Kerala State Drug Formulary.pdf

Non-Steroidal Anti-Inflammatory Drugs
Mefenamic acid
I: Mild to moderate pain, dysmenorrhoea , menorrhagia,
osteoarthritis, rheumatoid arthritis, juvenile arthritis
C/I: Active peptic ulcer.history of GI lesion, pregnancy,
lactation
A/E: Similar to Ibuprofen
P/A: Tablets,250mg,500mg
Dose: Adult, oral 500mg three times daily,after food
Cost: 250mg (10) Rs10-16/-
Aceclofenac
I: Pain and inflammation in rheumatoid arthritis,
osteoarthritis a ankylosing spondylitis.
C/I: Asthma, angioedema, urticaria or rhinitis, pregnancy,
breastfeeding severe congestive heart failure, history
of cardiac failure, left ventricular dysfunction,
hypertension, oedema, active peptic ulceration.
P/C: Elderly, allergic disorders; renal, cardiac or hepatic
impairment;avoid in porphyria.
A/E : GI discomfort, nausea, diarrhoea, occasionally bleeding
and ulceration;hypersensitivity reactions, headache,
dizziness, nervousness, depression drowsiness,
insomnia, vertigo, hearing disturbances such as tinnitus
photosensitivity and haematuria; blood disorders; fluid
retention; blood pressure may be raised; rarely papillary
necrosis or interstitial fibrosis hepatic damage,
alveolitis, pulmonary eosinophilia, pancreatitis,eye
changes, Stevens-Johnson syndrome and toxic
epidermal necrolysis, Induction of or exacerbation of
colitis has been reported.
P/A: Tablet, 100 mg.
Dose: ADULT: Oral, 100 mg twice daily. (reduce to 100 mg
daily, initially in hepatic impairment).CHILD:Not
recommended.
Cost: 100mg (10) Rs16.25-20/-
Etoricoxib
I: Pain and inflammation in osteoarthritis and in
rheumatoid arthritis; acute gout.
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