Kerala State Drug Formulary.pdf

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Antiinfective <strong>Drug</strong>s Cost: Benzyl penicillin lnjection 10 lac units (vial) Rs. 7.00 - 8.00 Benzathine penicillin I: Pharyngitis,Prophylaxis of Rheumatic Fever,Syphilis C/I: As for Benzyl Penicillin,should not inject intravascularly P/C: As for Benzyl Penicillin,not recommended in neurosyphilis due to its inadequate penetration into CSF. A/E: As for Benzyl Penicillin P/A: Injection 600,000 and 1,200,000 units/vial (powder for reconstitution) Note: 900 mg Benzathine penicillin is approximately equivalent to 720 mg of Benzyl Penicillin(1.2 million units) Dose: Adult Rheumatic fever 12 lakh units (900 mg) deep IM repeated every 3-4 weeks Syphilis:24 lakh units 1.8 g deep IM at weekly intervals for 3 consecutive weeks. Child:
Pencillins Phenoxymethyl penicillin (Penicillin V) Dose: 500 mg every 6 hours orally,increase upto 750 mg in severe infections. Cost: 250 mg (10) Rs:13.50/- Beta lactamase resistant penicillins Cloxacillin I: Infections due to penicillinase resistant staphylococci C/I: P/C: A/E: D/I: Similar to that of Benzyl penicillin P/A: Capsules 250 mg, 500 mg, Injection 250 mg, 500 mg(Powder for reconstitution) Combination preparations (tablet, injection, syrup) with ampicillin in different ratios are available. Dose: 250-500 mg orally 4 times daily half an hour before food;250 mg IM every 4-6 hours;500 mg slow IV every 4-6 hours. Cost: Caps 500 mg (10) Rs. 63.00; Injection 250 mg (1 vial) Rs. 6.00 -10.00 Broad spectrum penicillins Spectrum of Penicillin G + activity against g –ve bacteria Ampicillin I: Urinary tract infection, respiratory tract infections,otitis media,sinusitis,chronic bronchitis, invasive salmonellosis and gonorrhea. C/l: Penicillin hypersensitivity P/C: D/I: As for of benzyl penicillin. A/E: As for of benzyl penicillin;nausea,diarrhoea,rashes P/A: Capsules 250 mg, 500 mg Injection 500 mg/vial (Powder for reconstitution) Dose : 250 mg-1 g 6 hourly atleast 30 minutes before or 2 hours after food;500 mg IM/slow IV every 4-6 hours Cost: Caps 250mg (10) Rs. 32.00 - 36.00 Injection 500 mg (vial) Rs.10.00 - 23.00 Ampicillin + Sulbactam I: Infections caused by beta lactamase producing organisms P/A: Injection Ampicillin1g + Sulbactam 0.5g Dose: 1.5 – 3 g IV/deep IM 6-8 hourly Cost: Injection Ampicillin1g + Sulbactam 0.5g vial Rs. 78.00 – 110.00 63
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KERALA STATE DRUG FORMULARY NUMBER
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CENTRAL DRUG FORMULARY COMMITTEE CH
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LIST OF CONTRIBUTORS 1. Dr. K.V. Kr
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FOREWORD Medicines play a crucial r
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Dr. V. Geetha, Director of Medical
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ABBREVIATIONS A/E .................
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Antiretroviral drugs ..............
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Dyes used in ophthalmology ........
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Antipsychotic drugs ...............
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Eclampsia .........................
