Kerala State Drug Formulary.pdf

Antihypertensive Drugs
Labetolol
I: Systemic hypertension, hypertensive emergencies,
phaeochromo-cytoma.
C/ I: AV Block, bronchospasm, cardiogenic shock.
P/ C: CHF, diabetes mellitus, liver dysfunction, postural
hypotension.
A/E: Headache, hallucination, impotence.
P/A: Tablets. 50 mg, 100 mg, 200 mg.
Dose : 50 mg b.d., increased to 100 - 200 mg b.d.
D/I: Action of oral hypoglycemic agents increased, with
anaesthetic agents may cause myocardial depression.
Cost: Tab 50 mg (10) Rs. 15.00 - 16.00
Carvedilol
Carvedilol is a beta blocker with additional vasodilatory
action.Therefore it lowers peripheral resistance also.
I: Hypertension and in patients with mild CHF
C/I: P/C: Same as propranolol
A/E: postural hypotension, headache, fatigue, flu-like
symptoms, rarely angina, heart block, allergic skin
rashes, nasorespiratory allergy,mental depression,
insomnia, paresthesia, hepatic dysfunction,leucopenia,
thrombocytopenia.
P/A: Tablets 12.5 mg, 25 mg
Dose: Start with 6.25 mg daily orally and increased to 25-50
mg depending upon clinical response. Lower dose in
elderly patients(25 mg)
Cost: Tab 12.5 mg (10) Rs. 95.00-100.00
Other Beta blockers currently used are NEBIVOLOL, CELIPROLOL
and ACEBUTOLOL
Calcium channel blockers
Verapamil
This is a calcium channel blocker drug with antihypertensive,antianginal
and antiarrhythmic properties.
I: Supraventricular tachycardias, systemic hypertension,
coronary artery disease with effort angina and
vasospastic angina,hypertrophic cardiomyopathy,
migraine.
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