Kerala State Drug Formulary.pdf

Antiepileptics
56
P/A:
Dose:
D/I :
Tablets 25 mg, 100 mg, 150 mg, 200 mg.
Starting dose of 25 mg hs. increasing in 25 mg/ day
increments at 2 week intervals to a maximum of 100
mg/day.
Valproic acid blocks the elimination of lamotrigine.
Cost : Tab 25 mg (10) Rs. 33.00
Gabapentin
I: Adjunctive treatment of partial seizures with or without
secondary generalisation not satisfactorily controlled
with other antiepileptics.
C/I: Hypersensitivity
P/C: Avoid sudden withdrawal. The drug should be tapered
off over at least 1 week.
A/E: Somnolence, dizziness, ataxia, tremor, diplopia, nausea
and vomiting, also convulsions.
P/A: Capsule 300 mg and 400 mg.
Dose: 300 mg on first day, then 300 mg bd on second day,
then 300 mg tds. on third day, then increased according
to response to 1.2 g daily (in 3 equally divided doses).
Not recommended for children.
D/I: Reduced absorption with antacids;
Cost : Caps 300 mg (10) Rs. 98.50 – 313.00
Vigabatrin
I: Simple and complex pastial seizures; generalised
seizures.
C/I: Pregnancy and breast feeding
P/C: Renal impairment, closely monitor neurological
functions, avoid sudden withdrawal.
A/E: Mild, drowsiness, mental confusion, amnesia,
behavioural changes and agitation in children.
P/A: Tablet 500mg
Dose: With current antiepileptic therapy, initially 1 g daily
in single or 2 divided doses, then increased according
to response in steps of 500mg; usual range 2-4 g
daily.
D/I: Causes a 20% decrease in plasma phenytoin
concentration.