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PART - I GENERAL ADVICE TO PRESCRIB
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General advice to Prescribers Monit
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General advice to Prescribers Pharm
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General advice to Prescribers refil
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General advice to Prescribers neces
Page 33 and 34: General advice to Prescribers 2C19
Page 35 and 36: General advice to Prescribers possi
Page 37 and 38: General advice to Prescribers Cost
Page 39 and 40: General advice to Prescribers Did w
Page 41 and 42: Inhalational agents I:, C/I:,D/I: s
Page 43 and 44: Intravenous General Anaesthetics Re
Page 45 and 46: Local Anaesthetics anaesthesia. Low
Page 47 and 48: Local Anaesthetics A/E: P/A: Dose:
Page 49 and 50: Preoperative Medication PREOPERATIV
Page 51 and 52: Preoperative Medication A/E: P/A: D
Page 53 and 54: SECTION - 2 ANALGESICS, ANTIPYRETIC
Page 55 and 56: Non-Steroidal Anti-Inflammatory Dru
Page 61 and 62: Opioid Analgesics P/A : Injection:
Page 63 and 64: Opioid Analgesics pain, 100 mg init
Page 65 and 66: Drugs in Rheumatoid Disorders P/A:
Page 67 and 68: Drugs in Rheumatoid Disorders IMPOR
Page 69 and 70: Medicines used for Gout Dose: Admin
Page 71 and 72: SECTION - 3 ANTI CONVULSANTS/ANTIEP
Page 73 and 74: Antiepileptics A/E: Cardiovascular
Page 75 and 76: Antiepileptics Ethosuximide I: Drug
Page 77 and 78: Antiepileptics hypotonia, coordinat
Page 79 and 80: Antiepileptics Topiramate I: Adjunc
Page 81 and 82: Antiepileptics Felbamate I: Unrespo
Page 83: SECTION - 4 ANTIINFECTIVE DRUGS ANT
Page 87 and 88: Cephalosporins Cephazolin I: Surgic
Page 89 and 90: Pencillins Cefdinir I: Pneumonia, c
Page 91 and 92: Aminoglycosides Gentamicin I: Urina
Page 93 and 94: Broad spectrum antibiotics I: Ricke
Page 95 and 96: Macrolides pertussis, endemic trach
Page 97 and 98: Macrolides photosensitivity; hepati
Page 99 and 100: Teicoplanin Cost: Tab 50 mg (10) Rs
Page 101 and 102: Fluoroquinolones A/E: Nausea, epiga
Page 103 and 104: Sulphonamides A/E: same as in cipro
Page 105 and 106: Antifungal drugs Sulphacetamide I:
Page 107 and 108: Antiviral drugs ANTI VIRAL DRUGS An
Page 109 and 110: Non selective antiviral drugs Dose:
Page 111 and 112: Antiretroviral drugs Dose: Oral, 30
Page 113 and 114: Antiretroviral drugs A/E : Rash inc
Page 115 and 116: Antimalarial drugs Artesunate I: Ml
Page 117 and 118: Antimalarial drugs Quinine I: Acts
Page 119 and 120: Antiamoebic and other protozoal dru
Page 121 and 122: Anthelmintics drugs Other drugs use
Page 123 and 124: Antifilarial drugs SCHISTOSOMICIDES
Page 125 and 126: SECTION - 5 ANTIMIGRAINE MEDICINES
Page 127 and 128: SECTION 6 ANTINEOPLASTIC DRUGS ALKY
Page 129 and 130: Antimetabolites Cost : Inj: 1 g via
Page 131 and 132: Antineoplastic Drugs Cost : 5-Fluor
Page 133 and 134: Cytotoxis Antibiotics P/A: Injectio
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Mitotic Inhibitors Epirubicin I: Ca
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Hormones and Hormonal antagonists P
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Targeted agents Progestins Medroxy
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Cytoprotective agents A/E: Infusion
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Dopaminergic agonist P/A: Dose: Bro
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MAO B Inhibitor MAO B Inhibitor Sel
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Central Anticholinergics daily (wit
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SECTION - 8 DRUGS ACTING ON BLOOD A
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Drug affecting Coagulation P/C: Can
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Haemolytic Anaemias HAEMOLYTIC ANAE
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Iron chelating drugs iron, aluminiu
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Acute Myelogenous Leukemia (All Tra
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Chronic Lymphocytic Leukemia dyspne
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Antiplatelet drugs Dose: 300 mg in
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Thrombolytic drugs Cost: lnj vial (
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Antifibrinolytics Tranexamic acid P
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Whole Blood/Components Storage and
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Plasma substitutes I: Short-term bl
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Plasma fractions for specific use H
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SECTION 10 CARDIOVASCULAR DRUGS DRU
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Drugs for Angina Dose : Oral : 10 m
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Drugs for Angina I : Angina pectori
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Lipid Lowering Drugs A/E: Reversibl
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Antihypertensive Drugs failure,neph
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Antihypertensive Drugs D/I: Arrhyth
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Antihypertensive Drugs Labetolol I:
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Antihypertensive Drugs Parenteral :
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Antihypertensive Drugs Mainly these
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Antihypertensive Drugs Alpha Methyl
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Antihypertensive Drugs Dose : In hy
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Drugs for Pulmonary Hypertension D/
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Drugs for Heart Failure Dopamine Do
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Anti Arrhythmic Drugs Dose: 250 - 5
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Anti Arrhythmic Drugs enzyme elevat
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Positive inotropic agents Dose : 2.
