Kerala State Drug Formulary.pdf

Iron chelating drugs
iron, aluminium overload in chronic haemodialysis
patients.
C/I : Renal impairment
P/C: Impaired renal function, children below 3 years,
increased susceptability to infection, pregnancy and
lactation.
A/E: Gastrointestinal disturbances, hepatic and renal
damage,anaphylaxis, arrhythmia, hypotension, blurring
of vision and local reactions at the site of injection.
P/A: Injection 500 mg / vial
Dose : 20 — 40 mg/kg/bw daily given as a, SC infusion overnight
or along with the blood transfusion.
This has to be repeated 4-5 times a week indefenitely
as long as transfusion therapy is needed.
D/I : Antipsychotic drugs administered concurrently may lead
to adverse interaction. Vit C enhances the urinary
elimination of iron and therefore acts synergistically.
Cost : Inj 500 mg / vial (5) Rs. 700.00/-
Deferiprone
It is an oral iron chelating drug
I : Iron chelation
P/C: Pregnancy and lactation.
A/E: Agranulocytosis, arthralgias, arthritis, drug· induced
lupus erythematosus, toxic overload of ron in the liver.
P/A : Tablets 250 mg, 500 mg.
Dose : 0.5 - 3 g daily (100 mg/kg bw) to be given 1 h before
food, in three divided doses.
Cost: Tablet 250 mg (50) Rs. 475.00
Heterozygous thalassemia (Thalassemia minor)
Essentials of therapy consist of strict avoidance of medicinal iron,
genetic counselling and iron chelation therapy when indicated.
DRUGS USED IN LEUKEMIA
Acute Lymphatic Leukemia
Remission induction therapy
Prednisolone, 40 mg/m 2 oral daily
Vincristine 1-1.5 mg / m 2 IV 7 days interval
Asparaginase 10,000 U/m 2 IV daily for 5 days
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