Kerala State Drug Formulary.pdf

General advice to Prescribers
necessary to prevent ADRs. The genetic make-up of the individual patient
may also predispose to ADRs.
ADR Reporting
• Report adverse experiences with medications
• Report serious adverse events. An event is serious when the patient
outcome is
Death
Life threatening (real risk of dying)
Hospitalisation(initial or prolonged)
Disability (significant persistent or permanent)
Congenital anomaly
Required intervention to prevent permanent impairment or damage
Report even if
• you are not certain the product caused adverse event
• you don’t have all the details
Who can report
• Any health care professional
(Doctors including Dentists,Nurses and Pharmacists)
Where to report
• Nearest ADR monitoring centres
• Peripheral Pharmacovigilance centres (24)
• Regional Pharmacovigilance centres(5)
• Directly to www.cdsco.nic.in
Drug Interactions.
Interactions may occur between drugs which compete for the same
receptor or act on the same physiological system. They may also occur
indirectly when a drug-induced disease or a change in fluid or electrolyte
balance alters the response to another drug.Interactions may occur when
one drug alters the absorption, distribution or elimination of another drug,
such that the amount which reaches the site of action is increased or
decreased.Drug-drug interactions are some of the commonest causes of
adverse effects.When two drugs are administered to a patient, they may
either act independently of each other, or interact with each other. Interaction
may increase or decrease the effects of the drugs concerned and may cause
unexpected toxicity. As newer and more potent drugs become available, the
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