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Drugs for Superficial Mycosis P/A:
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Drugs for Deep Mycosis D/I: Increas
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Anti Bacterial for Topical Use P/C:
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Drugs used for Psoriasis Dithranol
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Drugs used for Warts P/C: Avoid use
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Drugs for other Dermatological Cond
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Drugs for other Dermatological Cond
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Drugs forLeprosy Rifampicin I: Lepr
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SECTION 12 DIAGNOSTIC AGENTS RADIOC
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Diagnostic agents A/E: Nausea, vomi
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Diagnostic agents reactions;hyperth
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SECTION 13 DISINFECTANTS AND ANTISE
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Disinfectants And Antiseptics ADMIN
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Disinfectants And Antiseptics Gluta
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Loop Diuretics P/A: Dose: Tablets 4
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Osmotic Diuretics D/I: Increases di
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SECTION 15 DRUGS USED IN DENTISTRY
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Drugs for Dentistry STEROIDS Triamc
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Drugs for ENT A/E: P/A: Candidiasis
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Drugs for ENT C/I : Hypersensitivit
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Ulcer Healing Drugs mecamylamine,ps
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Antispasmodics syndrome. Lansoprazo
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Antiemetics And Prokinetics radioth
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Anti Diarrhoeals gastroenteritis an
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Laxatives osteomalacia; complete de
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Drugs Used In Inflammatory Bowel Di
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Drugs Used In Gall Stones and Heamo
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SECTION 18 HORMONES AND OTHER ENDOC
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Adrenal Hormones And Synthetic Subs
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Adrenal Hormones And Synthetic Subs
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Antiandrogens Ointment 2 % w/w, 5 %
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Oestrogens And AntiOestrogens A/E:
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Progestins And Antiprogestins A/E :
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Insulin and Other Anidiabetic Drugs
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Insulin and Other Anidiabetic Drugs
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Thyroid and Anit Thyroid Drugs Cost
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Vitamin D Derivatives orally. Anxie
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Bisphosphonates Dose: Hypercalcemia
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Sera and immunoglobulins Hypersensi
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Vaccines Hepatitis B Immunoglobulin
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Vaccines Dose: Primary immunization
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Vaccines Child:1-15 years: IM, 0.5
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SECTION 20 IMMUNOSUPPRESSANT DRUGS
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Cytotoxic drugs A/E: Hypersensitivi
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Glucocorticoids I : C/I: P/C : A/E:
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Drug treatment of Urolithiasis I: I
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Benign prostatic hypertrophy Terazo
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Urinary Frequency and Enuresis Dose
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Drugs For Impotence A/E : Penile pa
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SECTION 22 MUSCLE RELAXANTS AND ANT
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Central Muscle Relaxants Botulinum
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Peripheral Muscle Relaxant D/I: Sam
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Anticholinesterases C/I: P/C: A/E:
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SECTION 23 OPHTHALMOLOGICAL PREPARA
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Corticosteroids used in Ophthalmolo
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Drug used for Glaucoma Antagonists
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Nutritional Disorders affecting the
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Drugs and Pregnancy Drugs to be avo
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Oxytocics The drip is started with
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Drugs for Induction of Labour PROST
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Drugs for Vaginitis 2. Oral : fluco
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Drugs for Dysfunctional Uterine Ble
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SECTION 25 PSYCHOTHERAPEUTIC DRUGS
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Antipsychotic Drugs Fluphenazine Hy
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Antipsychotic Drugs start initially
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Antipsychotic Drugs dose upto 200 m
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Antipsychotic Drugs Discontinue, if
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Antidepressants reduction of effect
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Antidepressants Doxepin I: Depressi
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Antidepressants Citalopram I, A/E a
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Antidepressants P/C: Renal or hepat
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Anxiolytics C/I: P/C: A/E: P/A: Dos
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Anxiolytics Adjunct in acute alcoho
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Drugs used in substance dependence
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SECTION 26 PAEDIATRIC DRUGS AND NUT
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Paediatric drugs 333
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Paediatric drugs Medication >50 % 1
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Paediatric drugs Dicyclomine Hydroc
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Paediatric drugs Terbutaline A/E: T
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Paediatric drugs Amiodarone: A/E :
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Paediatric drugs STATINS Atorvastat
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Paediatric drugs Fosphenytoin P/A:
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Paediatric Nutrition NUTRITION Reco
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Paediatric Nutrition Daily requirem
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Paediatric Nutrition 6. Vitamin K M
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Paediatric Nutrition Calcium Calciu
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Paediatric Nutrition Combination wi
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Drugs for Respiratory Diseases P/A:
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Drugs for Upper Respiratory tract i
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Drugs for Tuberculosis headache, at
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Drugs for Tuberculosis several mont
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Drugs for Asthma and COPD may produ
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Drugs for Tuberculosis Dose: Etophy
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Drugs for Tuberculosis P/A: Inhaler
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Drugs for Tuberculosis Drugs availa
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Cough Suppressants and Mucolytics I
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SECTION 28 SOLUTIONS CORRECTING WAT
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Oral rehydration Salts I : P/C: A/E
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Parental Solutions mmol/litre in 24
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Parental Solutions oedema or water
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Parental Solutions I: pre- and peri
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Total Parental Nutritions solution
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Intravenous access device used for
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Intravenous access device advanced
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Forms of Intravenous Therapy Effect
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Forms of Intravenous Therapy Fluid
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Vitamins and Minerals severe, iodiz
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Vitamins and Minerals be precipitat
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Vitamins and Minerals CHILD 75-125
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Vitamins and Minerals INFANT under
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PART II GUIDELINES FOR FIRST LINE M
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General Topics pulmonary emergencie
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General Topics If the patient is sh
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General Topics DECONTAMINATION The
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General Topics should be monitored.
