.pdf

Drugs Used In Gall Stones and Heamorrhoids
C/I:
P/C:
A/E:
Dose:
Untreated chronic infection TB, Moderate to severe
congestive cardiac failure, known hypersensitivity to
murine proteins or any other component of the drugs.
Mild heart failure, seizures, Renal or hepatic failure,
Pregnancy and breast feeding.
Infection, fever, fatigue, muscle weakness
agranulocytosis, hypersensitivity, lupus like symptoms,
steven Johnson syndrome, toxic epidermal necrolysis.
Infliximab is administered as a single dose for fistulizing
crohn’s disease, the dose is 5 mg/kg followed by
additional doses of 5 mg/kg two and six week after the
first dose.
DRUGS USED IN GALL STONES
Chenodeoxycholic acid
I: Gallstone disease.
C/l: Pregnancy, lactation, hypersensitivity, atherosclerosis,
biliary cirrhosis, pancreatitis, cholecysti tis, hepatic
impairment.
P/C ; Determination of hepatic function and ultrasonogram
is advised prior to treatment. Serum cholesterol
concentration determination recommended at 6 month
interval during therapy.
A/E: Diarrhoea, indigestion, loss of appetite, nausea,
vomiting, stomach cramps.
P/A : Capsule 250 mg
Dose : 250 mg/day taken with food or milk in the morning and
at night.
D/I : Antacids, colestipol, cholestyramine decrease the
absorption of the drug. Clofibrate, oestrogens,
neomycin or progestins increase cholesterol saturation
of bile thereby decrease the effect of chenodeoxycholic
acid.
Cost : Tab 250 mg (10) Rs. 85.00 — 90.00
Ursodeoxycholic acid
I: Gallstone disease, biliary cirrhosis, chronic hepatitis
and cystic fibrosis.
C/I: P/C :A/E :D/I: Same as for chenodeoxycholic acid.
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