Kerala State Drug Formulary.pdf

Drugs used in diseases of kidney and urinary tract
Sildenafil
I: Erectile dysfunction.
C/I : Treatment with nitrates; conditions in which
vasodilation or sex activity is inadvisable; recent stroke
or myocardial infarction, blood pressure below 90/
50mmHg and hereditary degenerative retinal
disorders.
P/C : Cardiovascular disease; anatomical deformation of
penis; predisposition to prolonged erection (as in
sickle—cell anaemia, multiple myeloma ,leukaemia);
hepatic and renal impairment.
A/E : Dyspepsia; headache, flushing, dizziness, visual
disturbances increased intra-ocular pressure, nasal
congestion; rash and priapism reported; serious
cardiovascular events also reported.
P/A : Tablets, 25 mg, 50mg
Dose : ADULT: Oral, initial, 50mg (elderly 25mg) approximately
one hour before sexual activity, subsequent doses
adjusted according to response to 25-100mg as a single
dose as needed; max. one dose in 24 hours(max.
single dose 100mg).
D/I: hypotension when used with alpha blockers;
erythromycin increases its plasma concentration
25mg (4tablets) Rs 60- 80/-
Tadalafil
I : Erectile dysfunction.
C/I : As for sildenafil; also moderate heart failure,
uncontrolled arrhythmia, uncontrolled hypertension.
P/C : As for sildenafil.
A/E : As for sildenafil; also back pain, myalgia.
P/A : Tablets, 10mg, 20mg.
Dose : ADULT: Oral, initially 10mg at least 10 minutes before
sexual activity, subsequent doses adjusted according
to response to 20mg as a single dose ; Maximum 1
dose in 24 hours (but daily use not recommended).
Note: Effect may persist for longer than 24 hours.
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