Kerala State Drug Formulary.pdf

Drugs for Pulmonary Hypertension
D/I: Diuretics and other antihypertensives potentiate the
action of losartan, risk of hyperkalaemia with potassium
sparing diuretics. NSAIDs may blunt hypotensive effect
of losartan .
Cost: Tab 25 mg (10) Rs, 40.00
Newer drugs in this class include—Telmisartan, Valsartan, Olmisartan,
Candesartan , Irbesartan
DRUGS USED IN PULMONARY HYPERTENSION
Bosentan
Bosentan is the first of a new drug class, an endothelin receptor
antagonist.
I: Pulmonary arterial hypertension
C/I: Pregnancy, hypersensitivity
P/C: May cause elevation of AST/ALT and bilirubin,
A/E: Hypersensitivity, Rash Thrombocytopenia, headache,
palpitations, edema, abnormal LFTs
P/A: 62.5 mg and 125 mg tablets
Dose: initiated at a dose of 62.5 mg bid and then increased
to the maintenance dose of 125 mg bid.
Sildenafil
selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific
phosphodiesterase type-5 (PDE5).
I: pulmonary arterial hypertension, male erectile
dysfunction
C/I: co administration to patients on organic nitrates is
contraindicated due to hypotensive effects
P/C: patients with resting hypotension (BP