Kerala State Drug Formulary.pdf

Antineoplastic Drugs
Vincristine
I : Acute leukaemia, lymphoma, neuroblastoma, Wilm’s
tumour.
C/I: Intrathecal administration, demyelinating Charcoat -
Marie disease, pregnancy, tooth syndrome.
P/C : Infection, neuromuscular disease, leucopenia,
pulmonary diseases, leukaemia, radiation therapy,
extravasation, concomitant neurotoxic drugs, eye
contact, concurrent vaccination.
A/E: Local reaction if extravasation occurs, constipation,
paralytic ileus, jaw pain, bone marrow depression,
peripheral neuropathy, syndrome of inappropriate
antidiuretic hormone (SIADH), breath-lessness, hyper
or hypotension.
P/A : Injection 1 mg, 5 mg ampoules.
Dose : 1.5 - 2 mg/m 2 IV weekly
D/I : Decreased plasma digoxin level. Hepatic clearance of
vincristine is reduced if L-asparaginase is administered
first. So Vincristine should be given 12-24 hrs before L-
asparaginase, acute pulmonary reaction may occur with
mitomycin,reduced plasma phenytoin levels.
Cost: Inj. (1 mg) vial –Rs 48.00 – Rs. 63.00
MISCELLANEOUS AGENTS
L- Asparaginase:
I: Acute Lymphocytic Leukemia for induction therapy.
C/I: Pancreatitis, serious allergic reactions
A/E: Myelosuppression, Nausea,Vomiting, Anaphylaxis
20 –30%
P/A: 10,000 KU/vial injection.
Dose: 50-200 KU/kg IV daily for 2 to 4 weeks.
Cost: Inj. (5000 IU) vial – Rs. 970.00
Cisplatin
I: Testis, ovary, endometrial, cervical, bladder, head and
neck, gastro intestinal and lung carcinomas; soft tissue
and bone sarcomas, Non hodgkin’s lymphoma.
P/C: Do not administer if serum creatinine level
> 1.5 mg/dL
A/E: Same as above drug, including renal tubular damage,
ototoxicity.
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