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General Topics 13. Benzodiazepines
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General Topics FIRST AID 1. Reassur
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General Topics When to repeat ASV A
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General Topics stings should be war
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Paediatrics Dose: 1 packet of ORS d
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Paediatrics 5. fatigue and exhausti
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Paediatrics RECUSCITATION OF NEWBOR
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Paediatrics neurological status. If
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CARDIOLOGY Evaluation of chest pain
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Cardiology ST segment elevation can
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Cardiology Contraindications for be
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Cardiology Cardiac arrest and its m
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Cardiology the procedure so that mo
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Cardiology Approach to treatment de
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Cardiology Adrenergic inhibitors La
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Respiratory System case crystalline
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Respiratory System 3. Acute Iaryngi
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Respiratory System PLEURAL EFFUSION
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Alimentary System comatose. Cardiac
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Alimentary System such as aluminium
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Endocrinology ‣ Tachycardia ‣ H
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Endocrinology Thyroid crisis can be
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NEUROLOGY COMA Coma is one of the m
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Neurology anticonvulsant action of
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OBSTETRICS AND GYNECOLOGY HYPEREMES
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Obstetrics and Gynecology Transfer
Page 491 and 492:
Ophthalmology does not warrant any
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PART III A. LIST OF ESSENTIAL DRUGS
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Primary Care Hospitals 7. ANTIEPILE
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Secondary Care Hospitals 23.IMMUNOL
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Secondary Care Hospitals 44 TERBUTA
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Secondary Care Hospitals 90 GLYCERI
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Taluk Hospitals 140 INSULIN BOVINE,
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Taluk Hospitals 33 METRONIDAZOLE IN
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Taluk Hospitals 7. ANTIDOTES AND OT
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Taluk Hospitals 126 DIGOXIN TAB IP
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Taluk Hospitals 176 DEXTROSE INJ IP
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Tertiary Hospitals 28.VITAMINS & MI
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Tertiary Hospitals 46 AZITHROMYCIN
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Tertiary Hospitals 7. ANTIDOTES AND
Page 519 and 520:
Tertiary Hospitals 145 HEPARIN SODI
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Tertiary Hospitals 19. OPHTHALMIC D
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Tertiary Hospitals 249 HYDROGEN PER
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Tertiary Hospitals 303 FERROUS SULP
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Child Health 1. Progesterone only p
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Diarrhoea Control Programme end of
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National Immunization Schedule 5. N
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National TB Control Programme DOTS
Page 535 and 536:
National Filaria Control Programme
Page 537 and 538:
APPENDIX 1 PREGNANCY During pregnan
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Alcuronium Amitriptyline Amoxyillin
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Didanosine Diethylcarbamazine Doxyc
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Magnesium sulfate Medroxyprogestero
Page 545 and 546:
methaemoglobinaemia; fear of increa
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Table of medicines present in breas
Page 549 and 550:
Gentamicin Hydrochlorothiazide Insu
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dose leaving the normal interval be
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Benzathine penicillin Severe Neurot
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elimination such as clearance and h
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Heparin Hydralazine Hydrochlorothia
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APPENDIX : 6 LIST OF EMERGENCY MEDI
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1. ANAESTHETICS 1.1. General anesth
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4.2. Specific Antisnake Venom U Inj
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Clarithromycin* S,T Capsules 500 mg
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6.4.2.3 Protease inhibitors Indinav
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Etoposide* T Capsules 100mg Injecti
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12. CARDIOVASCULAR MEDICINES 12.1.
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Provide Iodine U Solution or Ointme
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17.2 Antiemetics Domperidone U Tabl
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Norethisterone U Tablets 5 mg 18.8
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Methyl Ergometrine U Tablets 0.125m
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Calcium salts U Tablets 250,500 mg
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Drugs Minimum Maximum Rifampicin 45
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54. Fixed dose combination of Analg
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APPENDIX 8 ADVERSE DRUG EVENT REPOR
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Amiloride .........................
Page 591 and 592:
Bromhexine ........................
Page 593 and 594:
Conjugated oestrogen ..............
Page 595 and 596:
Esmolol ...........................
Page 597 and 598:
Hydrochlorothiazide ...............
Page 599 and 600:
Loxapine ..........................
Page 601 and 602:
Nitrous Oxide .....................
Page 603 and 604:
Povidone iodine ...................
Page 605 and 606:
Sodium Thiosulphate ...............
Page 607:
Vaccines ..........................
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